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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GN10103 Neferine Neferine Chemical Structure
  3. GC13793 NH125 Selective eEF-2 kinase inhibitor NH125 Chemical Structure
  4. GC65072 Niacin-13C6 Niacin-13C6 Chemical Structure
  5. GC10678 Nicardipine HCl Nicardipine HCl (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine HCl Chemical Structure
  6. GC44400 Niclosamide (ethanolamine salt) Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research. Niclosamide (ethanolamine salt) Chemical Structure
  7. GC36736 Nicodicosapent Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. Nicodicosapent Chemical Structure
  8. GC13206 Nicotinic Acid Nicotinic Acid (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Nicotinic Acid Chemical Structure
  9. GC34686 Nidufexor

    An FXR partial agonist

     Nidufexor Chemical Structure
  10. GC15024 Nifedipine L-type calcium channel blocker Nifedipine Chemical Structure
  11. GC14237 Nilotinib monohydrochloride monohydrate A Bcr-Abl inhibitor Nilotinib monohydrochloride monohydrate Chemical Structure
  12. GC16587 Nimodipine Calcium Channel inhibitor & Autophagy activator Nimodipine Chemical Structure
  13. GC11618 Nitazoxanide Antiprotozoal agent Nitazoxanide Chemical Structure
  14. GC16999 Nitrendipine Calcium channel blocker Nitrendipine Chemical Structure
  15. GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate) Nitroprusside disodium dehydrate (Sodium nitroprusside dihydrate) is a vasodilator that available for the research of acute hypertension, heart failure. Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate) Chemical Structure
  16. GC11365 Nitroxoline antibacterial agent Nitroxoline Chemical Structure
  17. GC39411 NL-1 NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 ?M and 56.26 ?M, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway. NL-1 Chemical Structure
  18. GC32874 NMS-859 NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 Chemical Structure
  19. GC17250 NMS-873 VCP/p97 inhibitor,selective and allosteric NMS-873 Chemical Structure
  20. GN10325 Nobiletin Nobiletin Chemical Structure
  21. GC14075 Nocodazole A tubulin production inhibitor,anti-neoplastic agent Nocodazole Chemical Structure
  22. GC50113 Noradrenaline bitartrate Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Noradrenaline bitartrate Chemical Structure
  23. GC10976 Noradrenaline bitartrate monohydrate Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Noradrenaline bitartrate monohydrate Chemical Structure
  24. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor Nordihydroguaiaretic acid Chemical Structure
  25. GC30744 Norepinephrine (Adrenor) Norepinephrine (Adrenor) (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine (Adrenor) Chemical Structure
  26. GC36758 Norepinephrine hydrochloride Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine hydrochloride Chemical Structure
  27. GC64076 Nortriptyline Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline Chemical Structure
  28. GC11989 Nortriptyline (hydrochloride) norepinephrine and serotonin transporters blocker Nortriptyline (hydrochloride) Chemical Structure
  29. GC32821 Noscapine ((S,R)-Noscapine) Noscapine ((S,R)-Noscapine) Chemical Structure
  30. GC39023 Notoginsenoside Fc Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc Chemical Structure
  31. GC16486 Novobiocin Sodium

    aminocoumarin antibiotic

     Novobiocin Sodium Chemical Structure
  32. GC12424 NS 1643 hERG KV11.1 channel activator NS 1643 Chemical Structure
  33. GC44464 NSC 109555 An inhibitor of Chk2 NSC 109555 Chemical Structure
  34. GC34924 NSC 185058 An inhibitor of ATG4B NSC 185058 Chemical Structure
  35. GC15017 NSC 624206 Ubiquitin-activating enzyme (E1) inhibitor NSC 624206 Chemical Structure
  36. GC12475 NSC 632839 hydrochloride A deubiquitylase and deSUMOylase inhibitor NSC 632839 hydrochloride Chemical Structure
  37. GC11932 NSC697923 Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective NSC697923 Chemical Structure
  38. GC10470 Nutlin-3a chiral An inhibitor of the p53-Mdm2 interaction Nutlin-3a chiral Chemical Structure
  39. GC12963 NVP-AEW541 IGF-IR inhibitor, novel, potent and selective NVP-AEW541 Chemical Structure
  40. GC16145 NVP-BGT226 BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. NVP-BGT226 Chemical Structure
  41. GC11569 Obatoclax mesylate (GX15-070) An antagonist of pro-survival Bcl-2 proteins Obatoclax mesylate (GX15-070) Chemical Structure
  42. GC14158 Obeticholic Acid A FXR agonist with anticholeretic activity Obeticholic Acid Chemical Structure
  43. GC64358 Olacaftor Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. Olacaftor Chemical Structure
  44. GC12495 Olanzapine Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine Chemical Structure
  45. GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine. Olanzapine D3 Chemical Structure
  46. GC17580 Olaparib (AZD2281, Ku-0059436)

    A PARP inhibitor

     Olaparib (AZD2281, Ku-0059436) Chemical Structure
  47. GN10184 Oleanolic acid Oleanolic acid Chemical Structure
  48. GC49815 Oleuropein aglycone A polyphenol with diverse biological activities Oleuropein aglycone Chemical Structure
  49. GC13166 Omeprazole H+,K+-ATPase inhibitor Omeprazole Chemical Structure
  50. GC36806 Omeprazole D3 Omeprazole D3 (H 16868-d3) is deuterium labeled Omeprazole. Omeprazole D3 Chemical Structure
  51. GC61155 Omeprazole sodium Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium Chemical Structure
  52. GC64070 Omeprazole-d3-1 Omeprazole-d3-1 Chemical Structure
  53. GN10332 Onjisaponin B Onjisaponin B Chemical Structure
  54. GC15778 ONX-0914 (PR-957) A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome ONX-0914 (PR-957) Chemical Structure
  55. GC62210 ONX-0914 TFA ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA Chemical Structure
  56. GC15447 Oprozomib (ONX-0912) An orally available proteasome inhibitor Oprozomib (ONX-0912) Chemical Structure
  57. GC39260 OR-1855 OR-1855, an active metabolite of Levosimendan, has effect on human myometrial contractility. OR-1855 Chemical Structure
  58. GN10732 Oroxin B Oroxin B Chemical Structure
  59. GC41625 Oroxylin A

    Oroxylin A is a flavonoid that has been found in S.

