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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GA21951 H-4-Nitro-Phe-OEt . HCl A building block H-4-Nitro-Phe-OEt . HCl Chemical Structure
  3. GC49305 H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt) An RGD-containing tetrapeptide H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt) Chemical Structure
  4. GA22303 H-D-Pro-Phe-Arg-pNA . 2 HCl pFR-pNA, chromogenic substrate for the determination of plasma kallikrein-like activity. CAS Number (net): 64816-19-9. H-D-Pro-Phe-Arg-pNA . 2 HCl Chemical Structure
  5. GC45471 H-Gly-Arg-pNA (hydrochloride)   H-Gly-Arg-pNA (hydrochloride) Chemical Structure
  6. GC49605 H-Gly-Pro-Hyp-OH (acetate) A peptide DPP-4 inhibitor H-Gly-Pro-Hyp-OH (acetate) Chemical Structure
  7. GC43803 HA-1077 (hydrochloride) Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. HA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator. HA-1077 (hydrochloride) Chemical Structure
  8. GC43805 HAPC-Chol HAPC-Chol is a cationic cholesterol. HAPC-Chol Chemical Structure
  9. GC49855 Harmalol (hydrochloride hydrate) A β-carboline alkaloid and an active metabolite of harmaline Harmalol (hydrochloride hydrate) Chemical Structure
  10. GC49915 Hexa-D-Arginine (trifluoroacetate salt) A furin inhibitor Hexa-D-Arginine (trifluoroacetate salt) Chemical Structure
  11. GC45639 Hexapeptide-11 (acetate) A synthetic hexapeptide Hexapeptide-11 (acetate) Chemical Structure
  12. GC43832 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Chemical Structure
  13. GC13928 HMN-214 Plk inhibitor,broad-spectrum anti-tumor agent HMN-214 Chemical Structure
  14. GC62594 hnRNPK-IN-1 hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities. hnRNPK-IN-1 Chemical Structure
  15. GC49742 Hsf1 Monoclonal Antibody (Clone 10H8) For immunochemical analysis of Hsf1 Hsf1 Monoclonal Antibody (Clone 10H8) Chemical Structure
  16. GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin HT-2 Toxin-13C22 Chemical Structure
  17. GC10901 Hydroxyfasudil Hydroxyfasudil Chemical Structure
  18. GC10338 Hydroxyfasudil hydrochloride A ROCK inhibitor Hydroxyfasudil hydrochloride Chemical Structure
  19. GC32912 IBR2 IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis. IBR2 Chemical Structure
  20. GC45743 ICAAc A solvatochromic fluorophore and pH probe ICAAc Chemical Structure
  21. GC34159 Ilorasertib (ABT-348) Ilorasertib (ABT-348) (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib (ABT-348) also is a potent VEGF, PDGF inhibitor. Ilorasertib (ABT-348) has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Ilorasertib (ABT-348) Chemical Structure
  22. GC38519 Ilorasertib hydrochloride Ilorasertib (ABT-348) hydrochloride is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Ilorasertib hydrochloride Chemical Structure
  23. GC36308 Indibulin An inhibitor of microtubule assembly Indibulin Chemical Structure
  24. GC52513 Indolimine-214 A genotoxic gut microbiota metabolite Indolimine-214 Chemical Structure
  25. GC49460 ING-2 AM A cell-permeable fluorescent sodium indicator ING-2 AM Chemical Structure
  26. GC10334 INH6 Hec1/Nek2 inhibitor, potent INH6 Chemical Structure
  27. GC48387 Inostamycin A A bacterial metabolite with anticancer activity Inostamycin A Chemical Structure
  28. GC52472 Inostamycin A (sodium salt) A bacterial metabolite with anticancer activity Inostamycin A (sodium salt) Chemical Structure
  29. GC16225 IPA-3

