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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC62630 TAS-117 hydrochloride TAS-117 hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 hydrochloride induces apoptosis and autophagy. TAS-117 hydrochloride Chemical Structure
  3. GC62342 TASP0415914 TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 Chemical Structure
  4. GC12181 TBB An inhibitor of CK2 TBB Chemical Structure
  5. GC14181 TBCA

    CK2 inhibitor

     TBCA Chemical Structure
  6. GC50332 TC KHNS 11 Potent and selective PI 3-kinase δ inhibitor; orally bioavailable TC KHNS 11 Chemical Structure
  7. GC13576 TC-G 24

    GSK-3β inhibitor

     TC-G 24 Chemical Structure
  8. GC10440 TCS 183 competitive inhibitor of GSK-3β (Ser9) phosphorylation TCS 183 Chemical Structure
  9. GC11515 TCS 184 Scrambled control peptide for use with TCS 183 TCS 184 Chemical Structure
  10. GC11627 TCS 2002 TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS 2002 Chemical Structure
  11. GC16584 TCS 21311 A JAK3 inhibitor TCS 21311 Chemical Structure
  12. GC62191 TD52 TD52, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity. TD52 Chemical Structure
  13. GC64936 TD52 dihydrochloride TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity. TD52 dihydrochloride Chemical Structure
  14. GC14840 TDZD-8 GSK-3β inhibitor TDZD-8 Chemical Structure
  15. GC12573 Temsirolimus

    A MTOR inhibitor

     Temsirolimus Chemical Structure
  16. GC32828 Tenalisib (RP6530) Tenalisib (RP6530) (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively. Tenalisib (RP6530) Chemical Structure
  17. GC15151 TG100-115 PI3Kγ/PI3Kδ inhibitor TG100-115 Chemical Structure
  18. GC16231 TG100713 pan-PI3K inhibitor TG100713 Chemical Structure
  19. GC41573 Theaflavin 3,3'-digallate

    Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities.

     Theaflavin 3,3'-digallate Chemical Structure
  20. GC14465 Tideglusib non-ATP-competitive GSK-3β inhibitor Tideglusib Chemical Structure
  21. GC61336 TMBIM6 antagonist-1 TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+. TMBIM6 antagonist-1 Chemical Structure
  22. GC10131 Torin 1

    MTOR inhibitor,potent and selective

     Torin 1 Chemical Structure
  23. GC13858 Torin 2 MTOR inhibitor,highly potent and selective Torin 2 Chemical Structure
  24. GC15392 Triciribine Akt inhibitor,highly selective Triciribine Chemical Structure
  25. GC10649 TTP 22 A CK2 inhibitor TTP 22 Chemical Structure
  26. GC17868 TWS119

    GSK-3β inhibitor

     TWS119 Chemical Structure
  27. GC18164 UCB9608

    PI4KIIIβ inhibitor

     UCB9608 Chemical Structure
  28. GC10857 UCN-01 inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases UCN-01 Chemical Structure
  29. GC65454 UCT943 UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 Chemical Structure
  30. GC19355 Umbralisib TGR-1202 is a PI3Kδ inhibitor, with IC50 and EC50 of 22.2 nM and 24.3 nM, respectively. Umbralisib Chemical Structure
  31. GC37854 Umbralisib hydrochloride Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach. Umbralisib hydrochloride Chemical Structure
  32. GC37855 Umbralisib R-enantiomer Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. Umbralisib R-enantiomer Chemical Structure
  33. GC37859 Uprosertib hydrochloride Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. Uprosertib hydrochloride Chemical Structure
  34. GC38679 Urolithin B A metabolite of ellagic acid Urolithin B Chemical Structure
  35. GC64231 Vevorisertib trihydrochloride Vevorisertib (ARQ 751) trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors. Vevorisertib trihydrochloride potently inhibit phosphorylation of AKT. Vevorisertib trihydrochloride has Kd values of 1.2 nM and 8.6 nM for AKT1 and AKT1-E17K, respectively. Vevorisertib trihydrochloride has IC50 values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively. Vevorisertib trihydrochloride can be used for the research of cancer. Vevorisertib trihydrochloride Chemical Structure
  36. GC41527 Viridiol Viridiol is a fungal steroid that demonstrates phytotoxic activity. Viridiol Chemical Structure
  37. GC37922 Voxtalisib A dual inhibitor of PI3K and mTORC Voxtalisib Chemical Structure
  38. GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 Chemical Structure
  39. GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide Chemical Structure
  40. GC26044 VPS34 inhibitor 1 (Compound 19) VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. VPS34 inhibitor 1 (Compound 19) Chemical Structure
  41. GC32932 Vps34-IN-2 Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively. Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC50 of 3.1 μM), HCoV-229E (IC50 of 0.7 μM) and HCoV-OC43. Vps34-IN-2 Chemical Structure
  42. GC10436 VPS34-IN1 Vps34 inhibitor VPS34-IN1 Chemical Structure
  43. GC17771 VS-5584 (SB2343) A selective PI3K/mTOR kinase inhibitor VS-5584 (SB2343) Chemical Structure
  44. GC48256 VS-5584 analog VS-5584 analog is a dimethyl analog of VS-5584 which is an potent and selective mTOR/PI3K dual inhibitor with pyrido [2,3-d] pyrimidine structure. VS-5584 analog Chemical Structure
  45. GC70138 Vulolisib

