DNA Damage/DNA Repair
- MTH1(4)
- PARP(84)
- ATM/ATR(30)
- DNA Alkylating(20)
- DNA Ligases(3)
- DNA Methyltransferase(25)
- DNA-PK(30)
- HDAC(136)
- Nucleoside Antimetabolite/Analogue(140)
- Telomerase(17)
- Topoisomerase(151)
- tankyrase(5)
- Antifolate(38)
- CDK(250)
- Checkpoint Kinase (Chk)(31)
- CRISPR/Cas9(9)
- Deubiquitinase(72)
- DNA Alkylator/Crosslinker(71)
- DNA/RNA Synthesis(400)
- Eukaryotic Initiation Factor (eIF)(23)
- IRE1(23)
- LIM Kinase (LIMK)(9)
- TOPK(5)
- Casein Kinase(61)
- DNA Intercalating Agents(7)
- DNA/RNA Oxidative Damage(12)
Products for DNA Damage/DNA Repair
- Cat.No. Product Name Information
- GC38000 β-Boswellic acid A pentacyclic triterpene with diverse bioactivities
- GC31365 γ-Oryzanol γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice.
- GC38194 (±)-10-Hydroxycamptothecin (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
- GC33107 (±)-BAY-1251152 (±)-BAY-1251152 ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.
-
GC10867
(+)-Aphidicolin
Aphidicolin ((+)-Aphidicolin), a reversible inhibitor of eukaryotic nuclear DNA replication, can block the cell cycle at the pre-S phase[1].
- GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin.
- GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin.
- GC32429 (-)-BAY-1251152 (-)-BAY-1251152 ((-)-BAY-1251152) is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.
- GC48635 (-)-Cryptopleurine An alkaloid with diverse biological activities
- GC40076 (-)-Voacangarine (-)-Voacangarine is an indole alkaloid originally isolated from V.
- GC38377 (2S,3R)-Voruciclib hydrochloride (2S,3R)-Voruciclib hydrochloride is the enantiomer of Voruciclib hydrochloride. (2S,3R)-Voruciclib is an orally active CDK inhibitor.
- GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
- GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
- GC62735 (E/Z)-GO289 (E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function.
- GC64429 (E/Z)-Zotiraciclib citrate (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor.
- GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent CDK2, JAK2, and FLT3 inhibitor.
-
GC69793
(R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose
(R)-5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.
- GC41716 (R)-CR8 Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.
- GC39281 (R)-CR8 trihydrochloride (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor.
- GC64210 (R)-GSK-3685032 (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition.
- GC41633 (R)-Prunasin (R)-Prunasin is a inhibitor of DNA Polymerase β.
- GC34124 (rel)-MC180295 (rel)-MC180295 ((rel)-(rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. (rel)-MC180295 also inhibits GSK-3α and GSK-3β. (rel)-MC180295 ((rel)-(rel)-MC180295) has potent anti-tumor effect.
- GC10098 (S)-10-Hydroxycamptothecin inhibitor of topoisomerase I
- GC34999 (S)-Ceralasertib (S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM.(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition.
- GC46351 (S)-CR8 An inhibitor of cyclin-dependent kinases
- GC13136 (S)-Crizotinib Potent MTH1 inhibitor
- GC65877 (S)-GFB-12811 (S)-GFB-12811 (compound 596) is a potent and selective CDK5 inhibitor, with an IC50 value less than 10 nM. (S)-GFB-12811 can be used in the research of cell cycle progression, neuronal development, tumorigenesis.
- GC65997 (S)-LY3177833 hydrate (S)-LY3177833 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor. (S)-LY3177833 hydrate shows broad in vitro anticancer activity.
- GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates.
- GC39842 (Z)-4EGI-1 (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity.
-
GC68484
1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose
1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target malignant tumors in the inert lymphatic system. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.
- GC19528 1,4-Benzoquinone A toxic metabolite of benzene
- GC41859 1,5,7-Triazabicyclo[4.4.0]dec-5-ene 1,5,7-Triazabicyclo[4.4.0]dec-5-ene is a bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations, including Michael additions, Wittig reactions, Henry reactions, and transesterification reactions.
- GC65551 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
- GC49470 1-Ethyl-1-nitrosourea (hydrate) A DNA alkylating agent
- GC48909 1-Hydroxyanthraquinone An anthraquinone with genotoxic and carcinogenic activities
- GC65038 1-Methylinosine 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.
- GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade) 10-Formyltetrahydrofolate (sodium salt) (technical grade) is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism.
- GC63796 116-9e 116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor.
- GC49759 13C17-Mycophenolic Acid An internal standard for the quantification of mycophenolic acid
- GC46474 18-Deoxyherboxidiene A bacterial metabolite with antiangiogenic activity
- GC65489 2'-F-Bz-dC Phosphoramidite 2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotides.
- GC66651 2'-O,4'-C-Methyleneadenosine 2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.
- GC66654 2'-O,4'-C-Methylenecytidine 2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands.
- GC66655 2'-O,4'-C-Methyleneguanosine 2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand.
- GC52183 2'-O-Methyl-5-methyluridine
- GC66713 2'-O-MOE-5-Me-C(Bz) 2'-O-MOE-5-Me-C (Bz) is a nucleotide for the stereoselective synthesis of nucleoside alkyl phosphonates.
