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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC44348 N-desmethyl Bendamustine

    nor-Bendamustine

     N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine. N-desmethyl Bendamustine Chemical Structure
  3. GC39498 N-Nitroso-N-methylurea N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane. N-Nitroso-N-methylurea Chemical Structure
  4. GC19566 N-Nitrosodiethylamine (950mg/mL) N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. N-Nitrosodiethylamine (950mg/mL) Chemical Structure
  5. GC69577 N-Nitrosodiethylamine-d10

    Diethylnitrosamine-d10

    N-Nitrosodiethylamine-d10 is the deuterated form of N-Nitrosodiethylamine. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent carcinogen belonging to the group of nitrosamines. It is mainly found in tobacco smoke, water, cheddar cheese, pickled foods, fried foods and many alcoholic beverages. N-Nitrosodiethylamine is responsible for changes in nucleases involved in DNA repair/replication. It can cause various tumors in all animals with major target organs being the nasal cavity, trachea, lungs, esophagus and liver.

     N-Nitrosodiethylamine-d10 Chemical Structure
  6. GC69589 N-Propargyladenosine

    N-Propargyladenosine is an adenosine analogue. Adenosine analogues are mostly used as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Some popular products in this series include Adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine.

     N-Propargyladenosine Chemical Structure
  7. GC69525 N1-Methyl-2'-deoxyadenosine

    N1-Methyl-2'-deoxyadenosine, DNA adduct is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing cell apoptosis, etc.

     N1-Methyl-2'-deoxyadenosine Chemical Structure
  8. GC66075 N1-Methylpseudouridine-5′-triphosphate trisodium

    1-Methylpseudouridine-5′-triphosphate trisodium

     N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability. N1-Methylpseudouridine-5′-triphosphate trisodium Chemical Structure
  9. GC66325 N2-Acetylguanine N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent. N2-Acetylguanine Chemical Structure
  10. GC65127 N2-Methylguanosine N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's. N2-Methylguanosine Chemical Structure
  11. GC36681 N6,N6-Dimethyladenosine

    6-N,N-Dimethyladenosine, 6-DMA, m62A

     N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Guérin tRNA. N6,N6-Dimethyladenosine Chemical Structure
  12. GC65241 N6-Etheno 2'-deoxyadenosine N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues. N6-Etheno 2'-deoxyadenosine Chemical Structure
  13. GC65561 N6-Methyl-dA phosphoramidite N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides. N6-Methyl-dA phosphoramidite Chemical Structure
  14. GC34156 Namitecan (ST-1968)

    ST-1968

     Namitecan (ST-1968) is a potent topoisomerase I inhibitor, with antitumor property. Namitecan (ST-1968) Chemical Structure
  15. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3 Chemical Structure
  16. GC36691 Nanatinostat

    CHR-3996

     Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Nanatinostat Chemical Structure
  17. GC36708 NCC007 NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 Chemical Structure
  18. GC63653 NCGC00029283 NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively. NCGC00029283 Chemical Structure
  19. GC64393 NCT02 NCT02 is a cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. NCT02 has the potential for the research of metastatic colorectal cancer (CRC). NCT02 Chemical Structure
  20. GC15786 Nedaplatin

    NSC 375101

     DNA synthesis inhibitor Nedaplatin Chemical Structure
  21. GC10591 Nelarabine

    GW 506U78, Nelzarabine

     Prodrug of ara-G for T-LBL/T-ALL Nelarabine Chemical Structure
  22. GC45523 Nemorosone   Nemorosone Chemical Structure
  23. GC64493 Neocarzinostatin

    Zinostatin; Vinostatin

    Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs).

     Neocarzinostatin Chemical Structure
  24. GC60268 Neoxanthin Neoxanthin is a major xanthophyll carotenoid and a precursor of the plant hormone abscisic acid in dark green leafy vegetables. Neoxanthin is a potent antioxidant and light-harvesting pigment. Neoxanthin induces apoptosis and has anticancer actions. Neoxanthin Chemical Structure
  25. GC65202 Nesuparib

    JPI-547/OCN-201

     Nesuparib is a potent inhibitor of PARP. Nesuparib Chemical Structure
  26. GC13764 Nexturastat A HDAC6 inhibitor,highly potent and selective Nexturastat A Chemical Structure
  27. GC36732 NG 52

    Compound 52

     NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p. NG 52 Chemical Structure
  28. GC61956 NHC-diphosphate NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form. NHC-diphosphate Chemical Structure
  29. GC61130 NHC-triphosphate

    NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form.

     NHC-triphosphate Chemical Structure
  30. GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form. NHC-triphosphate tetrasodium Chemical Structure
  31. GC36743 Nimustine hydrochloride

    ACNU, NSC-D 245382

     Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas. Nimustine hydrochloride Chemical Structure
  32. GC34120 Niraparib R-enantiomer (MK 4827 (R-enantiomer))

    MK 4827 (R-enantiomer)

     Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. Niraparib R-enantiomer (MK 4827 (R-enantiomer)) Chemical Structure
  33. GC64559 NITD-2 NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 Chemical Structure
  34. GC19506 NITD008

    7-Deaza-2'-C-acetylene-adenosine

    NITD008 is a potent and selective flaviviruse inhibitor which can inhibit Dengue Virus Type 2 (DENV-2) with an EC50 of 0.64 μM.

     NITD008 Chemical Structure
  35. GC44408 Nitrosobenzene

    NSC 66479

     Nitrosobenzene is a spin trap that has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils. Nitrosobenzene Chemical Structure
  36. GC32964 NKL 22

    Histone Deacetylase Inhibitor IV

     A selective HDAC1/3 inhibitor NKL 22 Chemical Structure
  37. GC19263 NKP-1339

    KP1339

     NKP-1339(IT-139) is a ruthenium(iii) coordination anticancer compound based on target to transferrin. NKP-1339 Chemical Structure
  38. GC19264 NMS-P118 NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy. NMS-P118 Chemical Structure
  39. GC36751 NMS-P515 NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity. NMS-P515 Chemical Structure
  40. GC14075 Nocodazole

    NSC 238159, Oncodazole, R 17934

     A tubulin production inhibitor,anti-neoplastic agent Nocodazole Chemical Structure
  41. GC44438 Nogalamycin

    NSC 70845, U 15167

     Nogalamycin is an anthracycline originally isolated from S. Nogalamycin Chemical Structure
  42. GC62679 NSAH NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively. NSAH Chemical Structure
  43. GC63874 NSC 107512 NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors. NSC 107512 Chemical Structure
  44. GC12475 NSC 632839 hydrochloride

    F6, Ubiquitin Isopeptidase Inhibitor II

     A deubiquitylase and deSUMOylase inhibitor NSC 632839 hydrochloride Chemical Structure
  45. GC15503 NSC 687852 (b-AP15)

    b-AP15

     An inhibitor of the deubiquitinases USP14 and UCHL5 NSC 687852 (b-AP15) Chemical Structure
  46. GC69598 NSC 80467

    NSC 80467 is a DNA damaging agent that selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and induces two markers of DNA damage, γH2AX and pKAP1.

     NSC 80467 Chemical Structure
  47. GC64103 NSC639828 NSC639828 is a potent inhibitor of DNA polymerase α with an IC50 of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease. NSC639828 Chemical Structure
  48. GC34111 NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde) NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde) (NSC95682) is an IRE-1α inhibitor with an IC50 of 0.08 μM, extracted from patent WO 2008154484 A1, IRE-lα inhibitor compound 3-5. NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde) Chemical Structure
  49. GC12332 NU 7026

    DNAPK Inhibitor II, LY293646

     DNPK inhibitor,ATP-competitive and potent NU 7026 Chemical Structure
  50. GC19267 NU2058

    O6-(Cyclohexylmethyl)guanine

     NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. NU2058 Chemical Structure
  51. GC34692 NU6140 A Cdk2 inhibitor NU6140 Chemical Structure
  52. GC32829 NU6300 NU6300 is a covalent, irreversible and ATP-competitive CDK2 inhibitor with an IC50 value of 0.16 μM. NU6300 can be used for the research of eukaryotic cell cycle- and transcription-related. NU6300 Chemical Structure
  53. GC11251 NU7441 (KU-57788)

    KU 57788; NU-7441;KU57788;NU7441;NU 7441

     NU7441 (KU-57788) (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. NU7441 (KU-57788) is an NHEJ pathway inhibitor. NU7441 (KU-57788) also inhibits PI3K and mTOR with IC50s of 5.0 and 1.7 μM, respectively. NU7441 (KU-57788) Chemical Structure
  54. GC33956 Nucleoside-Analog-1 Nucleoside-Analog-1 is a 4′-Azidocytidine analogue against Hepatitis C virus replication. Nucleoside-Analog-1 Chemical Structure
  55. GC33959 Nucleoside-Analog-2 Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication. Nucleoside-Analog-2 Chemical Structure
  56. GC13925 Nullscript negative control of scriptaid, HDAC inhibitor Nullscript Chemical Structure
  57. GC64293 Nusinersen Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein. Nusinersen Chemical Structure
  58. GC34056 NVP-2 NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 ?M, 0.706 ?M, and 0.605 ?M, respectively. NVP-2 induces cell apoptosis. NVP-2 Chemical Structure
  59. GC16959 NVP-LCQ195 NVP-LCQ195 Chemical Structure
  60. GC17555 NVP-TNKS656

    TNKS656

     TNKS2 inhibitor NVP-TNKS656 Chemical Structure
  61. GC63123 NVS-SM2 NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC50 of 2 nM for SMN. NVS-SM2 Chemical Structure
  62. GC62501 OBI-3424

    TH-3424

     OBI-3424 (TH-3424) is a prodrug that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research. OBI-3424 Chemical Structure
  63. GC49743 Octapeptide-2

    KLKKTETQ

     A thymosin β4-derived peptide Octapeptide-2 Chemical Structure
  64. GC69618 Olaparib-d8

    AZD2281-d8; KU0059436-d8

    Olaparib-d8 is the deuterated form of Olaparib (AZD2281). Olaparib is an orally effective PARP inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 5 and 1 nM, respectively. Olaparib is also an activator of autophagy and mitophagy.

     Olaparib-d8 Chemical Structure
  65. GC67906 OM-153 OM-153 Chemical Structure
  66. GC33353 ON-013100 ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression. ON-013100 Chemical Structure
  67. GC15607 ON123300 multi-targeted kinase inhibitor,inhibits CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn ON123300 Chemical Structure
  68. GC69633 Orobol

    Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).

     Orobol Chemical Structure
  69. GC11528 Orotic acid Pyrimidinecarboxylic acid Orotic acid Chemical Structure
  70. GC64296 Orotidine 5′-monophosphate trisodium

    Orotidine monophosphate trisodium; Orotidylic acid trisodium

     Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5′-monophosphate trisodium Chemical Structure
  71. GC11360 ORY-1001

    Iadademstat, RG-6016

     Selective inhibitor of KDM1A. ORY-1001 Chemical Structure
  72. GC12304 OTS514

    TOPK inhibitor,highly potent

     OTS514 Chemical Structure
  73. GC16511 OTS964 OTS964 is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM. OTS964 Chemical Structure
  74. GC69637 OTUB1/USP8-IN-1

    OTUB1/USP8-IN-1 is an effective dual inhibitor of OTUB1 and USP8, with IC50 values of 0.17 and 0.28 nM, respectively. It can be used for cancer research.

     OTUB1/USP8-IN-1 Chemical Structure
  75. GC17716 Oxaliplatin

    Lipoxal, NSC 266046, RP 54780

     Oxaliplatin is a cytotoxic chemotherapy drug used to treat cancer. Oxaliplatin Chemical Structure
  76. GC49251 Oxaliplatin-d10

    Lipoxal-d10

     An internal standard for the quantification of oxaliplatin Oxaliplatin-d10 Chemical Structure
  77. GC17472 Oxamflatin

    Metacept 3

     HADC inhibitor Oxamflatin Chemical Structure
  78. GC14107 Oxolinic acid

    NSC 110364, Urinox

     quinolone antibiotic that inhibits bacterial DNA gyrase Oxolinic acid Chemical Structure
  79. GC10379 P 22077 P 22077 Chemical Structure
  80. GC12067 P005091

    P005091,P5091

    P005091 is a potent and selective ubiquitin-specific proteinase 7 (USP7) inhibitor with an EC50 value of 4.2 μM.

     P005091 Chemical Structure
  81. GC17232 P005672 hydrochloride

    Sarecycline hydrochloride

     P005672 hydrochloride is a narrow-spectrum tetracycline-class antibiotic. P005672 hydrochloride Chemical Structure
  82. GC12011 P276-00

    P276-00

     P276-00 (P276-00) is a potent cyclin-dependent kinase (CDK) inhibitor, which inhibits CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively.P276-00 (P276-00) shows antitumor activity on cisplatin-resistant cells. P276-00 Chemical Structure
  83. GC15421 Palbociclib (PD0332991) Isethionate

    Palbociclib Isethionate

     Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib (PD0332991) Isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. Palbociclib (PD0332991) Isethionate Chemical Structure
  84. GC14762 Palifosfamide

    Isophosphoramide Mustard, NSC 297900

     An active metabolite of ifosfamide Palifosfamide Chemical Structure
  85. GC34071 Pamiparib (BGB-290)

    BGB-290

     Pamiparib (BGB-290) (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC50 values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. Pamiparib (BGB-290) has potent PARP trapping, and capability to penetrate the brain, and can be used for the research of various cancers including the solid tumor. Pamiparib (BGB-290) Chemical Structure
  86. GC14849 Paradol A phenolic ketone with diverse biological activities Paradol Chemical Structure
  87. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  88. GC64579 PARP-1-IN-2 PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis. PARP-1-IN-2 Chemical Structure
  89. GC65927 PARP-2-IN-1 PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM. PARP-2-IN-1 Chemical Structure
  90. GC68006 PARP1-IN-11 PARP1-IN-11 Chemical Structure
  91. GC69660 PARP1-IN-7

    PARP1-IN-7 is an inhibitor of poly ADP-ribose polymerase-1 (PARP1), used as an anticancer agent.

     PARP1-IN-7 Chemical Structure
  92. GC64578 PARP1-IN-8 PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-8 Chemical Structure
  93. GC69657 PARP10-IN-2

    PARP10-IN-2 is an effective inhibitor of mono-ADP-ribosyltransferase PARP10, with an IC50 of 3.64 μM for human PARP10. It also inhibits PARP2 and PARP15, with IC50 values of 27 μM and 11 μM for human PARP2 and human PARP15, respectively.

     PARP10-IN-2 Chemical Structure
  94. GC69658 PARP10-IN-3

    PARP10-IN-3 is a selective mono-ADP-ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. It also inhibits PARP2 and PARP15, with IC50 values of 1.7 μM for both human PARP2 and human PARP15.

     PARP10-IN-3 Chemical Structure
  95. GC68035 PARP10/15-IN-1 PARP10/15-IN-1 Chemical Structure
  96. GC69655 PARP10/15-IN-2

    PARP10/15-IN-2 (Compound 8h) is an effective dual inhibitor of PARP10 and PARP15, with IC50 values of 0.15 μM and 0.37 μM, respectively. It can enter cells and prevent apoptosis.

     PARP10/15-IN-2 Chemical Structure
  97. GC69656 PARP10/15-IN-3

    PARP10/15-IN-3 (Compound 8a) is an effective dual inhibitor of PARP10 and PARP15, with IC50 values of 0.14 μM and 0.40 μM, respectively. It can enter cells and prevent apoptosis.

     PARP10/15-IN-3 Chemical Structure
  98. GC69659 PARP11 inhibitor ITK7

    ITK7

    PARP11 inhibitor ITK7 (ITK7) is an effective and selective inhibitor of PARP11. It can effectively inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for research on cellular localization.

     PARP11 inhibitor ITK7 Chemical Structure
  99. GC69661 PARP7-IN-14

    PARP7-IN-14 (I-1) is an effective selective PARP7 inhibitor with an IC50 value of 7.6 nM. PARP7-IN-14 has anti-cancer activity.

     PARP7-IN-14 Chemical Structure
  100. GC65891 PCLX-001 PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 exhibits anti-tumor activity and inhibits early B-cell receptor (BCR) signaling, can be used to B-cell malignancies research. PCLX-001 Chemical Structure
  101. GC17935 PD 0332991 (Palbociclib) HCl

    PD0332991;PD-0332991;PD 0332991

     Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) HCl has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. PD 0332991 (Palbociclib) HCl Chemical Structure

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