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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide)) Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromide (RU-19110 (hydrobromide)) Chemical Structure
  3. GC62328 HBV-IN-4 HBV-IN-4, a phthalazinone derivative, is a potent and orally active HBV DNA replication inhibitor with an IC50 of 14 nM. HBV-IN-4 Chemical Structure
  4. GC36211 HBX 19818 HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM. HBX 19818 Chemical Structure
  5. GC19190 HDAC-IN-4 HDAC-IN-4 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-4 has no activity against HDAC class II. HDAC-IN-4 has antitumor activity. HDAC-IN-4 Chemical Structure
  6. GC66052 HDAC-IN-40 HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects. HDAC-IN-40 Chemical Structure
  7. GC33395 HDAC-IN-5 HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. HDAC-IN-5 Chemical Structure
  8. GC68010 HDAC3-IN-T247 HDAC3-IN-T247 Chemical Structure
  9. GC41085 HDAC6 Inhibitor HDAC6 Inhibitor is a potent and selective HDAC6 inhibitor (IC50=36 nM). HDAC6 Inhibitor weakly inhibits other HDAC isoforms. HDAC6 Inhibitor inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM. HDAC6 Inhibitor Chemical Structure
  10. GC33317 HDAC6-IN-1 HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. HDAC6-IN-1 Chemical Structure
  11. GC19189 HDAC8-IN-1 HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM. HDAC8-IN-1 Chemical Structure
  12. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 Chemical Structure
  13. GC39279 hDHODH-IN-1 hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 Chemical Structure
  14. GC48388 Heliquinomycin A bacterial metabolite with diverse biological activities Heliquinomycin Chemical Structure
  15. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  16. GC40103 Herboxidiene Herboxidiene, as a potent antitumor agent, can target the SF3B subunit of the spliceosome. Herboxidiene also induces both G1 and G2/M cell cycle arrest in a human normal fibroblast cell line WI-38. Herboxidiene Chemical Structure
  17. GC12201 HI TOPK 032

    T-LAK-cell-originated protein kinase (TOPK) inhibitor

     HI TOPK 032 Chemical Structure
  18. GC11302 Hinokitiol A tropolone with diverse biological activities Hinokitiol Chemical Structure
  19. GC12334 HNHA HDAC inhibitor HNHA Chemical Structure
  20. GC11574 HPOB HDAC6 inhibitor, potent and selective HPOB Chemical Structure
  21. GC63854 HQ461 HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. HQ461 Chemical Structure
  22. GC62572 hSMG-1 inhibitor 11e hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM). hSMG-1 inhibitor 11e Chemical Structure
  23. GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer. hSMG-1 inhibitor 11j Chemical Structure
  24. GC16843 Hydroxyurea DNA synthesis inhibitor Hydroxyurea Chemical Structure
  25. GC49694 Hygromycin A An antibiotic Hygromycin A Chemical Structure
  26. GC48445 Hygromycin B (hydrate)

    An aminoglycoside antibiotic

     Hygromycin B (hydrate) Chemical Structure
  27. GC49267 Hygromycin B-d4

    An internal standard for the quantification of hygromycin

     Hygromycin B-d4 Chemical Structure
  28. GC14503 IC261 CK1 inhibitor IC261 Chemical Structure
  29. GC14969 Idarubicin HCl Idarubicin HCl is an anthracycline antileukemic drug. Idarubicin HCl Chemical Structure
  30. GC16003 Ifosfamide Cytostatic agent Ifosfamide Chemical Structure
  31. GC60929 Ilaprazole sodium Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium Chemical Structure
  32. GC41340 Illudin M Illudin M is a cytotoxic sesquiterpene from the fungus O. Illudin M Chemical Structure
  33. GC18100 Illudin S potent antitumor sesquiterpene Illudin S Chemical Structure
  34. GC62137 IMT1 IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 Chemical Structure
  35. GC65939 Indimitecan Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. Indimitecan Chemical Structure
  36. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid Chemical Structure
  37. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate Chemical Structure
  38. GC52513 Indolimine-214 A genotoxic gut microbiota metabolite Indolimine-214 Chemical Structure
  39. GC33205 Indotecan (LMP-400) Indotecan (LMP-400) (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan (LMP-400) Chemical Structure
  40. GC38385 INO-1001 INO-1001 Chemical Structure
  41. GC33165 Intoplicine Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. Intoplicine Chemical Structure
  42. GC63354 Intoplicine dimesylate Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. Intoplicine dimesylate Chemical Structure
  43. GC63023 Ipivivint Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM). Ipivivint Chemical Structure
  44. GC52175 IQA IQA Chemical Structure
  45. GC63513 IRE1α kinase-IN-1 IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 Chemical Structure
  46. GC64232 IRE1α kinase-IN-2 IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines. IRE1α kinase-IN-2 Chemical Structure
  47. GC11473 Irinotecan Topoisomerase I inhibitor Irinotecan Chemical Structure
  48. GC11048 Irinotecan HCl Trihydrate Irinotecan HCl Trihydrate ((+)-Irinotecan HCl Trihydrate) is a topoisomerase I inhibitor with antitumor activity. Irinotecan HCl Trihydrate Chemical Structure
  49. GC36329 Irinotecan hydrochloride Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. Irinotecan hydrochloride Chemical Structure
  50. GC30554 Isocytosine Isocytosine is a non-natural nucleobase and an isomer of cytosine. Isocytosine Chemical Structure
  51. GC33662 Isoguanine An isomer of guanine Isoguanine Chemical Structure
  52. GC39140 Isopimpinellin Isopimpinellin, an orally active compound isolated from the roots of Pimpinella saxifrage. Isopimpinellin Chemical Structure
  53. GC10834 Isoxanthopterin

    interferes with RNA and DNA synthesis

     Isoxanthopterin Chemical Structure
  54. GC14597 ITSA-1 (ITSA1) ITSA-1 (ITSA1) is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation. ITSA-1 (ITSA1) Chemical Structure
  55. GC14797 IU1 A deubiquitinating enzyme inhibitor IU1 Chemical Structure
  56. GC63027 IU1-248 IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83?μM. IU1-248 Chemical Structure
  57. GC64956 IU1-47 IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 Chemical Structure
  58. GC63460 IV-361 IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1). IV-361 Chemical Structure
  59. GC16454 IWP-2 IWP-2 is a inhibitor of the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 is also an ATP-competitive inhibitor of CK1δ, with an IC50 value of 40 nM. IWP-2 Chemical Structure
  60. GC63785 IXA4 IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 Chemical Structure
  61. GC34629 J22352 J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1. J22352 Chemical Structure
  62. GC64959 JAK/HDAC-IN-1 JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively. JAK/HDAC-IN-1 Chemical Structure
  63. GC36367 JH-RE-06 JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy. JH-RE-06 Chemical Structure
  64. GC65471 JH-XI-10-02 JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 Chemical Structure
  65. GC65577 JH-XVI-178 JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties. JH-XVI-178 Chemical Structure
  66. GC12612 JNJ-7706621 A dual inhibitor of CDKs and Aurora kinases JNJ-7706621 Chemical Structure
  67. GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. JS-K Chemical Structure
  68. GC34204 JSH-150 JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM. JSH-150 Chemical Structure
  69. GC50117 JTE 607 dihydrochloride JTE 607 dihydrochloride, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE 607 dihydrochloride Chemical Structure
  70. GC13978 JW 74 inhibitor of the catalytic PARP domain of TNKS1/2 JW 74 Chemical Structure
  71. GC34195 K-756 K-756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 with IC50s of 31 and 36 nM, respectively. K-756 Chemical Structure
  72. GC41384 K-TMZ K-TMZ is a DNA alkylating agent. K-TMZ Chemical Structure
  73. GC14230 K03861 K03861 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. K03861 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins. K03861 Chemical Structure
  74. GC47521 K22 An antiviral agent K22 Chemical Structure
  75. GC34144 Karenitecin (Cositecan) Karenitecin (Cositecan) (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity. Karenitecin (Cositecan) Chemical Structure
  76. GC62392 KB-0742 dihydrochloride KB-0742 dihydrochloride is a potent, selective and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. KB-0742 dihydrochloride is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 dihydrochloride has potent anti-tumor activity. KB-0742 dihydrochloride Chemical Structure
  77. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone Chemical Structure
  78. GC11774 KH CB19 inhibitor of CLK1 and CLK4, potent and selective KH CB19 Chemical Structure
  79. GC63943 KH-CB20 KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 Chemical Structure
  80. GC64238 KIRA-7 KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 Chemical Structure
  81. GC19212 KIRA6 KIRA6 allosterically inhibits IRE1α RNase kinase activity with an IC50 of 0.6 uM. KIRA6 Chemical Structure
  82. GC31879 Kira8

    Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

     Kira8 Chemical Structure
  83. GC65907 KSQ-4279 KSQ-4279 (USP1-IN-1, Formula I) is a USP1 and PARP inhibitor (extracted from patent WO2021163530). KSQ-4279 Chemical Structure
  84. GC25552 KT-531 KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms. KT-531 Chemical Structure
  85. GC33404 KU 59403 KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively. KU 59403 Chemical Structure
  86. GC14346 KU-0060648 Dual DNA-PK/PI3-K inhibitor, ATP-competitive KU-0060648 Chemical Structure
  87. GC12054 KU-60019 ATM kinase inhibitor,potent and selective KU-60019 Chemical Structure
  88. GC50532 KuWal151 Potent and selective CLK inhibitor KuWal151 Chemical Structure
  89. GC15743 L-755,507 β3 adrenergic receptor agonist L-755,507 Chemical Structure
  90. GC66622 L-Guanosine L-Guanosine is the L-configuration of Guanosine . Guanosine is a purine nucleoside with anti-herpesvirus activity. L-Guanosine Chemical Structure
  91. GC49381 L-Leucine-d10 An internal standard for the quantification of L-leucine L-Leucine-d10 Chemical Structure
  92. GC49368 L-Methionine-d3 An internal standard for the quantification of L-methionine L-Methionine-d3 Chemical Structure
  93. GC49384 L-Proline-d3 An internal standard for the quantification of L-proline L-Proline-d3 Chemical Structure
  94. GC12131 L189 inhibitor of human DNA ligases I, III and IV L189 Chemical Structure
  95. GC18186 L67 L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 uM for human DNA ligase I and human ligase IIIβ). L67 Chemical Structure
  96. GC67785 L82 L82 Chemical Structure
  97. GC68436 L82-G17 L82-G17 Chemical Structure
  98. GC39632 Laflunimus Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus Chemical Structure
  99. GC62460 LCAHA LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a. LCAHA Chemical Structure
  100. GC17067 LDC000067 CDK9 inhibitor, novel and highly specific LDC000067 Chemical Structure
  101. GC19219 LDC4297 LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. LDC4297 Chemical Structure

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