- GC66657 2'-O-MOE-5-Me-rC 2'-O-MOE-5-Me-rC is an active compound. 2'-O-MOE-5-Me-rC can be used for oligonucleotide synthesis.
- GC66091 2'-O-MOE-5-Me-rU 2'-O-MOE-5-Me-rU is an active compound. 2'-O-MOE-5-Me-rU can be used for oligonucleotide synthesis.
- GC66656 2'-O-MOE-rC 2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA.
- GC66652 2'-O-MOE-U 2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis.
- GC65170 2′,3′-Di-O-acetylguanosine 2′,3′-Di-O-acetylguanosine is a nucleoside analog.
- GC67384 2′-Deoxy-β-L-uridine 2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase.
- GC61667 2′-Deoxy-2′-fluoroadenosine 2′-Deoxy-2′-fluoroadenosine can be used for thesynthesisof 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP.
- GC62530 2’-O-Me-C(Bz) Phosphoramidite 2’-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC62529 2’-OMe-A(Bz) Phosphoramidite 2’-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC62531 2’-OMe-G(ibu) Phosphoramidite 2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
- GC46508 2',2'-Difluoro-2'-deoxyuridine An active metabolite of gemcitabine
- GC42061 2',3'-Dideoxyadenosine 5'-triphosphate 2',3'-Dideoxyadenosine 5'-triphosphate (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase.
- GC46519 2',3'-O-Isopropylideneguanosine A building block
- GC46540 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate) A purine nucleotide
- GC48440 2'-Deoxycytidine-5'-triphosphate (sodium salt) 2'-Deoxycytidine-5'-triphosphate (sodium salt) (dCTP trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis.
- GC42151 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) 2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis.
- GC33430 2'-Deoxypseudoisocytidine 2'-Deoxypseudoisocytidine is a nucleoside analogue.
- GC35072 2'-O,4'-C-Methyleneuridine 2'-O,4'-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
- GC42080 2'2'-cGAMP (sodium salt) 2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds.
- GC64399 2,4,6-Trihydroxybenzoic acid 2,4,6-Trihydroxybenzoic acid, the flavonoid metabolite, is a CDK inhibitor. 2,4,6-Trihydroxybenzoic acid can be used for the research of cancer.
- GC60459 2,4-D (2,4-Dichlorophenoxyacetic acid) 2,4-D (2,4-Dichlorophenoxyacetic acid) (2,4-D (2,4-Dichlorophenoxyacetic acid) ichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds.
-
GC46524
2,6-Dichloropurine-9-β-D-riboside
A building block
- GC33496 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) (N2-Methylguanine) is a modified nucleoside.
- GC64983 2-Amino-2'-deoxyadenosine 2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.
- GC39527 2-O-Methylcytosine 2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase.
- GC49348 2-Thiocytidine A modified nucleobase
- GC42197 2-Thiouridine 2-Thiouridine (s2U) is a modified nucleobase found in tRNAs that is known to stabilize U:A pairs and modestly destabilize U:G wobble pairs.
- GC65083 3'-Azido-3'-deoxy-5-fluorocytidine 3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.
- GC64985 3'-O-Methylguanosine 3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator.
- GC40618 3',4',7-Trihydroxyisoflavone 3',4',7-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 3',4',7-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities.
- GC35105 3'-Azido-3'-deoxy-beta-L-uridine 3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative.
- GC60023 3'-Deoxyuridine-5'-triphosphate 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II.
- GC61862 3'-Deoxyuridine-5'-triphosphate trisodium 3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II.
- GC45332 3'-Dephosphocoenzyme A An intermediate in the biosynthesis of CoA
- GC34384 3,6-DMAD hydrochloride 3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer.
- GC34452 3,7,4'-Trihydroxyflavone 3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var.
- GC52129 3-Amino-5-hydroxybenzoic Acid
- GC13510 3-AP ribonucleotide reductase inhibitor and iron chelator with antitumor activity
- GC48457 3-keto Fusidic Acid An active metabolite of fusidic acid
- GC65084 3-Methylcytidine 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
- GC52391 306-O12B-3 An ionizable cationic lipidoid
- GC15389 360A
- GC10115 360A iodide
-
GC14493
4μ8C
IRE1 Rnase inhibitor, potent and non-toxic
- GC17271 4'-Demethylepipodophyllotoxin An inhibitor of tubulin polymerization
- GC46607 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone A tobacco-specific nitrosamine carcinogen
- GC11761 4-amino-1,8-Naphthalimide 4-amino-1,8-Naphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells.
- GC42401 4-hydroperoxy Cyclophosphamide An activated analog of cyclophosphamide
- GC68332 4-Hydroperoxy Cyclophosphamide-d4
- GC18853 4-isocyanato TEMPO 4-isocyanato TEMPO is a spin labeling reagent used to label the 2'-position in RNA.
- GC61683 4-Methoxyphenethyl alcohol 4-Methoxyphenethyl alcohol, an aromatic alcohol, is the major component in the anise-like odour produced by A.
- GC49127 4-oxo Cyclophosphamide An inactive metabolite of cyclophosphamide
-
GC42464
4-oxo-2-Nonenal
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.