Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(26)
- Aurora Kinase(47)
- Cdc42(4)
- Cdc7(4)
- Chk(16)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(91)
- E1 enzyme(1)
- G-quadruplex(14)
- Haspin(7)
- HMTase(1)
- Kinesin(26)
- Ksp(6)
- Microtubule/Tubulin(243)
- Mps1(15)
- Mitotic(11)
- RAD51(18)
- ROCK(71)
- Rho(13)
- PERK(11)
- PLK(37)
- PTEN(8)
- Wee1(7)
- PAK(21)
- Arp2/3 Complex(8)
- Dynamin(12)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(26)
- G2/S(10)
- Genotoxic Stress(18)
- Inositol Phosphates(18)
- Proteolysis(99)
- Cytoskeleton & Motor Proteins(53)
- Cellular Chaperones(8)
Products for Cell Cycle/Checkpoint
- Cat.No. Product Name Information
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GC40702
α-D-Galactopyranosylphenyl isothiocyanate
α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.
- GC41676 (±)-Nornicotine (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist.
- GC49482 (±)-Nornicotine-d4 An internal standard for the quantification of (±)-nornicotine
- GC41684 (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups.
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GC40802
(±)12(13)-DiHOME
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
- GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
- GC45890 (+)-Abscisic Acid-d6 An internal standard for the quantification of (+)-abscisic acid
- GC62728 (1E)-CFI-400437 dihydrochloride (1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
- GC41268 (E)-2-Hexadecenal Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase.
- GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.
- GC46335 (E)-Fenpyroximate A phenoxypyrazole acaricide
- GC10419 (R)-CCG-1423 Rho inhibitor
- GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
- GC41719 (R)-nitro-Blebbistatin (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin.
- GC46347 (S)-(+)-Methoprene An insect growth regulator and Met agonist
- GC41557 (S)-3'-amino Blebbistatin (S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
- GC41484 (S)-3'-hydroxy Blebbistatin (S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
- GC52192 (S)-4'-nitro-Blebbistatin (S)-4'-nitro-Blebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies.
- GC14497 (S)-CCG-1423 Rho inhibitor
- GC34999 (S)-Ceralasertib (S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM.(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition.
- GC46351 (S)-CR8 An inhibitor of cyclin-dependent kinases
- GC41737 (S)-Glycyl-H-1152 (hydrochloride) Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC41739 (S)-nitro-Blebbistatin (S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
- GC18275 1,2-Dihexadecyl-sn-glycero-3-PC 1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions.
- GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
- GC46379 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt) 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt) is a ubstitute for Phosphoserine/phosphatidylserine.
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GC41823
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
- GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose A ManNAc analog and building block
- GC19528 1,4-Benzoquinone A toxic metabolite of benzene
- GC18726 1-Methyl-1,4-dihydronicotinamide 1-Methyl-1,4-dihydronicotinamide is a derivative of nicotinamide .
- GC49736 10-acetyl Docetaxel 10-acetyl Docetaxel (10-Acetyl docetaxel) is an analog of Docetaxel, with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity.
- GC12954 10-DAB (10-Deacetylbaccatin) An inhibitor of microtubule assembly
- GC35044 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.
- GC35045 10-Oxo Docetaxel A docetaxel degradation product
- GC17295 10058-F4 C-Myc-Max dimerization inhibitor
- GC63576 10074-A4 10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects.
- GC14918 10074-G5 c-Myc inhibitor
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GC40448
12(S)-HETE
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
- GC46434 13C15-Nivalenol An internal standard for the quantification of nivalenol
- GC49390 13C6-4-Nitroaniline An internal standard for the quantification of 4-nitroaniline
- GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N.
- GC48423 19-O-Acetylchaetoglobosin A A fungal metabolite with actin polymerization inhibitory and cytotoxic activities
- GC42151 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) 2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis.
- GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea.
- GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols
- GC45324 2,5-dimethyl Celecoxib
- GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline A food-derived carcinogen
- GC52029 2-Aminoflubendazole
- GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
- GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity..
- GC52140 2-Methoxyhydroquinone
- GC42161 2H-Cho-Arg (trifluoroacetate salt) 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
- GC40618 3',4',7-Trihydroxyisoflavone 3',4',7-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 3',4',7-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities.
- GC45332 3'-Dephosphocoenzyme A An intermediate in the biosynthesis of CoA
- GC42239 3,6-diacetoxy Phthalonitrile 3,6-diacetoxy Phthalonitrile is a cell-permeable fluorescent probe.
- GC12314 3-(4-Pyridyl)indole ROCK-I inhibitor
- GC46582 3-Acetyldeoxy Nivalenol-13C17 An internal standard for the quantification of 3-acetyldeoxy nivalenol
- GC52129 3-Amino-5-hydroxybenzoic Acid
- GC15389 360A
- GC10115 360A iodide
- GC14186 3MB-PP1 polo-like kinase 1 (Plk1) allele inhibitor,ATP-competitive
- GC45354 4β-Hydroxywithanolide E A withanolide with anti-inflammatory and anticancer activities
- GC17271 4'-Demethylepipodophyllotoxin An inhibitor of tubulin polymerization
- GC46606 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline A heterocyclic building block
- GC46635 4-deoxy Nivalenol-13C15 An internal standard for the quantification of 4-deoxy nivalenol
- GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
- GC42449 4-Methylumbelliferyl-α-L-Iduronide (free acid) 4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate.
- GC49244 4-oxo Isotretinoin An active metabolite of isotretinoin
- GC52365 4-tert-Octylphenol monoethoxylate An alkylphenolethoxylate and a degradation product of non-ionic surfactants
- GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
- GC46681 5-Bromouridine A brominated uridine analog
- GC45357 5-Chlorouracil
- GC41156 5-Octyl D-glutamate 5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases.
- GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.
- GC42586 6α-hydroxy Paclitaxel 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8.
- GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone
- GC46721 6-Chloro-2-fluoropurine A heterocyclic building block
- GC48721 6-O-Demethyl Griseofulvin A metabolite of griseofulvin
- GC15478 6H05 K-Ras inhibitor
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GC40202
7α-hydroxy Cholesterol-d7
7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.
- GC46733 7,12-Dimethylbenz[a]anthracene 7,12-Dimethylbenz[a]anthracene has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). 7,12-Dimethylbenz[a]anthracene is used to induce tumor formation in various rodent models.
- GC35188 7-Epi-10-oxo-docetaxel 7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC).
- GC35189 7-Epi-docetaxel 7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.
- GN10625 7-Epitaxol
- GC42610 7-hydroxy Pestalotin 7-hydroxy Pestalotin is a fungal metabolite originally isolated from Penicillium.
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GC42616
7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S.
- GC35197 7-xylosyltaxol A taxane with microtubule disruptor and anticancer activities
- GC52126 8-chloro Caffeine
- GC40844 9-(2,2-Dicyanovinyl)julolidine 9-(2,2-Dicyanovinyl)julolidine (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization.
- GC48986 9-hydroxy Stearic Acid A hydroxy fatty acid
- GC42665 AAF-CMK (trifluoroacetate salt) Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.
- GC35216 AAPK-25 AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM.
- GC25025 Abraxane Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
- GC15875 ABT-751 (E7010) ABT-751 (E7010)(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.
- GC42683 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1).
- GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase
- GC42684 Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1).
- GA20494 Ac-Asp-Glu-Val-Asp-pNA The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm.