Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Targets for Neuroscience
- 5-HT Receptor(549)
- AChR(62)
- AChE(114)
- Alzheimer(109)
- Amyloid β(157)
- BACE(5)
- CGRP (33)
- COX(306)
- DAPK(6)
- Dopamine Receptor(319)
- GABA Receptor(239)
- Gap Junction(23)
- GluR(121)
- Histamine(4)
- Histamine Receptor(241)
- mPEGS-1(5)
- Muscarinic Receptor(46)
- Neuroscience Peptides(94)
- Nicotinic Receptor(70)
- P2 Receptor(2)
- P2X7 receptor(5)
- SSRIs(8)
- Substance P/NK1 Receptor(22)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(139)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(60)
- iGluR(139)
- nAChR(66)
- Beta-secretase(26)
- CaMK(33)
- Dopamine Transporter(17)
- Monoamine Oxidase(84)
- Serotonin Transporter(57)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Products for Neuroscience
- Cat.No. Product Name Information
- GC12432 (+)-Anabasine hydrochloride neuronal nicotinic ACh receptor partial agonist
-
GN10745
(+)-Bicuculline
(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.
- GC34954 (+)-Borneol
- GN10605 (+)-Catechin hydrate
- GC34957 (+)-Cevimeline hydrochloride hemihydrate (+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
- GN10654 (+)-Corynoline
- GC45263 (+)-D-threo-PDMP (hydrochloride) (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP.
-
GC30933
(+)-Kavain
An Analytical Reference Standard
-
GC10736
(+)-Muscarine iodide
Muscarinic acetylcholine receptor agonist
- GC68210 (+)-Norfenfluramine
-
GC30848
(+)-PD 128907 hydrochloride
A potent D3 receptor agonist
- GC34959 (+)-Sparteine (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent.
- GC11062 (+)-Tubocurarine chloride nicotinic acetylcholine receptor antagonist
- GC12870 (+)-UH 232 maleate D2 antagonist
- GC11049 (+/-)-Sulfinpyrazone platelet COX inhibitor
- GC38677 (-)-α-Pinene (-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.
- GC45244 (-)-(α)-Kainic Acid (hydrate) A potent central nervous system stimulant for induction of seizures
- GC31084 (-)-(S)-B-973B
- GC10065 (-)-Bicuculline methiodide GABAA receptor antagonist
- GC16857 (-)-Bicuculline methobromide
- GC15636 (-)-Bicuculline methochloride
- GC40842 (-)-Catechin
- GC32957 (-)-Catechin gallate ((-)-Catechin 3-gallate) (-)-Catechin gallate ((-)-Catechin 3-gallate) is a minor constituent in green tea catechins. (-)-Catechin gallate ((-)-Catechin 3-gallate) inhibits the activity of COX-1 and COX-2 enzymes.
- GC34947 (-)-Corynoxidine (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa.
- GC17470 (-)-Cotinine α3/α6β2 nAChR activator
- GC18343 (-)-CP 55,940 (-)-CP 55,940 is a potent and non-selective cannabinoid (CB) receptor agonist with Ki values of 0.5 to 5 and 0.69 to 2.8 nM for CB1 and CB2 receptors, respectively.
- GC10603 (-)-epicatechin gallate major catechin in green tea
- GC14400 (-)-Huperzine A AChE inhibitor
- GC34949 (-)-Isocorypalmine An isoquinoline alkaloid and metabolite of L-THP with diverse biological activities
- GC45250 (-)-L-threo-PDMP (hydrochloride) (-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis.
- GC14157 (-)-Lobeline hydrochloride nicotinic receptor partial agonist
- GC48551 (-)-Physostigmine (salicylate) An alkaloid and cholinergic agent
- GC17877 (-)-Quinpirole hydrochloride dopamine D2 receptor agonist
- GC46248 (-)-Ropivacaine-d7 (hydrochloride) An internal standard for the quantification of (–)-ropivacaine
- GC30889 (-)-Securinine An alkaloid
- GC38489 (1α,1'S,4β)-Lanabecestat (1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat.
- GC16207 (1S,3R)-ACPD group I and II mGlu receptor agonist
- GC18622 (2'S)-Nicotine-1-oxide (2'S)-Nicotine-1-oxide is a metabolite of nicotine .
- GC11379 (2R,4R)-APDC group II metabotropic glutamate receptor agonist
- GC60000 (2S)-6-Prenylnaringenin (2S)-6-Prenylnaringenin is the most efficient compound in forebrain.
- GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
- GC52100 (Arg)9 (trifluoroacetate salt) A cationic cell-penetrating peptide
- GC66255 (E)-3,4,5-Trimethoxycinnamic acid (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy.
- GC49003 (E)-Ajoene A disulfide with diverse biological activities
- GC40286 (E,Z)-2-propyl-2-Pentenoic Acid (E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.
- GC17333 (R)-(+)-8-Hydroxy-DPAT hydrobromide 5-HT1A serotonin receptor agonist
-
GC69834
(R)-(+)-Dimethindene maleate
(R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with anti-histamine properties in pigs.
- GC41709 (R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group.
- GC41711 (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide N-Acyl ethanolamines have diverse biological actions that are strongly affected by the associated acyl group.
- GC11219 (R)-(+)-Tolterodine (R)-(+)-Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
- GC11809 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM.
- GC17722 (R)-3,4-DCPG AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors
- GC14124 (R)-3-Carboxy-4-hydroxyphenylglycine NMDA and AMPA/kainate receptor antagonist
- GC40594 (R)-AM1241 (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors).
- GC14111 (R)-baclofen GABA receptor agonist
- GC34986 (R)-Baclofen hydrochloride (R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist.
-
GC69805
(R)-Casopitant
(R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.
- GC41715 (R)-Cetirizine (hydrochloride) A selective histamine H1 receptor antagonist
- GC50258 (R)-Citalopram oxalate Enantiomer of escitalopram oxalate
- GC41718 (R)-KT109 (R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC67937 (R)-Mirtazapine
- GC68383 (R)-Preclamol
- GC34993 (R)-Rivastigmine D6 tartrate
- GC18238 (R)-γ-Valerolactone (R)-γ-Valerolactone ((R)-GVL) is an isomer of GVL, a prodrug to γ-hydroxyvaleric acid (GHV).
- GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron.
- GC16032 (R,S)-Anatabine Aβ inhibitor
- GC16139 (R,S)-Anatabine (tartrate) Aβ inhibitor
- GC52185 (R,S)-Anatabine-d4
- GC63632 (Rac)-Lorcaserin
- GC63382 (Rac)-Lorcaserin hydrochloride
- GC62745 (Rac)-PF-06256142 (Rac)-PF-06256142 is the less effective enantiomer of PF-06256142.
- GC60004 (rel)-Tranylcypromine D5 hydrochloride Tranylcypromine-d5 (SKF 385-d5) hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.
- GC10349 (RS)-(±)-Sulpiride (RS)-(±)-Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression.
- GC16542 (RS)-3,4-DCPG antagonist of AMPA receptors and agonist of mGluR8
- GC15342 (RS)-3,5-DHPG DHPG ((RS)-3,5-DHPG) is an amino acid that is a selective potent agonist for group I mGluR (mGluR 1 and mGluR 5) and has no effect on Group II and III mGluR.
- GC12985 (RS)-3-Hydroxyphenylglycine PI-linked metabotropic glutamate receptors agonist
- GC13288 (RS)-4-Carboxy-3-hydroxyphenylglycine broad spectrum EAA agonist/antagonist
- GC13773 (RS)-4-Carboxyphenylglycine broad spectrum EAA ligand
- GC11771 (RS)-APICA group II metabotropic glutamate receptor antagonist
- GC12279 (RS)-MCPG mGluR antagonist
- GC11997 (RS)-MCPG disodium salt group I/group II metabotropic glutamate receptor antagonist
- GC11433 (RS)-PPG group III metabotropic glutamate receptor agonist
- GC10704 (S)-(+)-α-Methylhistamine dihydrobromide H3 histamine receptor agonist
-
GC41727
(S)-(+)-3-Quinuclidinol
(S)-(+)-Quinuclidinol is a precursor in the synthesis of solifenacin.
-
GC14479
(S)-(+)-Dimethindene maleate
M2 muscarinic receptor antagonist
- GC13114 (S)-(+)-Ibuprofen COX inhibitor
- GC64804 (S)-(+)-Ibuprofen D3 (S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen.
- GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist
- GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.
- GC64735 (S)-(-)-Levamisole (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties.
- GC14639 (S)-3,4-DCPG mGlu8a agonist
- GC16858 (S)-3,5-DHPG group I mGlu receptor agonist
- GC11536 (S)-3-Carboxy-4-hydroxyphenylglycine group I metabotropic glutamate receptor antagonist and group II mGlu agonist
- GC16234 (S)-3-Hydroxyphenylglycine group I metabotropic glutamate receptors agonist
- GC45964 (S)-3-N-Cbz-amino-succinimide An anticonvulsant
- GC12012 (S)-4-Carboxy-3-hydroxyphenylglycine group I mGlu1a/1a receptor antagonist and mGluR2 agonist
- GC14176 (S)-4-Carboxyphenylglycine group I metabotropic glutamate receptor antagonist
- GC40595 (S)-AM1241 (S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors).
- GC63655 (S)-Amisulpride (S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist.
- GC46352 (S)-DO271 An inactive control for DO264