    Non-ATP competitive Pak1 inhibitor

     IPA-3 Chemical Structure
  30. GC49468 IPG-1 AM A cell-permeable fluorescent potassium indicator IPG-1 AM Chemical Structure
  31. GC49469 IPG-1 TMA A cell-impermeable fluorescent potassium indicator IPG-1 TMA Chemical Structure
  32. GC49463 IPG-2 AM A cell-permeable fluorescent potassium indicator IPG-2 AM Chemical Structure
  33. GC49466 IPG-2 TMA A cell-impermeable fluorescent potassium indicator IPG-2 TMA Chemical Structure
  34. GC65188 IRES-C11 IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes. IRES-C11 Chemical Structure
  35. GC15215 Iso-Olomoucine inactive stereoisomer of the Cdk5 inhibitor olomoucine Iso-Olomoucine Chemical Structure
  36. GC40901 Isogarcinol Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. Isogarcinol Chemical Structure
  37. GC43917 Isopropyl Benzenesulfonate Isopropyl benzenesulfonate is a sulfonate ester genotoxic impurity found in active pharmaceutical ingredients. Isopropyl Benzenesulfonate Chemical Structure
  38. GC49142 Isorhoifolin A flavonoid glycoside with diverse biological activities Isorhoifolin Chemical Structure
  39. GC43922 Isovaleryl-L-carnitine (chloride) Isovaleryl-L-carnitine (chloride), a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils. Isovaleryl-L-carnitine (chloride) Chemical Structure
  40. GC13394 Ispinesib (SB-715992) Ispinesib (SB-715992) is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM. Ispinesib (SB-715992) Chemical Structure
  41. GC10581 ISRIB PERK signaling inhibitor ISRIB Chemical Structure
  42. GC16869 Ixabepilone A broad-spectrum anticancer agent Ixabepilone Chemical Structure
  43. GC65331 IZCZ-3 IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity. IZCZ-3 Chemical Structure
  44. GC41645 Jacaric Acid Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Jacaric Acid Chemical Structure
  45. GC18699 JCP174 An inhibitor of palmitoyl protein thioesterase-1 JCP174 Chemical Structure
  46. GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. JS-K Chemical Structure
  47. GC16167 K 858 K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. K 858 Chemical Structure
  48. GC17388 K-Ras(G12C) inhibitor 6 K-Ras (G12C) inhibitor K-Ras(G12C) inhibitor 6 Chemical Structure
  49. GC14230 K03861 K03861 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. K03861 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins. K03861 Chemical Structure
  50. GC43994 KAPA (hydrochloride)

    Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals.

     KAPA (hydrochloride) Chemical Structure
  51. GC43995 Kazusamycin B Kazusamycin B is a bacterial metabolite originally isolated from Streptomyces. Kazusamycin B Chemical Structure
  52. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone Chemical Structure
  53. GC14589 KF 38789

    Selective inhibitor of P-selectin-mediated cell adhesion

     KF 38789 Chemical Structure
  54. GC16603 Kif15-IN-1 potent Kif15 kinesin inhibitor Kif15-IN-1 Chemical Structure
  55. GC17994 Kif15-IN-2 potent Kif15 kinesin inhibitor Kif15-IN-2 Chemical Structure
  56. GC64085 KIF18A-IN-1 KIF18A-IN-1 is a mitotic kinesin KIF18A inhibitor extracted from patent WO2021026098A1 example 100-13. KIF18A-IN-1 Chemical Structure
  57. GC64808 KIF18A-IN-2 KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer. KIF18A-IN-2 Chemical Structure
  58. GC64857 KIF18A-IN-3 KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer. KIF18A-IN-3 Chemical Structure
  59. GC69333 KIF18A-IN-7

    KIF18A-IN-7 (Compound 22) is an orally active inhibitor of KIF18A that inhibits the microtubule-dependent ATPase activity of KIF18A with an IC50 value of 9.4 nM.

     KIF18A-IN-7 Chemical Structure
  60. GC14413 KJ Pyr 9 c-Myc inhibitor, cell-permeable KJ Pyr 9 Chemical Structure
  61. GC14517 KPT-185

    CRM1 inhibitor,selective and irrversible

     KPT-185 Chemical Structure
  62. GC12142 KPT-276 inhibitor of nuclear export (SINE) and CRM1, orally bioavailable KPT-276 Chemical Structure
  63. GC12467 KPT-330 CRM1 inhibitor, orally bioavailable and selective KPT-330 Chemical Structure
  64. GC14615 KPT-9274 Orally acitve allosteric inhibitor of PAK4 KPT-9274 Chemical Structure
  65. GC18909 KRIBB3

    KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner.

