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Home >> Signaling Pathways >> Endocrinology and Hormones

Endocrinology and Hormones

Endocrinology and Hormones

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Targets for  Endocrinology and Hormones

Products for  Endocrinology and Hormones

  1. Cat.No. Product Name Information
  2. GC42322 4,4'-Dicyanobenzhydrol

    bis-(4-Cyanophenyl)methanol, bis(p-Cyanophenyl)methanol, CGP 44,645

     4,4'-Dicyanobenzhydrol is an analytical reference standard that is a metabolite of letrozole, an aromatase inhibitor that has been abused during sports doping cycles to reduce gynecomastia associated with androgen abuse. 4,4'-Dicyanobenzhydrol Chemical Structure
  3. GC91680 4-Acetamido Antipyrine

    4-AAAP,NSC 331807

     4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole . 4-Acetamido Antipyrine Chemical Structure
  4. GC48824 4-hydroxy Estrone

    4-hydroxy E1, 4-OHE1

     A metabolite of estrone 4-hydroxy Estrone Chemical Structure
  5. GC19552 4-Hydroxyestradiol

    4-Hydroxy-17β-estradiol

    4-Hydroxyestradiol, an metabolite of estradiol, forms adducts with adenine (3) and guanine (N7) by depurinating sites in DNA of cultured human breast epithelial cells.

     4-Hydroxyestradiol Chemical Structure
  6. GC17803 4-Hydroxytamoxifen

    Afimoxifene, 4-OHT

     4-hydroxytamoxifen is a major metabolite of tamoxifen and selective estrogen receptor antagonist. 4-Hydroxytamoxifen Chemical Structure
  7. GC49562 4-methoxy Estrone

    4-MeOE1, 4-methoxy E1

     An active metabolite of estrone 4-methoxy Estrone Chemical Structure
  8. GC11606 4-Methylbenzylidene camphor

    Enzacamene|Eusolex 6300|4-MBC|Neo Heliopan MBC|Parsol 500|Uvinul MBC 95

     ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities. 4-Methylbenzylidene camphor Chemical Structure
  9. GC42473 4-tert-Octylphenol diethoxylate

    OP2EO

     4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. 4-tert-Octylphenol diethoxylate Chemical Structure
  10. GC52365 4-tert-Octylphenol monoethoxylate

    NSC 5259, OP1EO

     An alkylphenolethoxylate and a degradation product of non-ionic surfactants 4-tert-Octylphenol monoethoxylate Chemical Structure
  11. GC13917 4’-hydroxy Tamoxifen metabolite of tamoxifen, an estrogen receptor modulator 4’-hydroxy Tamoxifen Chemical Structure
  12. GC40053 5α,6α-epoxy Cholestanol

    NSC 18176

     An oxysterol and a metabolite of cholesterol produced by oxidation 5α,6α-epoxy Cholestanol Chemical Structure
  13. GC42569 5α-Androst-16-en-3-one

    Androstenone

     5α-Androst-16-en-3-one is a mammalian pheromone released as a volatile chemical cue in boar saliva to facilitate social and sexual interactions. 5α-Androst-16-en-3-one Chemical Structure
  14. GC49542 5α-Androstan-3β-ol

    NSC 50887

     A steroidal androgen 5α-Androstan-3β-ol Chemical Structure
  15. GC48808 5β-Androstane-3α,17β-diol

    5β-Adiol, 5β-Androstanediol, β-Androstane-3α,17β-diol, Etiocholanediol

     A metabolite of testosterone 5β-Androstane-3α,17β-diol Chemical Structure
  16. GC49326 5β-Dihydroprogesterone

    5β-DHP, NSC 82868, 5β-Pregnanedione

     A progesterone receptor agonist and metabolite of progesterone 5β-Dihydroprogesterone Chemical Structure
  17. GC49176 5β-Tetrahydrocortisol

    NSC 57431

     An endogenous metabolite of cortisol 5β-Tetrahydrocortisol Chemical Structure
  18. GC46075 5,6-dimethyl-2-Thiouracil

    Dimethylthiouracil, NSC 60687

     A heterocyclic building block 5,6-dimethyl-2-Thiouracil Chemical Structure
  19. GC90889 5-(3'-Hydroxyphenyl)-γ-Valerolactone

    A metabolite of various polyphenols

     5-(3'-Hydroxyphenyl)-γ-Valerolactone Chemical Structure
  20. GC49827 5-Androstenetriol

    Δ5-AT

     An active metabolite of DHEA 5-Androstenetriol Chemical Structure
  21. GC90492 5-Dibromomethyl Anastrozole

    A synthetic intermediate of anastrozole

     5-Dibromomethyl Anastrozole Chemical Structure
  22. GC15774 5α-dihydro-11-keto Testosterone

    5α-Androstane-3,11-dione-17β-ol,11-keto Dihydrotestosterone,17β-hydroxy-5α-Androstane-3,11-dione

     5α-dihydro-11-keto Testosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 5α-dihydro-11-keto Testosterone Chemical Structure
  23. GC49676 6β-hydroxy Budesonide A metabolite of budesonide 6β-hydroxy Budesonide Chemical Structure
  24. GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone 6β-hydroxy Eplerenone Chemical Structure
  25. GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone 6β-hydroxy Prednisolone Chemical Structure
  26. GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs). 6-hydroxy Bexarotene Chemical Structure
  27. GC18432 6α-Naloxol

    6-hydroxy Naloxone, NLL

     An Analytical Reference Material 6α-Naloxol Chemical Structure
  28. GC18335 6β-hydroxy Dexamethasone

    6-hydroxyDEX, 6β-hydroxydexamethasone, 6OH-DEX

     6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. 6β-hydroxy Dexamethasone Chemical Structure
  29. GC19458 6β-hydroxy Testosterone

    4-Androsten-6β,17β-diol-3-one, 6β, 17β,-Dihydroxyandrost-4-en-3-one

     CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens. 6β-hydroxy Testosterone Chemical Structure
  30. GC49206 7α-hydroxy Dehydroepiandrosterone

    7α-hydroxy DHEA

     An active metabolite of dehydroepiandrosterone 7α-hydroxy Dehydroepiandrosterone Chemical Structure
  31. GC49391 7α-Thiospironolactone

    Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL

     An active metabolite of spironolactone 7α-Thiospironolactone Chemical Structure
  32. GC46740 7β,27-dihydroxy Cholesterol

    7β,27-DHC

     An oxysterol and agonist of RORγ and RORγt 7β,27-dihydroxy Cholesterol Chemical Structure
  33. GC63764 7-α-Methylthio Spironolactone-D3 7-α-Methylthio Spironolactone-D3 Chemical Structure
  34. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine 7-hydroxy Chlorpromazine (hydrochloride) Chemical Structure
  35. GC48880 7-Methoxyflavone A flavone with diverse biological activities 7-Methoxyflavone Chemical Structure
  36. GC17119 8-Prenylnaringenin

    Flavaprenin,8-PN

     estrogen receptor inhibitor 8-Prenylnaringenin Chemical Structure
  37. GC40464 9(R)-HETE

    9(R)-Hydroxyeicosatetraenoic Acid

     9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(R)-HETE Chemical Structure
  38. GC40465 9(S)-HETE

    9(S)-Hydroxyeicosatetraenoic Acid

     9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(S)-HETE Chemical Structure
  39. GC46754 9(S)-HETE-d8

    9(S)-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities 9(S)-HETE-d8 Chemical Structure
  40. GC14596 9-cis-Retinoic Acid

    Alitretinoin, NSC 659772, Panretin, 9-cis RA

     9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic Acid Chemical Structure
  41. GP10060 a-MSH, amide

    Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-amide, α-MSH, amide

     a-MSH (α-Melanocyte-Stimulating Hormone), amide engages the melanocortin-1 receptor and activates cyclic AMP (cAMP) signaling via a G-protein transporter, can synthesize melanin. a-MSH, amide Chemical Structure
  42. GC46768 Abaloparatide (acetate)

    BA 058, BIM 44058

     A synthetic derivative of PTHrP and an agonist of PTHR1 Abaloparatide (acetate) Chemical Structure
  43. GC38581 Abaloparatide TFA Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue selected to be a potent and selective activator of the PTHR1 signaling pathway. Abaloparatide TFA Chemical Structure
  44. GC45778 Abarelix (acetate) A synthetic GnRHR antagonist Abarelix (acetate) Chemical Structure
  45. GC32843 Abarelix (R3827) Abarelix (R3827) (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment. Abarelix (R3827) Chemical Structure
  46. GC35217 Abarelix Acetate Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. Abarelix Acetate Chemical Structure
  47. GC46775 Abiraterone Acetate-d4

    CB-7630-d4

     A neuropeptide with diverse biological activities Abiraterone Acetate-d4 Chemical Structure
  48. GC50091 AC 186 Potent and selective ERβ agonist; neuroprotective AC 186 Chemical Structure
  49. GC11852 AC 261066 Potent RARβ2 agonist AC 261066 Chemical Structure
  50. GC10871 AC 55649 RARβ2 agonist, potent and selective AC 55649 Chemical Structure
  51. GC46777 AC-262536 A selective androgen receptor modulator AC-262536 Chemical Structure
  52. GC91188 Acephate-d3

    An internal standard for the quantification of acephate

     Acephate-d3 Chemical Structure
  53. GP10059 Acetyl Angiotensinogen (1-14), porcine

    Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH

    Acetyl Angiotensinogen (1-14), porcine Chemical Structure
  54. GC17059 Acetyl Podocarpic Acid Anhydride

    APD

     LXR agonist Acetyl Podocarpic Acid Anhydride Chemical Structure
  55. GC64147 Acetyl tetrapeptide-15 Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 Chemical Structure
  56. GC17094 Acitretin

    all-trans Acitretin, Ro 10-1670, Ro 10-1670/000

    Metabolite of etretinate

     Acitretin Chemical Structure
  57. GC17113 Acitretin sodium Second-generation, systemic retinoid Acitretin sodium Chemical Structure
  58. GC31738 ACP-105 ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. ACP-105 Chemical Structure
  59. GC45372 ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    SYSMEHFRWGKPV-OH

       ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  60. GC45374 ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    Adrenocorticotropic Hormone (1-17), SYSMEHFRWGKPVGKKR-OH

       ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  61. GC92106 ACTH (11-24) (human, mouse, rat, porcine, bovine, ovine) (acetate)

    α11-24-ACTH; Adrenocorticotropic Hormone (11-24); Corticotropin (11-24)

     Adrenocorticotropic hormone (ACTH) (11-24) is a peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response, and an antagonist of MC2R. ACTH (11-24) (human, mouse, rat, porcine, bovine, ovine) (acetate) Chemical Structure
  62. GC92115 ACTH (3-24) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    Adrenocorticotropic Hormone (3-24); Corticotropin (3-24)

     Adrenocorticotropic hormone (ACTH) (3-24) is a potential impurity found in commercial preparations of tetracosactide, also known as cosyntropin, a synthetic form of ACTH (1-24). ACTH (3-24) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  63. GC92123 ACTH (7-38) (human) (trifluoroacetate salt)

    Adrenocorticotropic Hormone (7-38); α7-38-ACTH; CIP; Corticotropin Inhibitory Peptide

     Adrenocorticotropic hormone (ACTH) (7-38) is a peptide fragment of ACTH and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor. ACTH (7-38) (human) (trifluoroacetate salt) Chemical Structure
  64. GC31530 ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human)

    MEHFRWGK-OH

     ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM). ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) Chemical Structure
  65. GC71463 Acyline TFA Acyline TFA, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels. Acyline TFA Chemical Structure
  66. GC10610 Adapalene

    CD 271

     RARβ and RARγ agonist Adapalene Chemical Structure
  67. GC14379 Adapalene sodium salt Retinoic acid receptor agonist Adapalene sodium salt Chemical Structure
  68. GC46798 Adapalene-d3 An internal standard for the quantification of adapalene Adapalene-d3 Chemical Structure
  69. GC13959 Adarotene

    ST1926

     An atypical retinoid Adarotene Chemical Structure
  70. GC11829 ADL5859 HCl ADL5859 HCl (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL5859 HCl Chemical Structure
  71. GC67703 Adrenocorticotropic hormone TFA

    ACTH TFA; Adrenocorticotrophic hormone TFA

     Adrenocorticotropic hormone TFA Chemical Structure
  72. GC42741 Adrenomedullin (22-52) (human) (trifluoroacetate salt) Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52). Adrenomedullin (22-52) (human) (trifluoroacetate salt) Chemical Structure
  73. GP10109 Adrenorphin

    H2N-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-amide

    Adrenorphin Chemical Structure
  74. GC68629 AGN 192870

    AGN 192870 is a RAR neutral antagonist with Kd values of 147, 33, and 42 nM for RARα, RARβ, and RARγ respectively. The IC50 values for AGN 192870 are 87 and 32 nM for RARα and RARγ respectively. AGN 192870 exhibits partial agonistic activity on RARβ.

