Stem Cell
- CK1(7)
- EZH2(15)
- GSK-3(56)
- HSC(8)
- iPSC(11)
- Hedgehog(41)
- Notch(42)
- Smoothened(38)
- Wnt/β-catenin(128)
- Hippo Signaling(5)
- Cancer stem cell(23)
- MST1/2(1)
- ESC(1)
- Casein Kinase(33)
- Oct3/4(5)
- Porcupine(6)
- YAP(22)
Products for Stem Cell
- Cat.No. Product Name Information
- GC36073 Foxy-5 Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.
- GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α).
- GC17457 FRATide GSK-3 inhibitor
- GC41534 FzM1 Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.
- GC50624 FzM1.8 Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness
- GC18595 G244-LM An inhibitor of Wnt signaling
- GC65116 GA-017 GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.
- GC43725 Gallocyanine Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction.
- GC43729 Ganglioside GD3 Mixture (sodium salt) Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases.
- GC43734 Ganglioside GQ1b Mixture (sodium salt) Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit.
- GC16789 GANT 58 An inhibitor of Gli transcription
- GC10359 GANT61 GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM.
- GC10493 GDC-0449 (Vismodegib)
- GC33304 Gigantol Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.
- GC31717 Ginkgetin A biflavonoid with diverse biological activities
- GC32877 GNF-6231 GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
- GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells).
- GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis
- GC14640 GSA 10 Smoothened (Smo) receptor agonist
- GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3.
- GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.
- GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM.
- GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research.
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GC15783
GSK126
A selective EZH2 inhibitor
- GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes.
- GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor
- GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β
- GC11414 GSK503 EZH2 inhibitor
- GC14896 Halcinonide Anti-inflammatory agent
- GC43809 Hedgehog Antagonist VIII Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened.
- GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells.
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GC30767
Heparan Sulfate
Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix.
- GC49027 Hexamethylene bisacetamide Hexamethylene bisacetamide is a tumor cell-differentiating agent.
- GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM.
- GC12951 HhAntag A hedgehog pathway inhibitor
- GC16963 HLY78 positive modulator of the Wnt/β-catenin pathway
- GC11045 HPI 1 HPI 1 is a potent GLI antagonist with an IC50 value of 1.1 μM. HPI 1 shows anti-proliferative activity. HPI 1 decreases the GLI1 mRNA expression. HPI 1 inhibits colony formation in a dose-dependent manner.
- GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor
- GC43873 Hydrocortisone 21-hemisuccinate (sodium salt) Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol.
- GC61410 I3MT-3 I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM).
- GC14503 IC261 CK1 inhibitor
- GC16893 ICG 001 An inhibitor of β-catenin/CBP interactions
- GC16640 iCRT 14 CRT inhibitor
- GC19198 iCRT3 iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
- GC15123 IDE 1 activate the TGF-β signaling pathway
- GC10854 IDE 2 inducer of definitive endoderm formation
- GC50203 IHR-Cy3 Potent fluorescent Smo antagonist
- GC16617 IM-12 GSK-3β inhibitor, potent
- GC12741 IMR-1 Notch pathway inhibitor
- GC36304 IMR-1A IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A.
- GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
- GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively.
- GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β.
- GC10910 IQ 1 IQ 1 is a Wnt/β-catenin/CBP signalling sustainer.
- GC10472 ISX 9 Neurogenic agent
- GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole
- GC16013 IWP 4 Potent inhibitor of Wnt/β-catenin signaling
- GC16454 IWP-2 IWP-2 is a inhibitor of the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 is also an ATP-competitive inhibitor of CK1δ, with an IC50 value of 40 nM.
- GC14546 IWP-2-V2 Wnt production inhibitor
- GC17071 IWP-3 inhibitor of Wnt production
- GC17708 IWP-L6 Porcupine inhibitor,highy potent
- GC34628 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
- GC10950 IWR-1-endo IWR-1-endo is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
- GC36361 Jagged-1 (188-204) TFA A fragment of the Jagged-1 (JAG-1) protein
- GC36362 Jagged-1 188-204 Jagged-1 188-204 is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells.
- GC11111 Jervine Hedgehog signaling Inhibitor
- GC34635 JI051 JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.
- GC15256 JK 184 Hh signaling inhibitor
- GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH.
- GC12869 JW 55 A TNKS1/2 inhibitor
- GC10138 JW 67 inhibitor of canonical Wnt pathway signaling
- GC13978 JW 74 inhibitor of the catalytic PARP domain of TNKS1/2
- GC62132 K-975 K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma.
- GC15057 Kartogenin Promote differentiation of multipotent MSCs into chondrocytes
- GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor
- GC13582 KHS 101 hydrochloride neuronal differentiation inducer
- GC14572 KY 02111 Induces stem cell differentiation
- GC46015 KY 05009 A TNIK inhibitor
- GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor.
- GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor.
- GC32923 KY1220 KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.
- GC19216 KYA1797K A potent and selective Wnt/β-catenin inhibitor
- GC47538 L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression.
- GC36483 L-Quebrachitol L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.
- GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3)
- GC61527 Lats-IN-1 Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases.
- GC13655 LDE225 (NVP-LDE225,Erismodegib) LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
- GC14169 LDE225 Diphosphate A Smo antagonist
- GC32954 LEQ506 (NVP-LEQ506) LEQ506 (NVP-LEQ506) is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
- GC32763 LF3 LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM.
- GC12392 LGK-974 PORCN inhibitor,potent and specific
- GC17466 LH846 Casein kinases inhibitor
- GC47570 Lipoxygenin An inhibitor of 5-LO
- GC44080 LLP-3 Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins.
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GC34650
Longdaysin
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of? 5.6 ?M, 8.8 ?M, 29 ?M, and 52 ?M, respectively.
- GC12191 LY-411575 A γ-secretase inhibitor
- GC15683 LY2940680 LY2940680 (LY2940680) is an antagonist of the smoothened receptor.
- GC12653 LY3039478 A Notch inhibitor
- GC13041 M 25 Smoothened (Smo) receptor antagonist
- GC25603 M2912 M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.