Endocrinology and Hormones
Endocrinology and Hormones
The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more
Targets for Endocrinology and Hormones
- 5-alpha Reductase(8)
- Smoothened Receptors(3)
- Androgen Receptor(137)
- Aromatase(13)
- CRTH2(2)
- Estrogen/progestogen Receptor(147)
- GnRH(26)
- Opioid Receptor(175)
- RAAS(8)
- Thyroid hormone Receptor(59)
- TRH(2)
- ROR/RAR/RXR(94)
- FXR & LXR(69)
- Glucocorticoids & Mineralocorticoids(49)
- GPR(1)
Products for Endocrinology and Hormones
- Cat.No. Product Name Information
- GC49123 Somatorelin (1-44) amide (human) (trifluoroacetate salt) A synthetic GHRH peptide
- GC44914 Somatostatin-14 (acetate) Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin.
- GC49574 Somatostatin-28 (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A cyclic neuropeptide hormone
- GC52390 Spexin 1 (human, mouse, rat, bovine) (acetate) An endogenous peptide and agonist of GAL2 and GAL3
- GC63200 Spiradoline
- GC12516 Spironolactone Competitive mineralocorticoid (aldosterone) receptor antagonist
- GC45567 SR 1903
- GC13680 SR-9243 inverse agonist of LXR
- GC14638 SR9238 inverse agonist of the two LXR isoforms, LXRα and LXRβ
- GC37687 Stanolone benzoate
- GC37691 Stigmasterol glucoside Stigmasterol glucoside is a sterol isolated from P.
- GC10596 T0901317 Liver X receptor agonist,potent and selective
- GC34822 T3-ATA S-isomer T3-ATA S-isomer is the S-isomer of T3-ATA, which is the active form of the thyroid hormone.
- GC34824 T4-ATA S-isomer
- GC16649 TAK-700 (Orteronel) A non-steroidal inhibitor of the 17,20-lyase activity of CYP17A1
- GC17063 Talarozole
- GC17983 Taltirelin novel orally active TRH analogue
- GC37732 Taltirelin acetate Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
- GC13984 Tamibarotene A selective RARα agonist
- GC11669 Tamoxifen Citrate Antiestrogen drug
- GC40301 Tamoxifen N-oxide Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects.
-
GC50558
TAN 452
Potent and selective peripherally acting δ opioid antagonist; antianalgesic.
- GC16847 Tanaproget
- GC44999 Tauro-α-muricholic Acid (sodium salt) Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid.
- GC49011 Tauro-α-muricholic Acid-d4 (sodium salt) An internal standard for the quantification of tauro-α-muricholic acid
- GC45000 Tauro-β-muricholic Acid (sodium salt) Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM.
- GC49012 Tauro-β-muricholic Acid-d4 (sodium salt) An internal standard for the quantification of tauro-β-muricholic acid
- GC44998 Tauro-Obeticholic Acid Tauro-obeticholic acid is a taurine-conjugated form of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid.
- GC15459 Tazarotene Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor
- GC45001 Tazarotenic Acid Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM.
- GC10567 TCPOBOP constitutive androstane receptor (CAR) agonist
- GC49055 Tebuconazole-d9 An internal standard for the quantification of tebuconazole
- GC15023 Telmisattan Telmisattan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
- GC46230 Terrelumamide A A peptide fungal metabolite
-
GC45935
Testosterone
An Analytical Reference Material
- GC39451 Testosterone (propionate)
- GC63935 Testosterone buciclate
- GC63217 Testosterone undecanoate
- GC40341 Tetrahydro-11-deoxy Cortisol Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol.
- GC12445 TFM-4AS-1 androgen receptor modulator
- GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan
- GC48358 Thymulin (acetate hydrate) A peptide hormone
- GC10413 Thyroid Hormone Receptor Antagonist (1-850) Thyroid hormone receptor antagonist
- GC31328 Thyroxine sulfate (T4 Sulfate) Thyroxine sulfate (T4 Sulfate) is a thyroid hormone metabolite.
- GC41153 Tibolone Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.
- GC15001 Tiratricol thyroid hormone analogue
- GC13362 TOK-001 TOK-001 (TOK-001) is a multifunctional antiandrogen and CYP17 inhibitor (IC50=47 nM) in castration resistant prostate cancer (CRPC).