     AGN 192870 Chemical Structure
  75. GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 Chemical Structure
  76. GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. AGN 194078 Chemical Structure
  77. GC12598 AGN 194310

    VTP-194310

     pan-RAR antagonist AGN 194310 Chemical Structure
  78. GC35265 AGN 195183

    IRX-5183; VTP-195183; NRX-195183

     AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ. AGN 195183 Chemical Structure
  79. GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). AGN 196996 Chemical Structure
  80. GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. AGN 205327 Chemical Structure
  81. GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 Chemical Structure
  82. GC39584 AGN194204

    IRX4204; NRX194204; VTP 194204

     AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 Chemical Structure
  83. GC68630 AH3960

    AH3960 (compound 16c) is a androgen receptor antagonist. AH3960 can bind to both wild-type and T877 mutant androgen receptors, selectively inhibiting T877 (IC50=0.82 μM). AH3960 is also an agonist of the parathyroid hormone receptor PTHR1.

     AH3960 Chemical Structure
  84. GC31742 Ailanthone (δ13-Dehydrochaparrinone)

    Δ13-Dehydrochaparrinone

     Ailanthone (δ13-Dehydrochaparrinone) (δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309nM). Ailanthone (δ13-Dehydrochaparrinone) Chemical Structure
  85. GC12374 Alarelin Acetate

    pGlu-HWSYALRP-NHEt, D-Ala6, des-Gly10GnRH-ethylamide, des-Gly GnRH

     A peptide agonist of GnRH Alarelin Acetate Chemical Structure
  86. GC46827 Aldosterone 21-sulfate (sodium salt)

    Aldosterone 21-sulphate

    A metabolite of aldosterone

     Aldosterone 21-sulfate (sodium salt) Chemical Structure
  87. GC14511 all-trans Retinal

    Retinaldehyde,Vitamin A aldehyde

     converted to retinoic acid in vivo all-trans Retinal Chemical Structure
  88. GC40094 all-trans Retinoic Acid-d5

    atRA-d5, RA-d5, Vitamin A Acid-d5

     all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid by GC- or LC-MS. all-trans Retinoic Acid-d5 Chemical Structure
  89. GC42769 all-trans Retinoyl β-D-Glucuronide

    Retinoyl Glucuronide, Retinoyl β-D Glucuronide

     all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. all-trans Retinoyl β-D-Glucuronide Chemical Structure
  90. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol Chemical Structure
  91. GC18482 all-trans-5,6-epoxy Retinoic Acid

    5,6-epoxy-atRA, 5,6-epoxy RA

     all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). all-trans-5,6-epoxy Retinoic Acid Chemical Structure
  92. GC40024 Altenusin

    Alutenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

     Altenusin Chemical Structure
  93. GC13297 Altrenogest

    Allyltrenbolone, DRC 6246, RU 2267

     Progestogen receptor agonist Altrenogest Chemical Structure
  94. GC17623 Alvimopan

    ADL 8-2698, LY246736

     A μ-opioid receptor antagonist Alvimopan Chemical Structure
  95. GC12619 Alvimopan dihydrate A μ-opioid receptor antagonist Alvimopan dihydrate Chemical Structure
  96. GC35311 Alvimopan monohydrate Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan monohydrate Chemical Structure
  97. GC13664 AM580

    CD336, NSC 608001, Ro 406055

     Selective RARα agonist AM580 Chemical Structure
  98. GC16433 Aminoglutethimide

    DL-Aminoglutethimide, NSC 330915

     Aromatase inhibitor Aminoglutethimide Chemical Structure
  99. GC63932 Amsilarotene Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer. Amsilarotene Chemical Structure
  100. GC42793 Amylin (1-13) (human, mouse, rat), (trifluoroacetate salt)

    IAPP (1-13) (human, mouse rat), Islet Amyloid Polypeptide (1-13) (human. mouse, rat)

     Amylin (1-13) is a peptide fragment of amylin , which is a peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. Amylin (1-13) (human, mouse, rat), (trifluoroacetate salt) Chemical Structure
  101. GC42795 Amylin (human) (amidated) (trifluoroacetate salt)

    IAPP (human) (amidated), Islet Amyloid Polypeptide (human) (amidated)

     Amylin is a peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. Amylin (human) (amidated) (trifluoroacetate salt) Chemical Structure

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