    Vulolisib is an effective and orally active phosphoinositide 3-kinase (PI3K) inhibitor with IC50 values of 0.2 nM, 168 nM, 90 nM, and 49 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively. It has anti-proliferative activity against cancer cells and also exhibits anti-tumor activity.

     Vulolisib Chemical Structure
  46. GC33325 VX-984 (M9831) VX-984 (M9831) (M9831) is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 (M9831) efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 (M9831) can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 (M9831) Chemical Structure
  47. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. WAY-119064 Chemical Structure
  48. GC10583 WAY-600 MTOR inhibitor WAY-600 Chemical Structure
  49. GC12338 Wortmannin Wortmannin is a highly potent direct inhibitor of PI3-kinase specificity originally derived from fungi (1,2). Wortmannin Chemical Structure
  50. GC45160 Wortmannin-Rapamycin Conjugate Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin-Rapamycin Conjugate Chemical Structure
  51. GC14675 WYE-125132 (WYE-132) WYE-125132 (WYE-132) (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-125132 (WYE-132) (WYE-125132) inhibits mTORC1 and mTORC2. WYE-125132 (WYE-132) Chemical Structure
  52. GC13321 WYE-687 MTOR inhibitor,ATP-competitive and selective WYE-687 Chemical Structure
  53. GC38473 WYE-687 dihydrochloride WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively. WYE-687 dihydrochloride Chemical Structure
  54. GC16549 WZ4003 NUAK1/2 inhibitor, potent and selective WZ4003 Chemical Structure
  55. GC61382 Xanthoangelol Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol Chemical Structure
  56. GC12709 XL147 XL147 (XL147 analogue) is a representative and selective PI3Kα inhibitor extracted from patent WO2012006552A1, Compound 147 in Table 1. XL147 Chemical Structure
  57. GC16481 XL388 An mTOR inhibitor XL388 Chemical Structure
  58. GC12336 XL765 PI3K/mTOR inhibitor XL765 Chemical Structure
  59. GC64992 YH-306 YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization. YH-306 Chemical Structure
  60. GC18208 YLF-466D YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis. YLF-466D Chemical Structure
  61. GC10982 YM201636 PIKfyve inhibitor,potent and selective YM201636 Chemical Structure
  62. GC37954 YS-49 YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 Chemical Structure
  63. GC37955 YS-49 monohydrate YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 monohydrate Chemical Structure
  64. GC19390 YU238259 YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research. YU238259 Chemical Structure
  65. GC10195 Z-Guggulsterone

    Z-Guggulsterone suppresses angiogenesis in vitro and in vivo with IC50 values of 1740, 1000, 220 and > 50000 nM for glucocorticoid, mineralocorticoid, androgen and farnesoid X receptors .

     Z-Guggulsterone Chemical Structure
  66. GC62480 Zandelisib Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic. Zandelisib Chemical Structure
  67. GC37970 ZLN024 An allosteric activator of AMPK ZLN024 Chemical Structure
  68. GC12162 ZLN024 hydrochloride

    novel AMPK allosteric activator

     ZLN024 hydrochloride Chemical Structure
  69. GC19540 α-Linolenic Acid An essential fatty acid found in leafy green vegetables α-Linolenic Acid Chemical Structure

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