Others

YL-365 is a potent GPR34 antagonist with an IC 50 value of 17nM.

TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity.

UNC3474 is a small molecule ligand, binding with 53BP1.

Nurr1 agonist 7 (compound 110) is a Nurr1 agonist with an EC50 value of 0.12 μM.

VJDT is a TREM1 small molecule inhibitor that effectively blocks TREM1 signaling.

ACBI3 is a selective pan-KRAS degrader (PROTAC), composed of a target protein ligand (pan-KRAS degrader 1, used to bind KRAS protein), an E3 ligase ligand (E3 ligase Ligand 43, used to recruit the VHL E3 ubiquitin ligase complex), and a linker (1-Bromo-4-(ethynyloxy)butane, used to optimize spatial conformation).

UNC2383 is an oligonucleotide enhancing compound that can enhance effects of antisense oligonucleotides (ASOs), and splice switching oligonucleotides (SSOs).

malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity.

(R)-Birabresib is the isomer of Birabresib , and can be used as an experimental control.

KMI169 is a potent and selective bi-substrate inhibitor targeting the SAM and substrate binding pockets of KMT9.

DHC-156 is a selective Bracury small molecule downmodulator.

SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)–associated factor 29 (SGF29)-Tudor domain.

cis-KIN-8194 is the cis-isomer of KIN-8194.

Triptolide palmitate is the derivative of Triptolide.

ORIC-944 is a selective, orally active, allosteric inhibitor targeting the EED subunit of polycomb repressive complex 2 (PRC2).

ORIC-944 TFA is the TFA salt form of ORIC.

BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine.

MY-1B is a covalent inhibitor of the RNA Metltransferase NSUN2 (IC50: 1.3 μM).

Nesosteine is a bronchitis inhibitor that improves the rheology and production of airway bronchial mucus in rabbits.

3-sucCA (3-Succinylated cholic acid) is a microbial derived bile acid.

ALKBH1-IN-2 (Compound 16) is a derivative of ALKBH1-IN-1.

VCPIP1-IN-1 (Compound 001) is a VCPIP1 inhibitor, with an IC50 of 0.41 μM.

7-(2-Aminoetl)camptothecin TFA (7CPT TFA) is the TFA salt form of Camptothecin derivative 7-(2-Aminoetl)camptothecin.

HN252 is a potent PPM1B inhibitor (Ki= 0.52 µM).