Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC44464 NSC 109555 An inhibitor of Chk2 NSC 109555 Chemical Structure
  3. GC13448 NSC 109555 ditosylate Chk2 inhibitor,ATP-competitive NSC 109555 ditosylate Chemical Structure
  4. GC46190 NSC 15520 An inhibitor of RPA70 dsDNA binding NSC 15520 Chemical Structure
  5. GC10069 NSC 23766 trihydrochloride Selective inhibitor of Rac1-GEF interaction. NSC 23766 trihydrochloride Chemical Structure
  6. GC12886 NSC 625987 Cyclin-dependent kinase (cdk) 4 inhibitor NSC 625987 Chemical Structure
  7. GC11634 NSC 693868 CDKs and GSK-3 inhibitor NSC 693868 Chemical Structure
  8. GC49412 NSC 756093 An inhibitor of the GBP1-Pim-1 protein-protein interaction NSC 756093 Chemical Structure
  9. GC15963 Nu 6027 ATR/CDK inhibitor, potent and selective Nu 6027 Chemical Structure
  10. GC18278 NU 6102 Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. NU 6102 Chemical Structure
  11. GC34692 NU6140 A Cdk2 inhibitor NU6140 Chemical Structure
  12. GC16959 NVP-LCQ195 NVP-LCQ195 Chemical Structure
  13. GC32830 NVS-PAK1-1 An allosteric inhibitor of PAK1 NVS-PAK1-1 Chemical Structure
  14. GC44478 NVS-PAK1-C NVS-PAK1-C is a negative control for the allosteric PAK1 inhibitor NVS-PAK1-1. NVS-PAK1-C Chemical Structure
  15. GC61870 NY2267 NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation. NY2267 Chemical Structure
  16. GC49186 O-Demethyl Apremilast An active metabolite of apremilast O-Demethyl Apremilast Chemical Structure
  17. GC18727 O-methyl Sterigmatocystin O-methyl Sterigmatocystin (OMST) is a xanthone found in several fungal species including A. O-methyl Sterigmatocystin Chemical Structure
  18. GC47814 Ochratoxin A-13C20 An internal standard for the quantification of ochratoxin A Ochratoxin A-13C20 Chemical Structure
  19. GC44495 OH-C-Chol OH-C-Chol is a cationic cholesterol derivative. OH-C-Chol Chemical Structure
  20. GC45534 OH-Chol   OH-Chol Chemical Structure
  21. GC16520 Olomoucine cdk inhibitor Olomoucine Chemical Structure
  22. GC48652 Olomoucine II A CDK inhibitor Olomoucine II Chemical Structure
  23. GC32551 Ombrabulin (AC-7700) Ombrabulin (AC-7700) (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. Ombrabulin (AC-7700) Chemical Structure
  24. GC34022 Ombrabulin hydrochloride (AVE8062) Ombrabulin hydrochloride (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. Ombrabulin hydrochloride (AVE8062) Chemical Structure
  25. GC62174 ON1231320 ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 ?M. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity. ON1231320 Chemical Structure
  26. GC15607 ON123300 multi-targeted kinase inhibitor,inhibits CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn ON123300 Chemical Structure
  27. GN10732 Oroxin B Oroxin B Chemical Structure
  28. GC64626 Oryzalin Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro. Oryzalin Chemical Structure
  29. GC33163 OSIP-486823 (OSIP 486823) OSIP-486823 (OSIP 486823) is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules. OSIP-486823 (OSIP 486823) Chemical Structure
  30. GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor OXA 06 dihydrochloride Chemical Structure
  31. GC65897 OXi8007 OXi8007 is a water-soluble phosphate prodrug of OXi8006, a tubulin-binding compound. OXi8007 Chemical Structure
  32. GC45538 Oxychlororaphine   Oxychlororaphine Chemical Structure
  33. GA23337 Oxythiamine . HCl Thiamine antagonist and inhibitor of saccharomyces cerevisiae transketolase. RaÏs et al. indicated that oxythiamine inhibits the growth of Ehrlich's tumor cells. Oxythiamine . HCl Chemical Structure
  34. GC40256 p-APMSF (hydrochloride) p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. p-APMSF (hydrochloride) Chemical Structure
  35. GC50599 P110 Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable P110 Chemical Structure
  36. GC12511 Paclitaxel (Taxol)

    A potent mitotic inhibitor

     Paclitaxel (Taxol) Chemical Structure
  37. GC49404 Paclitaxel C A taxoid and an inhibitor of microtubule depolymerization Paclitaxel C Chemical Structure
  38. GC45758 Paclitaxel octadecanedioate A prodrug form of paclitaxel Paclitaxel octadecanedioate Chemical Structure
  39. GC47853 Paclitaxel-d5 An internal standard for the quantification of paclitaxel Paclitaxel-d5 Chemical Structure
  40. GC33421 PAK-IN-1 PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively. PAK-IN-1 Chemical Structure
  41. GC46196 Pal-KTTKS (acetate) A lipidated pentapeptide Pal-KTTKS (acetate) Chemical Structure
  42. GC15421 Palbociclib (PD0332991) Isethionate Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib (PD0332991) Isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. Palbociclib (PD0332991) Isethionate Chemical Structure
  43. GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid MaxSpec® Standard Chemical Structure
  44. GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Palmitic Acid-d9 MaxSpec® Standard Chemical Structure
  45. GC49014 Palmitoyl Tetrapeptide-7 (acetate) A cosmeceutical peptide Palmitoyl Tetrapeptide-7 (acetate) Chemical Structure
  46. GC15940 PalMitoyl Tripeptide-1 A form of GHK containing palmitic acid PalMitoyl Tripeptide-1 Chemical Structure
  47. GC49702 Papain Inhibitor (trifluoroacetate salt) A peptide inhibitor of papain Papain Inhibitor (trifluoroacetate salt) Chemical Structure
  48. GC12788 Paprotrain

    mitotic kinesin-like protein 2 (MKLP-2) inhibitor

     Paprotrain Chemical Structure
  49. GC45944 para-amino-Blebbistatin A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility para-amino-Blebbistatin Chemical Structure
  50. GC47923 Paraxanthine-d6 An internal standard for the quantification of paraxanthine Paraxanthine-d6 Chemical Structure
  51. GC32134 Parbendazole (SKF 29044) Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530nM, and exhibits a broad-spectrum anthelmintic activity. Parbendazole (SKF 29044) Chemical Structure
  52. GC40085 Pazopanib-d6 Pazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib-d6 Chemical Structure
  53. GC33002 PBOX 6 PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent. PBOX 6 Chemical Structure
  54. GC15173 PD 0332991 (Palbociclib) PD 0332991 (Palbociclib) (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. PD 0332991 (Palbociclib) Chemical Structure
  55. GC17935 PD 0332991 (Palbociclib) HCl Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. PD 0332991 (Palbociclib) HCl has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. PD 0332991 (Palbociclib) HCl Chemical Structure
  56. GC50045 PD 166285 dihydrochloride PD 166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD 166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1. PD 166285 dihydrochloride Chemical Structure
  57. GC44584 PD 168368 PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors (Kis = 15-45 nM for rat and human receptors expressed in various cell lines). PD 168368 Chemical Structure
  58. GC38216 PD 407824 PD 407824 Chemical Structure
  59. GC32853 PD0166285 PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1. PD0166285 Chemical Structure
  60. GC30801 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. PE859 Chemical Structure
  61. GC40622 Penicillide Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. Penicillide Chemical Structure
  62. GC33901 Pentanoic acid Pentanoic acid Chemical Structure
  63. GC50439 Peptide5 Connexin43 mimetic peptide Peptide5 Chemical Structure
  64. GC69687 PERK-IN-2

    PERK-IN-2 is a highly efficient PERK inhibitor with an IC50 value of 0.2 nM.

     PERK-IN-2 Chemical Structure
  65. GC64866 PERK-IN-5 PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model. PERK-IN-5 Chemical Structure
  66. GC69688 PERK-IN-6

    PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM.

