Ubiquitination/ Proteasome
- Autophagy(1071)
- DUB(20)
- E1 Activating(1)
- E2 conjugating(1)
- E2 Ligases(0)
- E3 Ligase(8)
- Proteasome(96)
- p97(11)
- Mitophagy(77)
- ULK(9)
Products for Ubiquitination/ Proteasome
- Cat.No. Product Name Information
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GN10103
Neferine
4′′-O-Methylliensinine, (–)-Neferine
- GC13793 NH125 Selective eEF-2 kinase inhibitor
- GC65072 Niacin-13C6
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GC10678
Nicardipine HCl
RS 69216
Nicardipine HCl (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. -
GC44400
Niclosamide (ethanolamine salt)
BAY-73, BAY-6076, Bayluscide, HL 2448
Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research. - GC36736 Nicodicosapent Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
- GC13206 Nicotinic Acid Nicotinic Acid (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans.
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GC34686
Nidufexor
Nidufexor
An FXR partial agonist
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GC15024
Nifedipine
BAY 1040
L-type calcium channel blocker - GC14237 Nilotinib monohydrochloride monohydrate A Bcr-Abl inhibitor
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GC16587
Nimodipine
BAY-e 9736
Calcium Channel inhibitor & Autophagy activator -
GC11618
Nitazoxanide
NSC 697855, NTZ
Antiprotozoal agent - GC16999 Nitrendipine Calcium channel blocker
- GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate) Nitroprusside disodium dehydrate (Sodium nitroprusside dihydrate) is a vasodilator that available for the research of acute hypertension, heart failure.
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GC11365
Nitroxoline
8-Hydroxy-5-nitroquinoline, 5-Nitro-8-hydroxyquinoline
antibacterial agent - GC39411 NL-1 NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 ?M and 56.26 ?M, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway.
- GC32874 NMS-859 NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
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GC17250
NMS-873
VCP Inhibitor III
VCP/p97 inhibitor,selective and allosteric -
GN10325
Nobiletin
NSC 76751, NSC 618903
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GC14075
Nocodazole
NSC 238159, Oncodazole, R 17934
A tubulin production inhibitor,anti-neoplastic agent - GC50113 Noradrenaline bitartrate Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist.
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GC10976
Noradrenaline bitartrate monohydrate
Arterenol, Levarterenol, NE, L-Noradrenaline
Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. -
GC18089
Nordihydroguaiaretic acid
NDGA, NSC 4291
A non-selective LO inhibitor - GC30744 Norepinephrine (Adrenor) Norepinephrine (Adrenor) (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist.
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GC36758
Norepinephrine hydrochloride
(±)-Arterenol, DL-Noradrenaline, DL-Norepinephrine, (±)-Noradrenaline, NSC 7930
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. - GC64076 Nortriptyline Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression.
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GC11989
Nortriptyline (hydrochloride)
Acetexa,Pamelor®
norepinephrine and serotonin transporters blocker - GC32821 Noscapine ((S,R)-Noscapine)
- GC39023 Notoginsenoside Fc Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation.
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GC16486
Novobiocin Sodium
NSC 2382
aminocoumarin antibiotic
- GC12424 NS 1643 hERG KV11.1 channel activator
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GC44464
NSC 109555
DDUG, NCI C04808
An inhibitor of Chk2 - GC34924 NSC 185058 An inhibitor of ATG4B
- GC15017 NSC 624206 Ubiquitin-activating enzyme (E1) inhibitor
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GC12475
NSC 632839 hydrochloride
F6, Ubiquitin Isopeptidase Inhibitor II
A deubiquitylase and deSUMOylase inhibitor - GC11932 NSC697923 Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective
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GC10470
Nutlin-3a chiral
Nutlin 3a
An inhibitor of the p53-Mdm2 interaction -
GC12963
NVP-AEW541
AEW541
IGF-IR inhibitor, novel, potent and selective -
GC16145
NVP-BGT226
NVP-BGT226 maleate
BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. -
GC11569
Obatoclax mesylate (GX15-070)
GX15070
An antagonist of pro-survival Bcl-2 proteins -
GC14158
Obeticholic Acid
INT 747, Obeticholic Acid
A FXR agonist with anticholeretic activity -
GC64358
Olacaftor
VX-440
Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. -
GC12495
Olanzapine
LY170053
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). - GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine.
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GC17580
Olaparib (AZD2281, Ku-0059436)
AZD 2281, Ku0059436
A PARP inhibitor
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GN10184
Oleanolic acid
Astrantiagenin C, Caryophyllin, Giganteumgenin C, Gledigenin 1, NSC 114945, Oleanoic Acid, Virgaureagenin B
Oleanolic acid is a natural pentacyclic triterpenoid that has long been used as an effective drug in treating hepatitis. Oleanolic acid also exhibits antitumor effects in various cancers.
