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TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. GC13890 (±)-Palmitoylcarnitine chloride intermediate in mitochondrial fatty acid oxidation
  3. GC16081 (-)-epicatechin inducer of pancreatic β-cell regeneration
  4. GC10603 (-)-epicatechin gallate major catechin in green tea
  5. GC17242 (-)-epigallocatechin green tea epicatechin
  6. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  7. GC14012 (-)-Indolactam V A protein kinase C activator
  8. GC18062 1,2-Dilauroyl-sn-glycerol
  9. GC14134 1,2-Dimyristoyl-sn-glycerol
  10. GC13877 1,2-Dipalmitoyl-sn-glycerol

    weak activator of PKC

  11. GC12662 1,2-Distearoyl-sn-glycerol
  12. GC12172 1-Naphthyl PP1 Src family kinases inhibitor
  13. GC41863 10,11-dehydro Curvularin A natural mycotoxin
  14. GN10444 12-O-tetradecanoyl phorbol-13-acetate An activator of ERK/MAPK
  15. GC13927 A 77-01 Potent ALK5 inhibitor
  16. GC10166 A 83-01 ALK-5 inhibitor
  17. GC35210 A 83-01 sodium salt A potent inhibitor of TGF-β type I receptor ALK5 kinase
  18. GC15579 Adaphostin P210bcr/abl tyrosine kinase inhibitor
  19. GC16475 Afuresertib pan-AKT inhibitor
  20. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.
  21. GC11050 ALK5 Inhibitor II (hydrochloride) ALK5 inhibitor

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