     Oroxylin A Chemical Structure
  60. GC14071 OSI-027 MTORC1/ mTORC2 inhibitor OSI-027 Chemical Structure
  61. GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor OSU-03012 (AR-12) Chemical Structure
  62. GC36821 OSU-T315 OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy. OSU-T315 Chemical Structure
  63. GC10579 Ouabain Octahydrate

    selective Na+/K+-ATPase inhibitor

     Ouabain Octahydrate Chemical Structure
  64. GC17716 Oxaliplatin Oxaliplatin is a cytotoxic chemotherapy drug used to treat cancer. Oxaliplatin Chemical Structure
  65. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Chemical Structure
  66. GC33446 Oxyphenisatin acetate Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative. Oxyphenisatin acetate Chemical Structure
  67. GC33464 Oxyresveratrol (trans-Oxyresveratrol) Oxyresveratrol (trans-Oxyresveratrol) (trans-Oxyresveratrol (trans-Oxyresveratrol)) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol (trans-Oxyresveratrol) Chemical Structure
  68. GC10379 P 22077 P 22077 Chemical Structure
  69. GC12067 P005091

    P005091 is a potent and selective ubiquitin-specific proteinase 7 (USP7) inhibitor with an EC50 value of 4.2 μM.

     P005091 Chemical Structure
  70. GC33008 p38 MAPK-IN-1 p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 Chemical Structure
  71. GC30609 p38 MAPK-IN-2 p38 MAPK-IN-2 is an inhibitor of p38 kinase. p38 MAPK-IN-2 Chemical Structure
  72. GC31988 p38α inhibitor 1 p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1. p38α inhibitor 1 Chemical Structure
  73. GC30158 p38-α MAPK-IN-1 p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. p38-α MAPK-IN-1 Chemical Structure
  74. GC38562 P62-mediated mitophagy inducer P62-mediated mitophagy inducer is a mitophagy regulator which activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer Chemical Structure
  75. GC11993 PAC-1 An in vitro procaspase-3 activator PAC-1 Chemical Structure
  76. GC12511 Paclitaxel (Taxol)

    A potent mitotic inhibitor

     Paclitaxel (Taxol) Chemical Structure
  77. GN10498 Paeonol Paeonol Chemical Structure
  78. GC69650 Paeonol-d3

    Paeonol-d3 is deuterated Paeonol.

     Paeonol-d3 Chemical Structure
  79. GC14304 Palovarotene

    Selective retinoic acid receptor gamma(RAR-γ) agonist

     Palovarotene Chemical Structure
  80. GC15814 Pamapimod (R-1503, Ro4402257) Pamapimod (R-1503, Ro4402257) (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod (R-1503, Ro4402257) Chemical Structure
  81. GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor Panobinostat (LBH589) Chemical Structure
  82. GC12718 Pantoprazole H+/K+-ATPase inhibitor Pantoprazole Chemical Structure
  83. GC36847 Pantoprazole sodium Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium Chemical Structure
  84. GC36848 Pantoprazole sodium hydrate Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium hydrate Chemical Structure
  85. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  86. GC17229 Paroxetine HCl Paroxetine HCl is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14μM. Paroxetine HCl Chemical Structure
  87. GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14μM. Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Chemical Structure
  88. GN10357 Parthenolide Parthenolide Chemical Structure
  89. GC16327 Pazopanib (GW-786034) A multi-kinase inhibitor Pazopanib (GW-786034) Chemical Structure
  90. GC12730 Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor Pazopanib Hydrochloride Chemical Structure
  91. GC12205 PD 146176 PD 146176 is one of the potent and selective inhibitors of reticulocyte 15-LOX-1. PD 146176 Chemical Structure
  92. GC16912 PD 150606 An inhibitor of calpains PD 150606 Chemical Structure
  93. GC10561 PD 151746 calpain inhibitor, cell-permeable PD 151746 Chemical Structure
  94. GC17737 PD 169316 P38 MAPK inhibitor PD 169316 Chemical Structure
  95. GC19279 PD-166866 PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM. PD-166866 Chemical Structure
  96. GC10397 PD0325901

    A MEK inhibitor that sustains stem cell renewal

     PD0325901 Chemical Structure
  97. GC11015 PD168393 EGFR inhibitor PD168393 Chemical Structure
  98. GC12819 PD98059

    PD98059 is a potent and selective MEK inhibitor with an IC50 of 2 μM.

     PD98059 Chemical Structure
  99. GN10084 Peiminine Peiminine Chemical Structure
  100. GC11610 Pemetrexed An antifolate with anticancer activity Pemetrexed Chemical Structure
  101. GC17694 Pemetrexed disodium hemipenta hydrate Pemetrexed disodium hemipenta hydrate Chemical Structure

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