Stem Cell
- CK1(7)
- EZH2(15)
- GSK-3(56)
- HSC(8)
- iPSC(11)
- Hedgehog(41)
- Notch(42)
- Smoothened(38)
- Wnt/β-catenin(128)
- Hippo Signaling(5)
- Cancer stem cell(23)
- MST1/2(1)
- ESC(1)
- Casein Kinase(33)
- Oct3/4(5)
- Porcupine(6)
- YAP(22)
Products for Stem Cell
- Cat.No. Product Name Information
- GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram
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GC31794
Methyl vanillate
Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator.
- GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor
- GC17468 ML 239 inhibitor of the breast cancer stem cells
- GC17339 ML-243 inhibitor of cancer stem cells
- GC44213 ML115 Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.
- GC18616 MMP-8 Inhibitor I MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.
- GC44245 MoTP MoTP, known more formally as 4-(4-morpholinobutylthio)phenol, is used to ablate larval melanocytes in zebrafish in order to study melanocyte regeneration.
- GC12192 MRT 10 MRT 10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT 10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT 10 can be used for the research of cancer.
- GC64419 MRT-14 MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling.
- GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
- GC33114 MRT-83 MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.
- GC63863 MRT-83 hydrochloride MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
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GC44250
MS351
MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.
- GC65993 MSC-4106 MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model.
- GC63088 MYF-01-37 MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction.
- GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.
- GC44458 N-Palmitoyl-L-Aspartate N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog.
- GC44321 Nat-20(S)-yne Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.
- GC19260 NCB-0846 NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM.
- GC36708 NCC007 NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively.
- GC64837 Nefopam D3 hydrochloride
- GC11775 Nefopam HCl Nefopam HCl (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain.
- GC38522 Neurodazine Small molecule inducer of neuronal differentiation
- GC11454 Neurodazine Induces neurogenesis of non-pluripotent C2C12 myoblasts
- GC50489 NLS-StAx-h Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions
- GC67737 NLS-StAx-h TFA
- GC64536 Notch 1 TFA Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins.
- GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM.
- GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation.
- GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
- GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM.
- GC44467 NSC 668036 NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain).
-
GC12499
O4I1
potent Oct3/4 inducer
- GC17042 O4I2 Oct3/4 inducer
- GC10151 OAC1 Oct4 activator
- GC17327 OAC2 Oct4 activator
- GC61861 Oct3/4-inducer-1 Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer.
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GC69633
Orobol
Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).
- GC17713 Oxy-16 Oxy-16 is an endogenous metabolic intermediate.
- GC11115 Pamidronate Pamidronate is a drug used to treat a broad spectrum of bone absorption diseases.
- GC49667 PD 168568 (hydrochloride) A dopamine D4 receptor antagonist
- GC16230 PF-04449913 PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
- GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
- GC44612 PF-4800567 PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
- GC36885 PF-5006739 PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively.
- GC13280 PF-5274857 Smo antagonist,potent and selective
- GC10556 PF-670462 An inhibitor of the CK1 isoforms CK1ε and CK1δ
- GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.
- GC38578 PI-828 A PI3K inhibitor
- GC18291 PKF118-310 PKF118-310 (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity.
- GC17107 PluriSIn #1 (NSC 14613) A selective inhibitor of stearoyl-CoA desaturase
- GC16711 PNU 74654 Wnt signaling pathway inhibitor
- GC19299 Porcupine-IN-1 Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
- GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite.
- GC14847 Psoralidin apoptosis inducer
- GC15064 Purmorphamine Purmorphamine is the first small molecule agonist developed for Smoothened protein.
- GC62424 PY-60 PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 ?M.
- GC17607 Pyrintegrin enhances the survival of hESC
- GC32698 Pyrvinium pamoate (Pyrvinium embonate) Pyrvinium pamoate (Pyrvinium embonate) is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling.
- GC17251 QS 11 ARFGAP1 inhibitor,Wnt/beta-catenin pathway modulator
-
GC69802
RA-V
RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75 and 93 ng/mL respectively. RA-V can be used for research on cancer-related signaling pathways.
- GC61233 RBPJ Inhibitor-1 RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation.
- GC25838 RBPJ Inhibitor-1 (RIN1) RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
- GC41468 Retreversine Terminal differentiation of embryonic progenitor cells to form distinct, adult tissues is the hallmark of organogenesis in complex organisms.
- GC37522 RGB-286638 A multi-kinase inhibitor
- GC37523 RGB-286638 free base A multi-kinase inhibitor
-
GC16197
RO4929097
An inhibitor of γ-secretase
- GC18475 Robotnikinin Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development.
- GC44851 Rosiglitazone (potassium salt) Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM).
- GC64922 Rovalpituzumab Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC).
- GC11987 RSC-133 promotes the reprogramming of human somatic cells to pluripotent stem cells
- GC37573 RU-SKI 43 RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity.
- GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase
- GC12068 SAG Hh and Smo agonist
- GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable
- GC37580 SAG hydrochloride SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
- GC62258 SAG-d3 SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM).
- GC50470 SAHM1 Notch pathway inhibitor; prevents Notch complex assembly
- GC14882 Salinomycin A selective cancer stem cell inhibitor
- GC18107 Salinomycin sodium salt A selective cancer stem cell inhibitor
- GC15889 SANT-1 Shh inhibitor,potent and cell-permeable
- GC11193 SANT-2 SANT-2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT-2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers.
- GC32978 Saridegib (IPI-926) Saridegib (IPI-926) is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
- GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7
- GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor
- GC64382 SGC-CK2-1 SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay.
- GC16320 Shz 1 induces phenotypic differentiation
- GC16701 SKI II Sphingosine kinase(SK) inhibitor
- GC16382 SKL2001 An activator of Wnt/β-catenin signaling
- GC12228 SMANT hydrochloride Smoothened (Smo) signaling inhibitor
- GC19336 SR-3029 SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases.
- GC61781 Super-TDU Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model.
- GC37704 Super-TDU (1-31) TFA
- GC34818 Super-TDU 1-31
- GC14441 SW033291 15-PGDH enzyme inhibitor
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GC13825
TA 01
CK1ε, CK1δ,and p38α inhibitor
- GC11635 TA 02 p38 MAPK inhibitor
- GN10797 Tangeretin
- GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor