Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Targets for Neuroscience
- 5-HT Receptor(549)
- AChR(62)
- AChE(114)
- Alzheimer(109)
- Amyloid β(157)
- BACE(5)
- CGRP (33)
- COX(306)
- DAPK(6)
- Dopamine Receptor(319)
- GABA Receptor(239)
- Gap Junction(23)
- GluR(121)
- Histamine(4)
- Histamine Receptor(241)
- mPEGS-1(5)
- Muscarinic Receptor(46)
- Neuroscience Peptides(94)
- Nicotinic Receptor(70)
- P2 Receptor(2)
- P2X7 receptor(5)
- SSRIs(8)
- Substance P/NK1 Receptor(22)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(139)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(60)
- iGluR(139)
- nAChR(66)
- Beta-secretase(26)
- CaMK(33)
- Dopamine Transporter(17)
- Monoamine Oxidase(84)
- Serotonin Transporter(57)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Products for Neuroscience
- Cat.No. Product Name Information
- GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols
- GC14752 2,4-Dihydroxyphenylacetyl-L-asparagine glutamate receptors blocker
- GC49159 2-(1-Piperazinyl)pyrimidine An α2-AR antagonist and active metabolite of azapirones
- GC46505 2-(Isopentylamino)naphthalene-1,4-dione A vitamin K analog
- GC17308 2-3-Pyridinedicarboxylic acid
- GC49481 2-Aminotetralin A neuromodulatory agent
- GC14873 2-CMDO Dopamine D2-like receptor antagonist
- GC40473 2-hydroxy Lignoceric Acid 2-hydroxy Lignoceric acid is an α-hydroxy very long chain fatty acid that is normally present in the mammalian nervous system.
- GC11267 2-Hydroxysaclofen GABAB receptor antagonist
- GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist.
- GC11176 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist.
- GC49840 2-Methylbutyrylglycine A metabolite of isoleucine
- GC52170 2-Nitroamino-2-imidazoline
-
GC11001
2-Pyridylethylamine dihydrochloride
Histamine H1 receptor agonist
- GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor
- GC42087 21-desacetyl Deflazacort 21-desacetyl Deflazacort is the active glucocorticoid derived from the prodrug deflazacort.
- GC41210 22-HDHA 22-HDHA is an oxidation product of docosahexaenoic acid.
-
GC40571
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.
- GC41614 24-dehydro Cholesterol 24-dehydro Cholesterol is a molecule similar to cholesterol.
- GC46243 24-dehydro Cholesterol-d6 An internal standard for the quantification of 24-dehydro cholesterol
- GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
- GC31021 2614W94 2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate.
-
GC15856
3'-Fluorobenzylspiperone maleate
ligand for the D2 receptor
- GC15606 3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride dopamine uptake and transport inhibitor
- GC41480 3'-hydroxy Lidocaine 3'-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.
- GC42242 3'-sulfo Galactosylsphingosine (ammonium salt) 3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group.
- GC42201 3,3'-Diiodo-L-thyronine 3,3'-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3'-T2.
- GC33703 3,4,5-Trimethoxycinnamic acid 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals.
- GC14343 3,4-dihydro Naratriptan selective serotonin 5-HT1B agonist
- GC46557 3,4-Dihydroquinolin-2(1H)-one A building block
- GC49169 3,8’-Biapigenin A biflavonoid with diverse biological activities
- GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
- GC42198 3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt) An inactive metabolite of baclofen
- GC46583 3-Amino-2,6-Piperidinedione An active metabolite of (±)-thalidomide
- GC52129 3-Amino-5-hydroxybenzoic Acid
- GC42248 3-Aminopropylphosphonic Acid 3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).
- GC15569 3-AQC 5-HT3 antagonist
- GC11757 3-Bromocytisine α4β4, α4β2 and α7 nACh receptor agonist
- GC12641 3-CPMT dopamine uptake inhibitor
- GC42258 3-Cysteinylacetaminophen (trifluoroacetate salt) An acetaminophen-protein adduct
- GC60499 3-Hydroxy agomelatine 3-Hydroxy agomelatine is a metabolite of Agomelatine.
- GC68328 3-Hydroxy agomelatine-d3
- GC42274 3-hydroxy Darifenacin 3-hydroxy Darifenacin is a metabolite of darifenacin.
- GC41565 3-hydroxy Medetomidine 3-hydroxy Medetomidine is a metabolite of the α2-adrenergic receptor agonist medetomidine.
- GC18311 3-hydroxy Octanoic Acid 3-hydroxy Octanoic acid is a hydroxylated fatty acid that has been found in LPS from P.
- GC40487 3-hydroxy Undecanoic Acid 3-hydroxy Undecanoic acid is a hydroxylated fatty acid that has been found in S.
- GC52048 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) is a catecholamine compound that has an inhibitory effect on dihydropteridine reductase.
- GC45336 3-hydroxy-DL-Kynurenine 3-hydroxy-DL-Kynurenine, ametabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders.
- GC42294 3-Iodothyronamine (hydrochloride) 3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine.
- GC11223 3-MATIDA mGlu1 receptor antagonist
- GC49869 3-Methoxytyrosine An active metabolite of L-DOPA
- GC12506 3-Methyl-GABA GABA aminotransferase activator
- GC49149 3-Methylglutaconic Acid A branched-chain organic acid
- GC42307 3-O-methyl-L-DOPA (hydrate) 3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.
- GC60505 3-O-Methyldopa 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT).
- GC60506 3-O-Methyldopa D3 3-O-Methyldopa D3 (3-Methoxy-L-tyrosine-d3) is deuterium labeled 3-O-Methyldopa.
-
GC10484
3-pyr-Cytisine
α4β2 receptors agonist
- GC52391 306-O12B-3 An ionizable cationic lipidoid
- GC18817 3β-hydroxy-5-Cholestenoic Acid 3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1.
- GC49367 4’-hydroxy Atomoxetine Glucuronide (hydrate) A metabolite of atomoxetine
- GC49252 4’-hydroxy Trazodone A metabolite of trazodone
- GC40768 4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid 4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5.
- GC45340 4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic Acid
- GC62799 4,4-Diphenylbutylamine hydrochloride 4,4-Diphenylbutylamine shows affinity for the 5-HT2A and H1 receptors with Kis of 2589 and 1670 nM, respectively.
- GC49752 4,5-Desisopropylidene Topiramate An inactive metabolite of topiramate
- GC30952 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid-β (1-40) with a KD of 1.7 nM.
- GC31208 4-(6-Bromo-2-benzothiazolyl)benzenamine 4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.
- GC40045 4-(Dimethylamino)-1-methylpyridinium (iodide) 4-(Dimethylamino)-1-methylpyridinium is a monoquaternary pyridinium salt with anticholinesterase and antiproliferative activities.
- GC33504 4-Acetamidobutanoic acid (N-acetyl GABA) 4-Acetamidobutanoic acid (N-acetyl GABA) (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities.
- GC15383 4-Acetyl-1,1-dimethylpiperazinium iodide nicotinic agonist
- GC42338 4-Aminobenzoic Acid hydrazide 4-Aminobenzoic Acid hydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 μM.
- GC49657 4-chloro Trazodone isomer (hydrochloride) An isomer of trazodone
- GC13348 4-DAMP M3 cholinergic receptor antagonist
- GC42373 4-epi Minocycline 4-epi Minocycline is the main degradation product of and a potential impurity in commercial preparations of minocycline.
- GC48824 4-hydroxy Estrone A metabolite of estrone
-
GC42411
4-hydroxy Nonenal Alkyne
4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.
- GC40879 4-hydroxy Solifenacin N-oxide 4-hydroxy Solifenacin N-oxide is an N-oxide form of 4-hydroxy solifenacin, the major metabolite of solifenacin .
- GC42417 4-hydroxy-3-Methoxyphenylglycol (piperazine salt) 4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate.
- GC60519 4-Hydroxyderricin 4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM.
- GC63628 4-Hydroxymidazolam
- GC39307 4-Methylamino antipyrine 4-Methylamino antipyrine is an active metabolite of Metamizole.
- GC60523 4-Methylamino antipyrine hydrochloride An active metabolite of metamizole
- GC11606 4-Methylbenzylidene camphor ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.
- GC12737 4-Methylhistamine dihydrochloride H4 receptor agonist
- GC42443 4-Methylumbelliferyl 6-thio-Palmitate-β-D-Glucopyranoside 4-Methylumbelliferyl 6-thio-Palmitate-β-D-Glucopyranoside is a fluorogenic substrate for palmitoyl-protein thioesterase (PPT).
- GC40510 4-Methylumbelliferyl-α-D-Galactopyranoside 4-Methylumbelliferyl-α-D-galactopyranoside (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase.
- GC42447 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases.
- GC49244 4-oxo Isotretinoin An active metabolite of isotretinoin
- GC14311 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride dopamine release inhibitor
- GC46675 4-Phenyl-2-pyrrolidinone A precursor and synthetic intermediate
- GC16040 4F 4PP oxalate 5-HT2A antagonist
- GC40053 5α,6α-epoxy Cholestanol An oxysterol and a metabolite of cholesterol produced by oxidation
- GC46715 5α,6β-Dihydroxycholestanol-d7 An internal standard for the quantification of 5α,6β-dihydroxycholestanol
- GC48843 5α-Androst-16-en-3α-ol A pheromone with diverse biological activities
- GC49540 5α-Androst-2-ene-17-one A steroid and synthetic intermediate
- GC18582 5'-hydroxy Meloxicam A metabolite of meloxicam
- GC60527 5,7-Dimethoxyluteolin 5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC50 of 3.417 μM.
- GC14814 5-Carboxamidotryptamine maleate 5-HT1 agonist
- GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.
- GC60028 5-HT1A modulator 2 hydrochloride 5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT, is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding.