Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC66446 LDC4297 hydrochloride LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection. LDC4297 hydrochloride Chemical Structure
  3. GC10510 LDN 57444 An inhibitor of UCH-L1 LDN 57444 Chemical Structure
  4. GC60981 LDN-91946 LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM. LDN-91946 Chemical Structure
  5. GC10842 LEE011 LEE011 (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 Chemical Structure
  6. GC15922 LEE011 hydrochloride LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 hydrochloride Chemical Structure
  7. GC15377 LEE011 succinate LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 succinate Chemical Structure
  8. GC17904 Leflunomide AHR agonist,immunosuppressive agent Leflunomide Chemical Structure
  9. GC47552 Leflunomide-d4 An internal standard for the quantification of leflunomide Leflunomide-d4 Chemical Structure
  10. GC46166 Leoidin A depsidone Leoidin Chemical Structure
  11. GC34163 Lerociclib (G1T38) Lerociclib (G1T38) (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Lerociclib (G1T38) Chemical Structure
  12. GC34100 Lerociclib dihydrochloride (G1T38 dihydrochloride) Lerociclib dihydrochloride (G1T38 dihydrochloride) (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Lerociclib dihydrochloride (G1T38 dihydrochloride) Chemical Structure
  13. GC16203 Leucovorin Calcium Leucovorin Calcium (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Leucovorin Calcium Chemical Structure
  14. GC16680 Levoleucovorin Calcium Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium, possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil cytotoxicity against cancer. Levoleucovorin Calcium Chemical Structure
  15. GC11558 Levomefolate calcium A biologically active form of folic acid Levomefolate calcium Chemical Structure
  16. GC17466 LH846 Casein kinases inhibitor LH846 Chemical Structure
  17. GC15511 LIMKi 3 LIMKi 3 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. LIMKi 3 Chemical Structure
  18. GC33389 LMP744 (MJ-III65) LMP744 (MJ-III65) (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. LMP744 (MJ-III65) Chemical Structure
  19. GC33202 LMP744 hydrochloride (MJ-III65 hydrochloride) LMP744 hydrochloride (MJ-III65 hydrochloride) (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. LMP744 hydrochloride (MJ-III65 hydrochloride) Chemical Structure
  20. GC66659 LNA-A(Bz) amidite LNA-A(Bz) amidite can be used for synthesis of ASOs (antisense oligonucleotides). LNA-A(Bz) amidite Chemical Structure
  21. GC18404 Lometrexol Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol Chemical Structure
  22. GC66387 Lometrexol disodium Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. Lometrexol disodium Chemical Structure
  23. GC39820 Lometrexol hydrate A GART inhibitor Lometrexol hydrate Chemical Structure
  24. GC17865 Lomustine Antineoplastic drug Lomustine Chemical Structure
  25. GC34650 Longdaysin

    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of? 5.6 ?M, 8.8 ?M, 29 ?M, and 52 ?M, respectively.

     Longdaysin Chemical Structure
  26. GC36486 LSN 3213128 LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity. LSN 3213128 Chemical Structure
  27. GC61008 LSN3106729 hydrochloride LSN3106729 hydrochloride Chemical Structure
  28. GC19227 LTURM34

    LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

     LTURM34 Chemical Structure
  29. GC15612 Luotonin A binds to and stabilizes the topoisomerase I-DNA binary complex Luotonin A Chemical Structure
  30. GC15336 Luotonin F stabilizing the DNA topoisomerase I-DNA complex Luotonin F Chemical Structure
  31. GC63050 Lurbinectedin D3 Lurbinectedin D3 Chemical Structure
  32. GC33322 LY 254155 LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively. LY 254155 Chemical Structure
  33. GC15485 LY 294002 LY294002, a well-known PI3K signaling pathway inhibitor, is the first synthetic PI3Kα, δ and β inhibitor with IC50 of 500nM, 570nM and 970nM, respectively. LY 294002 Chemical Structure
  34. GC17522 LY2334737 Anticancer agent LY2334737 Chemical Structure
  35. GC15741 LY2603618 LY2603618 (LY2603618) is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM. LY2603618 Chemical Structure
  36. GC15663 LY2606368 LY2606368 (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. LY2606368 inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). LY2606368 causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. LY2606368 shows potent anti-tumor activity. LY2606368 Chemical Structure
  37. GC16822 LY2835219 LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively. LY2835219 Chemical Structure
  38. GC11823 LY2835219 free base A dual inhibitor of Cdk4 and Cdk6 LY2835219 free base Chemical Structure
  39. GC11971 LY2857785 CDK9 inhibitor LY2857785 Chemical Structure
  40. GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414 potently inhibits mTORC1/2 at low nanomolar concentrations. LY3023414 Chemical Structure
  41. GC33373 LY309887 LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity. LY309887 Chemical Structure
  42. GC25593 LY3143921 hydrate LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor. LY3143921 hydrate Chemical Structure
  43. GC19233 LY3177833 LY3177833 is an CDC7 and pMCM2 inhibitor extracted from patent US 20140275131and patent WO 2014143601 A1 compound example 4; has IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 Chemical Structure
  44. GC25594 LY3405105 LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity. LY3405105 Chemical Structure
  45. GC19238 Madrasin Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin Chemical Structure
  46. GC60234 Maleic hydrazide Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins. Maleic hydrazide Chemical Structure
  47. GC36549 Mauritianin A flavonoid glycoside and DNA topoisomerase I inhibitor Mauritianin Chemical Structure
  48. GC33411 MB-7133 MB-7133 Chemical Structure
  49. GC32970 MBQ-167 MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively. MBQ-167 Chemical Structure
  50. GC65079 MC-DOXHZN hydrochloride MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN hydrochloride Chemical Structure
  51. GC13419 ME0328 PARP inhibitor,potent and selective ME0328 Chemical Structure
  52. GC12393 Melphalan DNA alkylating agent Melphalan Chemical Structure
  53. GC61844 Merbarone Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent. Merbarone Chemical Structure
  54. GC13704 Mercaptopurine (6-MP) Mercaptopurine (6-MP) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug. Mercaptopurine (6-MP) Chemical Structure
  55. GC38201 Metarrestin Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models. Metarrestin Chemical Structure
  56. GC10405 Methotrexate

    Methotrexate(MTX) is an antifolate antimetabolite that effectively inhibits dihydrofolate reductase (DHFR) activity with an IC50 of approximately 7nM.

