Angiogenesis
Products for Angiogenesis
- Cat.No. Product Name Information
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GC13812
PCI-32765 (Ibrutinib)
PCI-32765 (Ibrutinib) is an irreversible selective inhibitor of Bruton s tyrosine kinase (BTK) that selectively targets its kinase domain.
- GC12921 PCI-32765 Racemate PCI-32765 Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM.
- GC30155 PCI-33380 PCI-33380 is an irreversible and selective Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).
- GC44584 PD 168368 PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors (Kis = 15-45 nM for rat and human receptors expressed in various cell lines).
- GC34709 PF-06250112 PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively.
- GC62515 Pirtobrutinib Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM.
- GC10235 Plinabulin (NPI-2358) Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells.
- GC67708 PLN-1474
- GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide
- GC47966 PPACK (trifluoroacetate salt) An antithrombin peptide
- GC31339 PRN1008 PRN1008 (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton's Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
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GC47980
Propionyl-L-carnitine-d3 (chloride)
An internal standard for the quantification of propionyl-L-carnitine
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GC69768
Protease-Activated Receptor-1, PAR-1 Agonist
Protease-Activated Receptor-1, PAR-1 Agonist is a selective peptide that activates Protease-Activated Receptor-1 (PAR-1), which corresponds to the PAR1 ligand and selectively mimics the action of thrombin through this receptor.
- GC62469 Protease-Activated Receptor-1, PAR-1 Agonist TFA Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.
- GC61456 Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.
- GC33429 Protease-Activated Receptor-4 Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
- GC49873 Protectin D1 methyl ester An esterified form of protectin D1
- GC32680 PT-2385 PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM.
- GC37034 PT2977 PT2977 (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC).
- GC11031 PX-478 2HCl PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.
- GC37048 QL47 QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses.
- GC49221 QLT0267 An ILK inhibitor
- GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist
- GC37066 Rac-PT2399 A potent and specific HIF-2α inhibitor
- GC40213 Regorafenib-13C-d3 Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS.
- GC38375 Remibrutinib Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM.
- GC10184 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
- GC37524 RGD peptide (GRGDNP) TFA
- GC34402 RGD Trifluoroacetate RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.
- GC16385 RGDS peptide RGDS peptide is an integrin binding sequence that inhibits integrin receptor function.
- GC45798 Rhein-13C4 An internal standard for the quantification of rhein
- GC37541 Risuteganib
- GC17991 RLLFT-NH2 Protease-activated receptor agonist
- GC11230 RN486 Btk inhibitor,potent and selective
- GC62397 RO0270608 RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist.
- GC14795 RWJ 50271 LFA-1/sICAM interaction inhibitor
- GC61777 RWJ-56110 dihydrochloride RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4.
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GC14143
SB273005
An αvβ3 antagonist
- GC10291 SCH 79797 dihydrochloride PAR1 receptor antagonist
- GC63540 SCH79797 SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist.
- GC64571 Sibrafiban Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist.
- GC49713 SIKVAV (acetate) A laminin α1-derived peptide
- GC49358 Sildenafil Chlorosulfonyl An intermediate in the synthesis of sildenafil
- GC48078 Sildenafil-d3 An internal standard for the quantification of sildenafil
- GC62614 SJF620 hydrochloride SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.
- GC14540 SLIGKV-NH2 SLIGKV-NH2 (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.
- GC17514 SLIGRL-NH2 PAR2 activator
- GC37672 Spebrutinib besylate Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays.
- GC40963 Spirolaxine Spirolaxine is a long-chain phthalide produced by the fungus S.
- GC31993 SR121566A SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.
- GC44956 Streptochlorin Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp.
- GC45688 STX140 An estrogen sulfamate
- GC44966 Sucrose octasulfate (potassium salt) Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.
- GC32876 SYP-5 A HIF-1 inhibitor
- GC64120 TAK-020 TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.
- GC12037 TC-I 15 α2β1 integrin inhibitor
- GC18025 TCS 2314 integrin very late antigen-4 (VLA-4; α4β1) antagonist
- GC61316 tcY-NH2 TFA tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide.
- GC61323 Tetrac Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.
- GC17444 TFLLR-NH2 PAR1 selective agonist
- GC37770 TFLLR-NH2(TFA) TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.
- GP10085 Thrombin Receptor Activator for Peptide 5 (TRAP-5)
- GC10140 Thrombin Receptor Agonist Peptide Thrombin Receptor Agonist Peptide is a synthetic thrombin receptor agonist peptide.
- GC32945 THS-044 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.
- GC45054 Tie2 Inhibitor 7 Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM..
- GC32228 Tilorone dihydrochloride An interferon-inducing antiviral agent
- GC33821 Tirabrutinib (ONO-4059) Tirabrutinib (ONO-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM.
- GC34097 Tirabrutinib hydrochloride (ONO-4059 (hydrochloride)) Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM.
- GC13255 Tirofiban selective platelet GPIIb/IIIa antagonist
- GC11371 Tirofiban hydrochloride monohydrate A GPIIb/IIIa antagonist
- GC63229 TL-895 TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively.
- GC37801 TM6089 TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia.
- GC63232 Tolebrutinib Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
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GC31498
TP0463518
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor
- GC37818 TR-14035 TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively.
- GC48195 trans-trismethoxy Resveratrol-d4 An internal standard for the quantification of trans-trismethoxy resveratrol
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GC11662
TRAP-6
PAR1 agonist
- GC65529 TRAP-6 amide TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.
- GC48210 TRX-818 (sodium salt) An anticancer compound
- GC37852 UDM-001651 UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM).
- GC16811 Vadadustat HIF-PH inhibitor
- GC63490 Valategrast Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist.
- GC64212 Valategrast hydrochloride Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist.
- GC45769 Vandetanib-d6 An internal standard for the quantification of vandetanib
- GC37889 VCE-004.8 VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist.
- GC34077 Vecabrutinib (SNS-062) Vecabrutinib (SNS-062) (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib (SNS-062) shows an IC50 of 24 nM for ITK.
- GC34211 Vedolizumab Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
- GC11727 VKGILS-NH2 control peptide for SLIGKV-NH2, PAR1 agonist
- GC17545 Vorapaxar PAR-1 antagonist,potent and orally active
- GC64347 Vorapaxar sulfate Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM).
- GC34075 Zanubrutinib (BGB-3111) Zanubrutinib (BGB-3111) (BGB-3111) is a selective Bruton tyrosine kinase (Btk) inhibitor.
- GC37960 Zaurategrast Zaurategrast (CT7758) is a potent and oral-effective α4-integrin inhibitor.
- GC37961 Zaurategrast ethyl ester Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.
- GC37962 Zaurategrast ethyl ester sulfate Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.
- GC37966 ZINC13466751 ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M.