Ubiquitination/ Proteasome
- Autophagy(1374)
- DUB(28)
- E1 Activating(1)
- E2 conjugating(1)
- E2 Ligases(0)
- E3 Ligase(8)
- Proteasome(123)
- p97(12)
- Mitophagy(104)
- ULK(10)
Products for Ubiquitination/ Proteasome
- Cat.No. Product Name Information
- GC13892 C527 Inhibitor of USP1/USF1 complex
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GC17912
C598-0466
USP7 inhibitor
- GC45616 C6 Urea Ceramide An inhibitor of neutral ceramidase
- GC12733 C646 C646, a potent and selective p300/CBP histone acetyltransferase inhibitor (Ki 400 nM), has been shown to have pleiotropic activity, including neuroprotective, anti-cancer and anti-epithelial-mesenchymal transition (anti-EMT) effects..
- GC43105 C8 Ceramide (d18:1.8:0) C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides.
- GC33218 CA-5f A potent late-stage macroautophagy/autophagy inhibitor
- GC62881 CA77.1 CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics.
- GC11765 Cabazitaxel Microtubule associated inhibitor
- GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
- GC10441 Cabergoline potent dopamine receptor agonist
- GC13396 CAL-101 (Idelalisib, GS-1101) A selective PI3K p110δ inhibitor
- GC60668 Calcimycin hemimagnesium Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium).
- GC30990 Calcineurin substrate Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase.
- GC38629 Calcineurin substrate (TFA)
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GC14326
Calmidazolium chloride
Calmodulin antagonist
- GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
- GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
- GC12527 Calpain Inhibitor I, ALLN A non-selective cysteine protease inhibitor
- GC40694 Calpain Inhibitor II Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases.
- GC67908 Calpain-2-IN-1
- GC10342 Calpeptin A calpain inhibitor
- GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.
- GC14065 Capsaicin A terpene alkaloid with diverse biological activities
- GC32815 Capzimin Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.
- GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels
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GC11207
Carboplatin
Antitumor agent that forms platinum-DNA adducts.
- GC15089 Carfilzomib (PR-171) A proteasome inhibitor
- GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib
- GC17341 Carprofen COX inhibitor
- GC14769 Carvedilol Potent β-adrenoceptor and α1-adrenoceptor antagonist
- GC35613 Carvedilol phosphate hemihydrate Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker.
- GC64003 Carvedilol-d4
- GC43189 CAY10681 Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer.
- GC47065 CAY10773 A derivative of sorafenib
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GC16351
CB-5083
p97 inhibitor
-
GC20117
CB-5339
CB-5339 is a second generation, potent and selective, orally bioavailable, ATP-competitive, small molecule inhibitor of valosin containing protein (VCP)/p97 [1,2].
- GC15227 CB-839 CB-839 (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. CB-839 selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. CB-839 inudces autophagy and has antitumor activity.
- GC33006 CCT020312 CCT020312 is a selective EIF2AK3/PERK activator.
- GC15864 CCT128930 AKT inhibitor
- GC11464 CD 437 RARγ-selective agonist,potent and cell-permeable
- GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.
- GC16421 Cediranib (AZD217) Cediranib (AZD217) (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
- GC33004 Cediranib maleate (AZD-2171 maleate) Cediranib maleate (AZD-2171 maleate) (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
- GC15083 Celastrol A triterpenoid antioxidant
- GC12272 CEP-18770 An inhibitor of chymotrypsin-like proteasome activity
- GN10113 Cepharanthine
- GC60688 Cereblon modulator 1 Cereblon modulator 1 (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue.
- GC35667 CFTR corrector 1 CFTR corrector 1 (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR).
- GC34532 CFTR corrector 2 CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933.
- GC14421 CFTRinh-172 CFTR inhibitor, highly potent and selective
- GC35668 CG-200745 CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects.
- GC13365 CGI-1746 A potent, selective BTK inhibitor
- GN10463 Chelerythrine
- GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL
- GC17985 Chenodeoxycholic Acid nuclear receptors(FXR) activator
- GC48595 Chenodeoxycholic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy.
-
GC16702
CHIR-99021 (CT99021)
A selective GSK3 inhibitor
- GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride)
- GN10518 Chitosamine hydrochloride
- GC60700 Chloroquine D5 Chloroquine D5 is deuterium labeled Chloroquine.
- GC10295 Chloroquine diphosphate Chloroquine diphosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
- GC45885 Chloroquine-d5 (phosphate) An internal standard for the quantification of chloroquine
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GC14216
Chlorpromazine HCl
dopamine receptor antagonist
- GC43265 Chromomycin A2 Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities.
- GC10132 Ciclopirox broad-spectrum antifungal agent
- GC13559 Cilengitide Integrin inhibitor for αvβ3 and αvβ5
- GC61520 Cilengitide TFA Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.
- GC18212 Cilofexor Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay).
- GC15890 Cilostazol A PDE3A inhibitor
- GN10189 Cinobufagin
- GC12226 Cisatracurium Besylate Neuromuscular-blocking drug
- GC14035 Citalopram hydrobromide 5-HT uptake inhibitor
- GC16754 Clarithromycin A macrolide antibiotic
- GC16581 Clasto-Lactacystin β-lactone A selective inhibitor of the 20S proteasome
- GC14892 Clemastine Fumarate Selective histamine H1 receptor antagonist
- GC64524 Clematichinenoside AR Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS).
- GC15810 Clinofibrate HMGCR inhibitor
- GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity.
- GC15219 Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase
- GC16804 Clotrimazole antifungal compound
-
GC13261
Colchicine
An inhibitor of microtubule polymerization
- GC16332 Colistin Sulfate Cationic polypeptide antibiotic
-
GC17519
Concanamycin A
V-type (vacuolar) H+-ATPase inhibitor
- GN10810 Cordycepin
- GN10015 Corosolic Acid
- GC32959 Corynoxine An indole alkaloid
- GC52477 Corynoxine (hydrochloride) An indole alkaloid
- GC32826 Corynoxine B Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer.
- GC14906 Crenolanib (CP-868596) Crenolanib (CP-868596) is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively.
- GC30360 Cresol (Cresol mixture of isomers)
-
GC12616
Crizotinib hydrochloride
inhibitor of the c-Met kinase and the NPM-ALK
- GN10501 Cryptotanshinone
- GN10535 Cucurbitacin B
- GN10526 Cucurbitacin E
- GC14787 Curcumin A yellow pigment with diverse biological activities
- GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
- GC14495 CX 546 AMPA receptor potentiator
- GC13037 CX-4945 (Silmitasertib) CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.
- GC11325 CX-4945 sodium salt CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.