Wnt/β-catenin
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
Products for Wnt/β-catenin
- Cat.No. Product Name Information
- GC62432 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.
- GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
- GC66371 (E)-Ferulic acid-d3 (E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
- GC45354 4β-Hydroxywithanolide E A withanolide with anti-inflammatory and anticancer activities
- GC42669 ABC99 An inhibitor of NOTUM
- GC31663 Adavivint (SM04690) Adavivint (SM04690) (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
- GC50323 AMBMP hydrochloride AMBMP hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50of 700 nM.
- GC65165 Carboxylesterase-IN-2 Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease.
- GC65167 Carboxylesterase-IN-3 Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease.
- GC17840 Cardiogenol C hydrochloride Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes
- GC17782 Cardionogen 1 Wnt signaling modulator
- GC10253 CCT 031374 hydrobromide inhibits TCF-dependent transcription, blocks BIO-induced β-catenin stabilization
- GC17606 CCT251545 Orally bioavailable and potent WNT signaling inhibitor
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GC16702
CHIR-99021 (CT99021)
A selective GSK3 inhibitor
- GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy.
- GC64816 Coronaridine Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression.
- GC35873 DK419 DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.
- GC32914 EMT inhibitor-1 EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
- GC19144 ETC-159 ETC-159 is a potent, orally available PORCN inhibitor.
- GC14299 exo-IWR 1 Negative control for endo-IWR 1 (Wnt signaling inhibitor)
- GC12134 FH535 An inhibitor of β-catenin signaling
- GC62214 FIDAS-3 FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities.
- GC36073 Foxy-5 Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.
- GC41534 FzM1 Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.
- GC50624 FzM1.8 Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness
- GC18595 G244-LM An inhibitor of Wnt signaling
- GC43725 Gallocyanine Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction.
- GC33304 Gigantol Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.
- GC31717 Ginkgetin A biflavonoid with diverse biological activities
- GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β
- GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells.
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GC30767
Heparan Sulfate
Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix.
- GC16963 HLY78 positive modulator of the Wnt/β-catenin pathway
- GC16893 ICG 001 An inhibitor of β-catenin/CBP interactions
- GC16640 iCRT 14 CRT inhibitor
- GC19198 iCRT3 iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
- GC15123 IDE 1 activate the TGF-β signaling pathway
- GC10854 IDE 2 inducer of definitive endoderm formation
- GC10910 IQ 1 IQ 1 is a Wnt/β-catenin/CBP signalling sustainer.
- GC10472 ISX 9 Neurogenic agent
- GC16013 IWP 4 Potent inhibitor of Wnt/β-catenin signaling
- GC16454 IWP-2 IWP-2 is a inhibitor of the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 is also an ATP-competitive inhibitor of CK1δ, with an IC50 value of 40 nM.
- GC14546 IWP-2-V2 Wnt production inhibitor
- GC17071 IWP-3 inhibitor of Wnt production
- GC17708 IWP-L6 Porcupine inhibitor,highy potent
- GC34628 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
- GC10950 IWR-1-endo IWR-1-endo is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
- GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH.
- GC12869 JW 55 A TNKS1/2 inhibitor
- GC10138 JW 67 inhibitor of canonical Wnt pathway signaling
- GC13978 JW 74 inhibitor of the catalytic PARP domain of TNKS1/2
- GC15057 Kartogenin Promote differentiation of multipotent MSCs into chondrocytes
- GC13582 KHS 101 hydrochloride neuronal differentiation inducer
- GC46015 KY 05009 A TNIK inhibitor
- GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor.
- GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor.
- GC32923 KY1220 KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.
- GC19216 KYA1797K A potent and selective Wnt/β-catenin inhibitor
- GC36483 L-Quebrachitol L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.
- GC32763 LF3 LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM.
- GC12392 LGK-974 PORCN inhibitor,potent and specific
- GC47570 Lipoxygenin An inhibitor of 5-LO
- GC25603 M2912 M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.
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GC31794
Methyl vanillate
Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator.
- GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.
- GC19260 NCB-0846 NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM.
- GC64837 Nefopam D3 hydrochloride
- GC11775 Nefopam HCl Nefopam HCl (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain.
- GC38522 Neurodazine Small molecule inducer of neuronal differentiation
- GC11454 Neurodazine Induces neurogenesis of non-pluripotent C2C12 myoblasts
- GC50489 NLS-StAx-h Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions
- GC67737 NLS-StAx-h TFA
- GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM.
- GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation.
- GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
- GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM.
- GC44467 NSC 668036 NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain).
- GC11115 Pamidronate Pamidronate is a drug used to treat a broad spectrum of bone absorption diseases.
- GC18291 PKF118-310 PKF118-310 (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity.
- GC16711 PNU 74654 Wnt signaling pathway inhibitor
- GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite.
- GC32698 Pyrvinium pamoate (Pyrvinium embonate) Pyrvinium pamoate (Pyrvinium embonate) is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling.
- GC17251 QS 11 ARFGAP1 inhibitor,Wnt/beta-catenin pathway modulator
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GC69802
RA-V
RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75 and 93 ng/mL respectively. RA-V can be used for research on cancer-related signaling pathways.
- GC14882 Salinomycin A selective cancer stem cell inhibitor
- GC18107 Salinomycin sodium salt A selective cancer stem cell inhibitor
- GC16320 Shz 1 induces phenotypic differentiation
- GC16701 SKI II Sphingosine kinase(SK) inhibitor
- GC16382 SKL2001 An activator of Wnt/β-catenin signaling
- GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor
- GC11548 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
- GC13301 TCS 2210 Inducer of neuronal differentiation in mesenchymal stem cells (MSCs)
- GC39159 Tegatrabetan Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1).
- GC62394 Teplinovivint Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor.
- GC14037 Triptonide A diterpenoid with diverse biological activities
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GC50077
WAY 316606 hydrochloride
Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
- GC15753 WAY-262611 β-Catenin agonist
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GC70143
WIC1
WIC1 is an effective Wnt inhibitor that can be used in cancer research.
- GC11674 WIKI4 A potent TNKS1/2 inhibitor
- GC12133 Windorphen Wnt inhibitor