     KRIBB3 Chemical Structure
  66. GC33377 KSI-3716 KSI-3716 is a potent c-Myc inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer. KSI-3716 Chemical Structure
  67. GC33404 KU 59403 KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively. KU 59403 Chemical Structure
  68. GC12054 KU-60019 ATM kinase inhibitor,potent and selective KU-60019 Chemical Structure
  69. GC47532 KUS121 A VCP modulator KUS121 Chemical Structure
  70. GC14288 KX2-391 KX2-391 (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. KX2-391 Chemical Structure
  71. GC10222 KX2-391 dihydrochloride A Src kinase inhibitor KX2-391 dihydrochloride Chemical Structure
  72. GC12817 K–115 hydrochloride dihydrate K-115 hydrochloride dihydrate (K-115) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. K–115 hydrochloride dihydrate Chemical Structure
  73. GC44020 L-681,217 L-681,217 is an antibiotic originally isolated from S. L-681,217 Chemical Structure
  74. GC40793 L-erythro Sphinganine (d18:0) L-erythro Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and D-threo sphinganine. L-erythro Sphinganine (d18:0) Chemical Structure
  75. GC49547 L-Glutamic Acid γ-p-Nitroanilide (hydrate) A colorimetric substrate for γ-glutamyl transpeptidase L-Glutamic Acid γ-p-Nitroanilide (hydrate) Chemical Structure
  76. GC49205 L-Leu-AMC (hydrochloride) L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leu-AMC (hydrochloride) Chemical Structure
  77. GC44081 L-myo-Inositol-1,4,5-triphosphate (sodium salt) Ins(1,4,5)P3 is an isomer of the biologically important D-myo-inositol-1,4,5-triphosphate. L-myo-Inositol-1,4,5-triphosphate (sodium salt) Chemical Structure
  78. GC41520 Lachnone A Lachnone A is a chromone fungal metabolite originally isolated from Lachnum. Lachnone A Chemical Structure
  79. GC49471 LAMP1 Monoclonal Antibody (Clone Ly1C6) For immunochemical analysis of LAMP1 LAMP1 Monoclonal Antibody (Clone Ly1C6) Chemical Structure
  80. GC41272 Lateropyrone Lateropyrone is a fungal metabolite produced by Fusarium species. Lateropyrone Chemical Structure
  81. GC15671 Latrunculin A

    A reversible inhibitor of actin assembly

     Latrunculin A Chemical Structure
  82. GC50052 Laulimalide

    Microtubule stabilzing agent

     Laulimalide Chemical Structure
  83. GC50214 LCB 03-0110 dihydrochloride Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk LCB 03-0110 dihydrochloride Chemical Structure
  84. GC39209 LCH-7749944 LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 Chemical Structure
  85. GC17067 LDC000067 CDK9 inhibitor, novel and highly specific LDC000067 Chemical Structure
  86. GC33086 LDN-192960 LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively. LDN-192960 Chemical Structure
  87. GC44047 LDN-192960 (hydrochloride) LDN-192960 is an inhibitor of haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. LDN-192960 (hydrochloride) Chemical Structure
  88. GC38403 LDN-192960 hydrochloride LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively. LDN-192960 hydrochloride Chemical Structure
  89. GC10842 LEE011 LEE011 (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 Chemical Structure
  90. GC15922 LEE011 hydrochloride LEE011 hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 hydrochloride Chemical Structure
  91. GC15377 LEE011 succinate LEE011 succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. LEE011 succinate Chemical Structure
  92. GC49751 Lefamulin Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin Chemical Structure
  93. GC18345 Leptomycin A Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A Chemical Structure
  94. GC10954 Leptomycin B Leptomycin B (LMB) is an inhibitor of chromosome region maintenance 1 (CRM1) that is one of the nuclear protein exporters. Leptomycin B Chemical Structure
  95. GC33175 Lexibulin dihydrochloride (CYT-997 dihydrochloride) Lexibulin dihydrochloride (CYT-997 dihydrochloride) (CYT-997 dihydrochloride) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin dihydrochloride (CYT-997 dihydrochloride) induces cell apoptosis and induces mitochondrial ROS generation in GC cells. Lexibulin dihydrochloride (CYT-997 dihydrochloride) Chemical Structure
  96. GC14857 LFM-A13 BTK-specific tyrosine kinase inhibitor LFM-A13 Chemical Structure
  97. GC31803 Litronesib (LY-2523355) Litronesib (LY-2523355) (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity. Litronesib (LY-2523355) Chemical Structure
  98. GC30393 Litronesib Racemate (LY-2523355 Racemate) Litronesib Racemate (LY-2523355 Racemate) (LY2523355 Racemate) is the racemate of litronesib. Litronesib Racemate (LY-2523355 Racemate) Chemical Structure
  99. GC61014 Lusianthridin Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling. Lusianthridin Chemical Structure
  100. GC12402 LX7101 HCL LX7101 HCL is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM. LX7101 HCL Chemical Structure
  101. GC15741 LY2603618 LY2603618 (LY2603618) is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM. LY2603618 Chemical Structure

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