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GC49815
Oleuropein aglycone
3,4-DHPEA-EA
A polyphenol with diverse biological activities -
GC13166
Omeprazole
OMEP, OMP, OMZ
H+,K+-ATPase inhibitor -
GC36806
Omeprazole D3
OMEP-d3, OMP-d3, OMZ-d3
Omeprazole D3 (H 16868-d3) is deuterium labeled Omeprazole. - GC61155 Omeprazole sodium Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders.
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GC64070
Omeprazole-d3-1
OMEP-d3, OMP-d3, OMZ-d3
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GN10332
Onjisaponin B
(E)-Senegin III
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GC15778
ONX-0914 (PR-957)
ONX-0914,PR-957
A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome -
GC62210
ONX-0914 TFA
PR-957 TFA
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. -
GC15447
Oprozomib (ONX-0912)
ONX-0912,ONX0912,ONX 0912,PR 047,Oprozomib
An orally available proteasome inhibitor - GC39260 OR-1855 OR-1855, an active metabolite of Levosimendan, has effect on human myometrial contractility.
- GN10732 Oroxin B
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GC41625
Oroxylin A
6-Methoxybaicalein
Oroxylin A is a flavonoid that has been found in S.
- GC14071 OSI-027 MTORC1/ mTORC2 inhibitor
- GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor
- GC36821 OSU-T315 OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy.
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GC10579
Ouabain Octahydrate
selective Na+/K+-ATPase inhibitor
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GC17716
Oxaliplatin
Lipoxal, NSC 266046, RP 54780
Oxaliplatin is a cytotoxic chemotherapy drug used to treat cancer. - GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine.
- GC33446 Oxyphenisatin acetate Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.
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GC33464
Oxyresveratrol (trans-Oxyresveratrol)
trans2',3,4',5Tetramethoxystilbene
Oxyresveratrol (trans-Oxyresveratrol) (trans-Oxyresveratrol (trans-Oxyresveratrol)) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). - GC10379 P 22077
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GC12067
P005091
P005091,P5091
P005091 is a potent and selective ubiquitin-specific proteinase 7 (USP7) inhibitor with an EC50 value of 4.2 μM.
- GC33008 p38 MAPK-IN-1 p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM.
- GC30609 p38 MAPK-IN-2 p38 MAPK-IN-2 is an inhibitor of p38 kinase.
- GC31988 p38α inhibitor 1 p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1.
- GC30158 p38-α MAPK-IN-1 p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
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GC38562
P62-mediated mitophagy inducer
PMI
P62-mediated mitophagy inducer is a mitophagy regulator which activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway. -
GC11993
PAC-1
Procaspase activating compound 1
An in vitro procaspase-3 activator -
GC12511
Paclitaxel (Taxol)
NSC 125973
A potent mitotic inhibitor
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GN10498
Paeonol
2'-Hydroxy-4'-methoxyacetophenone, NSC 401442
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GC69650
Paeonol-d3
Paeonol-d3 is deuterated Paeonol.
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GC14304
Palovarotene
Ro 3300074
Selective retinoic acid receptor gamma(RAR-γ) agonist
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GC15814
Pamapimod (R-1503, Ro4402257)
R 1503, Ro 4402257
Pamapimod (R-1503, Ro4402257) (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. -
GC12257
Panobinostat (LBH589)
LBH589
A pan-HDAC inhibitor -
GC12718
Pantoprazole
BY 1023, SKF 96022
H+/K+-ATPase inhibitor - GC36847 Pantoprazole sodium Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI).
- GC36848 Pantoprazole sodium hydrate Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI).
- GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
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GC17229
Paroxetine HCl
BRL 29060A
Paroxetine HCl is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14μM. - GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14μM.
- GN10357 Parthenolide
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GC16327
Pazopanib (GW-786034)
GSK-VEG10003, GW786034B
A multi-kinase inhibitor -
GC12730
Pazopanib Hydrochloride
GW786034;Votrient;Armala;GW 786034;GW-786034
VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor -
GC12205
PD 146176
NSC 168807
PD 146176 is one of the potent and selective inhibitors of reticulocyte 15-LOX-1. - GC16912 PD 150606 An inhibitor of calpains
- GC10561 PD 151746 calpain inhibitor, cell-permeable
- GC17737 PD 169316 P38 MAPK inhibitor
- GC19279 PD-166866 PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.
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GC10397
PD0325901
A MEK inhibitor that sustains stem cell renewal
- GC11015 PD168393 EGFR inhibitor
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GC12819
PD98059
NSC 679828
PD98059 is a potent and selective MEK inhibitor with an IC50 of 2 μM.
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GN10084
Peiminine
Verticinone
- GC11610 Pemetrexed An antifolate with anticancer activity
- GC17694 Pemetrexed disodium hemipenta hydrate