     PERK-IN-6 Chemical Structure
  67. GC50314 PF 3758309 dihydrochloride Potent PAK4 inhibitor; orally available PF 3758309 dihydrochloride Chemical Structure
  68. GC11944 PF 4800567 hydrochloride casein kinase 1ε inhibitor PF 4800567 hydrochloride Chemical Structure
  69. GC33136 PF-06380101 PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs. PF-06380101 Chemical Structure
  70. GC63740 PF-06380101-d8 PF-06380101 d8 (Aur0101 d8) is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101-d8 Chemical Structure
  71. GC34297 PF-2771 PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent. PF-2771 Chemical Structure
  72. GC17214 PF-3758309 An inhibitor of PAK4 PF-3758309 Chemical Structure
  73. GC14234 PF-477736 Chk1 inhibitor PF-477736 Chemical Structure
  74. GC11324 PHA-767491 A potent Cdc7 kinase inhibitor PHA-767491 Chemical Structure
  75. GC15588 PHA-848125 PHA-848125 (PHA-848125) is a potent, ATP-competitive and dual inhibitor of CDK and Tropomyosin receptor kinase (TRK), with IC50s of 45, 150, 160, 363, 398 nM and 53 nM for cyclin A/CDK2, cyclin H/CDK7, cyclin D1/CDK4, cyclin E/CDK2, cyclin B/CDK1 and TRKA, respectively. PHA-848125 Chemical Structure
  76. GC44618 Phalloidin-AMCA Conjugate Phalloidin-AMCA conjugate is a blue fluorophore that specifically labels filamentous actin (F-actin). Phalloidin-AMCA Conjugate Chemical Structure
  77. GC44620 Phalloidin-Tetramethylrhodamine Conjugate Phalloidin-retramethylrhodamine conjugate is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. Phalloidin-Tetramethylrhodamine Conjugate Chemical Structure
  78. GC40265 Pheleuin Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde. Pheleuin Chemical Structure
  79. GC32743 Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate) Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate) is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively. Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate) Chemical Structure
  80. GC49015 Phenethyl isothiocyanate An isothiocyanate with anticancer activity Phenethyl isothiocyanate Chemical Structure
  81. GC49128 Phenylbutazone-d9 An internal standard for the quantification of phenylbutazone Phenylbutazone-d9 Chemical Structure
  82. GC15514 Phomopsin A cyclic hexapeptide mycotoxin that binds β-tubulin Phomopsin A Chemical Structure
  83. GC48394 Phomopsinamine An inhibitor of microtubule polymerization Phomopsinamine Chemical Structure
  84. GC44633 Phosphatidylserines (bovine) Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. Phosphatidylserines (bovine) Chemical Structure
  85. GC18522 Phosphatidylserines (sodium salt) Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. Phosphatidylserines (sodium salt) Chemical Structure
  86. GC38456 Pironetin An inhibitor of microtubule assembly Pironetin Chemical Structure
  87. GC44652 PK7242 (maleate) The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. PK7242 (maleate) Chemical Structure
  88. GC45846 PKUMDL-LC-101-D04 An allosteric activator of GPX4 PKUMDL-LC-101-D04 Chemical Structure
  89. GC10235 Plinabulin (NPI-2358) Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. Plinabulin (NPI-2358) Chemical Structure
  90. GC65189 PLK4-IN-1 PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM. PLK4-IN-1 Chemical Structure
  91. GC69718 Plogosertib

    Plogosertib (CYC140) is a selective, potent, orally active ATP-competitive PLK1 inhibitor (IC50: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity and can be used for research on various tumors including esophageal cancer, gastric cancer, leukemia, non-small cell lung cancer, ovarian cancer and squamous cell carcinoma.

     Plogosertib Chemical Structure
  92. GC46019 Pluviatolide A lignan Pluviatolide Chemical Structure
  93. GC17977 PM 102 heparin antagonist PM 102 Chemical Structure
  94. GC10521 Podophyllotoxin A lignan with diverse biological activities Podophyllotoxin Chemical Structure
  95. GC49077 Podophyllotoxin-d6 An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin Podophyllotoxin-d6 Chemical Structure
  96. GC64705 Podophyllotoxone Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization. Podophyllotoxone Chemical Structure
  97. GC14735 Poloxime polo-like kinase 1 （PLK) analogue Poloxime Chemical Structure
  98. GC13543 Poloxin An inhibitor of the Plk1 polo-box domain Poloxin Chemical Structure
  99. GC45680 Prodan A solvatochromic fluorescent probe Prodan Chemical Structure
  100. GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole Propiconazole-d7 Chemical Structure
  101. GC18353 Prostaglandin A2 A naturally occurring prostaglandin with antiviral/antitumor activity Prostaglandin A2 Chemical Structure

Items 701 to 800 of 1035 total

per page
  2. 6
  3. 7
  4. 8
  5. 9
  6. 10

Set Descending Direction