     Methotrexate Chemical Structure
  57. GC61047 Methotrexate disodium Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium Chemical Structure
  58. GC36589 Methotrexate metabolite Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate metabolite Chemical Structure
  59. GC36598 Methylnitronitrosoguanidine(wetted with ca. 50% Water) Methylnitronitrosoguanidine(wetted with ca. 50% Water) (MNNG) is an alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine(wetted with ca. 50% Water) Chemical Structure
  60. GC11222 Methylthioadenosine Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. Methylthioadenosine Chemical Structure
  61. GC61058 Metoprine Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine Chemical Structure
  62. GC34670 MF-094 MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy. MF-094 Chemical Structure
  63. GC11949 MI-192 inhibitor of histone deacetylases (HDACs) MI-192 Chemical Structure
  64. GC52165 Minosaminomycin Minosaminomycin Chemical Structure
  65. GC13491 Mirin Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Mirin Chemical Structure
  66. GC32886 Miriplatin (SM-11355) Miriplatin (SM-11355) (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents. Miriplatin (SM-11355) Chemical Structure
  67. GC36615 Miriplatin hydrate Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents. Miriplatin hydrate Chemical Structure
  68. GC15060 Mithramycin A A DNA-binding antitumor antibiotic Mithramycin A Chemical Structure
  69. GC44200 Mitomycin A Mitomycin A is a bacterial metabolite originally isolated from S. Mitomycin A Chemical Structure
  70. GC12353 Mitomycin C Mitomycin C is an antibiotic isolated from Streptomyces Caespitosus or Streptomyces Lavendulae. Mitomycin C inhibits DNA synthesis by forming covalent mitomycin C-DNA adducts with DNA, with an EC50 value of 0.14 μM in PC3 cells. Mitomycin C Chemical Structure
  71. GC67716 Mitonafide Mitonafide Chemical Structure
  72. GC32714 Mitoxantrone (mitozantrone) Mitoxantrone (mitozantrone) is a potent topoisomerase II inhibitor. Mitoxantrone (mitozantrone) Chemical Structure
  73. GC14363 Mitoxantrone HCl Mitoxantrone HCl is a potent topoisomerase II inhibitor. Mitoxantrone HCl Chemical Structure
  74. GC45998 Mitoxantrone-d8 An internal standard for the quantification of mitoxantrone Mitoxantrone-d8 Chemical Structure
  75. GC12756 MK-4827 hydrochloride MK-4827 hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. MK-4827 hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. MK-4827 hydrochloride Chemical Structure
  76. GC11537 MK-4827 tosylate MK-4827 tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. MK-4827 tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. MK-4827 tosylate Chemical Structure
  77. GC16374 MK-8776(SCH-900776) MK-8776(SCH-900776) (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. MK-8776(SCH-900776) shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively. MK-8776(SCH-900776) Chemical Structure
  78. GC18303 MKC-3946 MKC-3946 is an inhibitor of inositol-requiring enzyme 1α (IRE1α). MKC-3946 Chemical Structure
  79. GC32889 MKC8866 (IRE-1α inhibitor 1) MKC8866 (IRE-1α inhibitor 1), a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29μM in human vitro. MKC8866 (IRE-1α inhibitor 1) strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52μM and unstresses RPMI 8226 cells with an IC50 of 0.14μM. MKC8866 (IRE-1α inhibitor 1) inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth. MKC8866 (IRE-1α inhibitor 1) Chemical Structure
  80. GC32910 MKC9989 MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM. MKC9989 Chemical Structure
  81. GC50239 ML 315 hydrochloride Inhibitor of Clk and DYRK kinases ML 315 hydrochloride Chemical Structure
  82. GC17635 ML-323 USP1-UAF1 inhibitor ML-323 Chemical Structure
  83. GC14162 ML167 Clk4 inhibitor,highly selective ML167 Chemical Structure
  84. GC12786 ML216 BLM helicase inhibitor ML216 Chemical Structure
  85. GC32720 ML364 An inhibitor of USP2 ML364 Chemical Structure
  86. GC64666 ML372 ML372 Chemical Structure
  87. GC16914 MN 64 tankyrase inhibitor MN 64 Chemical Structure
  88. GC65435 Monalizumab

    Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A).

     Monalizumab Chemical Structure
  89. GC44243 Monohydroxy Melphalan (hydrochloride) Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan. Monohydroxy Melphalan (hydrochloride) Chemical Structure
  90. GC11114 Moxifloxacin HCl Moxifloxacin HCl (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. Moxifloxacin HCl Chemical Structure
  91. GC64729 MPT0B390 MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM. MPT0B390 Chemical Structure
  92. GC65965 MPT0E028 MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity. MPT0E028 Chemical Structure
  93. GC32746 MSC2530818 A Cdk8 inhibitor MSC2530818 Chemical Structure
  94. GC18769 MST-312 MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). MST-312 Chemical Structure
  95. GC44251 MTIC

    MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide.

     MTIC Chemical Structure
  96. GC15238 Mupirocin isoleucyl t-RNA synthetase inhibitor Mupirocin Chemical Structure
  97. GC12423 Mycophenolate mofetil hydrochloride Immunosuppresant drug Mycophenolate mofetil hydrochloride Chemical Structure
  98. GC49491 N′-Nitrosonornicotine-d4 An internal standard for the quantification of N’-nitrosonornicotine N′-Nitrosonornicotine-d4 Chemical Structure
  99. GC49163 N’-Nitrosonornicotine An N-nitrosamine and a carcinogen N’-Nitrosonornicotine Chemical Structure
  100. GC40683 N-(2-hydroxyethyl)-Naphthalimide N-(2-hydroxyethyl)-Naphthalimide is an N-substituted 1,8-naphthalimide used as a fluorescent probe and as a precursor for protection of amine groups. N-(2-hydroxyethyl)-Naphthalimide Chemical Structure
  101. GC40298 N-acetyl-5-Aminosalicylic Acid N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine. N-acetyl-5-Aminosalicylic Acid Chemical Structure

Items 801 to 900 of 1356 total

per page
  2. 7
  3. 8
  4. 9
  5. 10
  6. 11

Set Descending Direction