Stem Cell
- CK1(7)
- EZH2(15)
- GSK-3(56)
- HSC(8)
- iPSC(11)
- Hedgehog(41)
- Notch(42)
- Smoothened(38)
- Wnt/β-catenin(128)
- Hippo Signaling(5)
- Cancer stem cell(23)
- MST1/2(1)
- ESC(1)
- Casein Kinase(33)
- Oct3/4(5)
- Porcupine(6)
- YAP(22)
Products for Stem Cell
- Cat.No. Product Name Information
- GC11548 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
-
GC13576
TC-G 24
GSK-3β inhibitor
- GC31268 tCFA15 tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.
- GC10440 TCS 183 competitive inhibitor of GSK-3β (Ser9) phosphorylation
- GC11515 TCS 184 Scrambled control peptide for use with TCS 183
- GC11627 TCS 2002 TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM.
- GC13301 TCS 2210 Inducer of neuronal differentiation in mesenchymal stem cells (MSCs)
- GC65889 TDI-011536 TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
- GC14840 TDZD-8 GSK-3β inhibitor
- GC65185 TEAD-IN-2 TEAD-IN-2 is a novel, orally active inhibitor of transcriptional enhancer associate domain (TEAD) and modulates TEAD by ubiquitination and/or degradation by compounds. TEAD-IN-2 can be used for the research of a variety of diseases, disorders or conditions associated with TEAD.
-
GC70003
TEAD-IN-3
TEAD-IN-3 (compound I-177) is an effective inhibitor of the TEAD transcription factor. TEAD-IN-3 can be used for research on proliferative diseases such as cancer.
- GC39159 Tegatrabetan Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1).
- GC62394 Teplinovivint Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor.
- GC14465 Tideglusib non-ATP-competitive GSK-3β inhibitor
- GC64131 TMX-4116 TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.
- GC45090 Triparanol Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.
- GC14037 Triptonide A diterpenoid with diverse biological activities
-
GC17868
TWS119
GSK-3β inhibitor
-
GC15284
U 18666A
U18666A can inhibit 3β-hydroxysterol-Δ (24)-reductase (DHCR24) activity, thereby preventing cholesterol outflow from late endosomes and lysosomes.
- GC17535 UM 191 UM 191
- GC11424 Valproic acid HDAC1 inhibitor
- GC45137 Valproic Acid Acyl-D-Glucuronide Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid.
- GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
- GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
- GC14482 Verteporfin Verteporfin is a potent inhibitor of PD-L1 expression used for treatment in the age-related macular degeneration , port-wine stain birthmarks and cancer.
- GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
- GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
-
GC70131
VT02956
VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1 and 0.52 nM for LATS2). It targets the Hippo signaling pathway and inhibits the growth of ER+ breast cancer cell lines and tumor organoids derived from patients, as well as ESR1 expression.
- GC63257 VT103 VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer.
-
GC70132
VT104
VT104 is an orally effective inhibitor of YAP/TAZ. It prevents the palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in cancer research.
- GC62524 VT107 VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.
-
GC50077
WAY 316606 hydrochloride
Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
- GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.
- GC15753 WAY-262611 β-Catenin agonist
-
GC70143
WIC1
WIC1 is an effective Wnt inhibitor that can be used in cancer research.
- GC11674 WIKI4 A potent TNKS1/2 inhibitor
- GC12133 Windorphen Wnt inhibitor
- GC17764 Wnt agonist 1 Wnt agonist 1 is a potent and cell-permeable Wnt signaling activator. Wnt agonist 1 induces TCF-dependent transcriptional activity with an EC50of 700 nM.
-
GC70148
Wnt pathway activator 2
Wnt pathway activator 2 is an effective Wnt activator with an EC50 value of 13 nM. For more information, please refer to patent WO2012024404A1, compound 2.
- GC13658 Wnt-C59 PORCN inhibitor,highly potent and selective
- GC37937 Wnt/β-catenin agonist 1 Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM.
- GC63695 Wnt/β-catenin agonist 2 Wnt/β-catenin agonist 2 is a potent Wnt agonist.
- GC66039 Wnt/β-catenin agonist 3 Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis.
-
GC70149
Wnt/β-catenin agonist 3 hydrochloride
Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signaling pathway activator. Wnt/β-catenin agonist 3 (compound 98) can be used for research on osteoporosis.
- GC68028 Wnt/β-catenin agonist 4
- GN10017 Wogonin
- GC12781 XAV-939 XAV-939 selectively inhibits β-catenin-mediated transcription.
-
GC11245
XMU-MP-1
MST1/2 inhibitor, potent and selective
- GC26088 YAP-TEAD Inhibitor 1 (Peptide 17) YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
- GC39461 YAP-TEAD-IN-1 TFA YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of?YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM).
- GC65131 YAP/TAZ inhibitor-2 YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity.
- GC63303 YB-0158 YB-0158 is known as Wnt pathway inhibitor 2.
- GC50703 Yhhu 3792
- GC17671 YO-01027 (Dibenzazepine, DBZ) An inhibitor of γ-secretase
- GC45596 YW1128
- GC15896 Z-Ile-Leu-aldehyde potent gamma-Secretase inhibitor
-
GC18533
ZLDI-8
Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.
- GC63560 ZW4864 ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.
- GC63559 ZW4864 free base ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.