- GC11544 Toremifene
- GC13835 Toremifene Citrate Oral selective estrogen receptor modulator (SERM)
- GC31402 TR antagonist 1 TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
- GC65255 Trestolone
- GC18147 Tretinoin (Aberela) Tretinoin (Aberela) is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Tretinoin (Aberela) is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Tretinoin (Aberela) bind to PPARβ/δ with Kd of 17 nM. Tretinoin (Aberela) acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
-
GP10112
TRH Precursor Peptide
Thyrotropin Releasing Hormone Precursor Peptide
- GC31935 Trifarotene (CD5789) Trifarotene (CD5789) (CD5789) is a potent and selective RARγ agonist.
- GC10702 Trimebutine Antimuscarinic
- GC37829 Trimebutine maleate Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.
- GN10268 Triptophenolide
- GC49475 Triptorelin (trifluoroacetate salt) A synthetic GNRH peptide agonist
- GC32772 Triptorelin ([DTrp6]-LH-RH) A synthetic GNRH peptide agonist
- GC49389 Tritylolmesartan Medoxomil An intermediate in the synthesis of olmesartan medoxomil
- GC19363 Tropifexor Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
- GC14273 TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid) is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
- GC49329 Turkesterone (hydrate) A phytoecdysteroid with diverse biological activities
- GC30816 Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
- GC15512 U-54494A hydrochloride κ-opioid agonist and NMDA antagonist
- GC61586 UFP-101 TFA UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24.
- GC11677 Ulipristal acetate Novel selective progesterone receptor modulator (SPRM)
- GC48219 Ulipristal Acetate-d6 An internal standard for the quantification of ulipristal acetate
- GC18231 Urocortin II (human) (trifluoroacetate salt) Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.
- GC45588 Urocortin II (mouse) (trifluoroacetate salt)
- GC45589 Urocortin III (human) (trifluoroacetate salt)
- GC45590 Urocortin III (mouse) (free acid) (trifluoroacetate salt)
- GC45591 Urocortin III (mouse) (trifluoroacetate salt)
- GC32908 UT-155 UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD.
- GC62124 UT-34 UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively.
- GC13199 UVI 3003 RXR antagonist
- GC52242 V-125 An RXR agonist
- GC31126 Valorphin Valorphin is an endogenous hemoglobin β-chain (33-39) fragment with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM; Valorphin also shows anti-tumor activity.
- GC30994 Vanilpyruvic acid (Vanylpyruvic acid) Vanilpyruvic acid (Vanylpyruvic acid) is a catecholamine metabolite and precursor to vanillactic acid.
- GC45139 Vapreotide (trifluoroacetate salt) Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay).
- GC37913 Vitamin A An intermediate in retinol metabolism 325,000 IU/g
-
GC70128
VPC-14228
VPC-14228 is an effective androgen receptor DNA binding domain (AR-DBD) inhibitor that can interfere with the interaction between AR and androgen response elements, effectively blocking AR transcriptional activity. VPC-14228 can be used for research on prostate cancer.
- GC62329 VPC-14449 VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC50 of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer.
- GC13309 WAY 200070 ERβ receptor agonist
- GC52180 WAY-169916 WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity.
- GC34862 WYC-209 WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19?μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity.
- GC10789 XCT790 ERRα agonist
- GC32459 XL041 (BMS-852927) XL041 (BMS-852927) (BMS-852927) is an LXRβ-selective agonist.
- GC10760 XL335 XL335 (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM.
- GC10346 Y 134 estrogen receptor modulator
-
GC70155
YCT529
YCT529 is an effective, selective, and orally active RAR-α inhibitor.
- GC31442 YK11 A partial agonist of the androgen receptor
- GC40293 Z3-Dodecenyl E2-butenoate Z3-Dodecenyl E2-butenoate is a female sex pheromone produced by the sweet potato weevil, C.
- GC10684 Zearalanone estrogen receptor agonist
- GC12767 Zearalenone Mycotoxin produced by several species of Fusarium fungi.
- GC16742 ZK 164015 estrogen receptor silent antagonist
- GC31006 ZT 52656A hydrochloride ZT 52656A is a selective kappa opioid agonist, used for the prevention or alleviation of pain in the eye.
- GC52414 [Ala17]-MCH (trifluoroacetate salt) An MCH-derived peptide and MCH receptor agonist
- GC11848 [D-Ala2]-Deltorphin II [D-Ala2]-Deltorphin II is a selective peptide agonist for the δ opioid receptor.
- GC33081 [D-Ala2]leucine-enkephalin [D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.