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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC50043 SR 3677 dihydrochloride Potent, selective Rho-kinase (ROCK) inhibitor SR 3677 dihydrochloride Chemical Structure
  3. GC10722 SR-3677 Rho Kinase (ROCK-II) inhibitor SR-3677 Chemical Structure
  4. GC44947 SRS16-86 A ferroptosis inhibitor SRS16-86 Chemical Structure
  5. GC37678 SS28 SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin. SS28 Chemical Structure
  6. GC48101 SSAA09E1 A SARS-CoV entry inhibitor SSAA09E1 Chemical Structure
  7. GC33074 SSE15206 SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. SSE15206 Chemical Structure
  8. GC52293 STAT3 Inhibitor 4m

    Signal Transducer and Activator of Transcription 3 Inhibitor 4m

     A STAT3 inhibitor STAT3 Inhibitor 4m Chemical Structure
  9. GC17839 Stauprimide

    NBenzoyl7oxo Staurosporine

     Small molecule that primes embryonic stem cells (ESCs) for differentiation Stauprimide Chemical Structure
  10. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  11. GC15571 SU 9516 A pro-apoptotic Cdk2/cyclin A inhibitor SU 9516 Chemical Structure
  12. GC18565 Suc-AAP-Abu-pNA

    Elastase Colorimetric Substrate IV

     Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase. Suc-AAP-Abu-pNA Chemical Structure
  13. GC52447 Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)

    Suc-LLVY-AMC

     A fluorogenic substrate for the 20S proteasome and calpains Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) Chemical Structure
  14. GC44963 Suc-Leu-Tyr-AMC

    SucLYAMC

     The calpains are a family of calcium-dependent cysteine proteases, with calpain I (μ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Suc-Leu-Tyr-AMC Chemical Structure
  15. GA23570 Suc-Tyr-Val-Ala-Asp-pNA

    Caspase-1 and Caspase-4 Chromogenic Substrate, Suc-Tyr-Val-Ala-Asp-p-nitroanilide

     Suc-YVAD-pNA, a chromogenic caspase-1 substrate. Suc-Tyr-Val-Ala-Asp-pNA Chemical Structure
  16. GC44967 Suc-YVAD-AMC (acetate)

    Suc-Tyr-Val-Ala-Asp-AMC, Suc-Tyr-Val-Ala-Asp-7-amino-4-methylcoumarin, Suc-YVAD-NH-Mec

     Suc-YVAD-AMC is a fluorogenic substrate for caspase-1. Suc-YVAD-AMC (acetate) Chemical Structure
  17. GC48119 Suprafenacine

    SML1493

     An inhibitor of tubulin polymerization with anticancer activity Suprafenacine Chemical Structure
  18. GC50529 Surfen

    Aminoquincarbamide dihydrochloride

     Surfen is a potent HS (heparan sulfate) antagonist. Surfen Chemical Structure
  19. GC44976 Swinholide A

    Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

     Swinholide A Chemical Structure
  20. GC48764 Sydowinin B

    MS-347b

     A xanthone polyketide with immunosuppressant activity Sydowinin B Chemical Structure
  21. GA23633 T-Peptide Highly neurotoxic cell-permeable analog of PHF6. Induces aggregation of Tau peptides. T-Peptide Chemical Structure
  22. GC37715 Taccalonolide A Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells. Taccalonolide A Chemical Structure
  23. GC37716 Taccalonolide AJ Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells. Taccalonolide AJ Chemical Structure
  24. GC37717 Taccalonolide B Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM. Taccalonolide B Chemical Structure
  25. GC17559 TAI-1 Hec1 inhibitor, potent, first-in-class TAI-1 Chemical Structure
  26. GC37725 TAK-960 dihydrochloride TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts. TAK-960 dihydrochloride Chemical Structure
  27. GC37726 TAK-960 hydrochloride TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 hydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts. TAK-960 hydrochloride Chemical Structure
  28. GC10773 TAK960

    Oral and selective PLK1 inhibitor

     TAK960 Chemical Structure
  29. GC32753 Taltobulin (HTI-286)

    Taltobulin, SPA 110

     Taltobulin (HTI-286) (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin (HTI-286) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin (HTI-286) Chemical Structure
  30. GC61314 Taltobulin hydrochloride

    HTI-286 hydrochloride; SPA-110 hydrochloride

     Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin hydrochloride Chemical Structure
  31. GC34303 Taltobulin hydrochloride (HTI-286 hydrochloride) Taltobulin hydrochloride (HTI-286 hydrochloride) Chemical Structure
  32. GC34135 Taltobulin trifluoroacetate (HTI-286 trifluoroacetate)

    HTI-286 trifluoroacetate; SPA-110 trifluoroacetate

     Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) Chemical Structure
  33. GC41443 TAN 1364B

    RK-682 (rac-1)

     TAN 1364B, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. TAN 1364B inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively. TAN 1364B Chemical Structure
  34. GC33178 Tasidotin hydrochloride (ILX651) Tasidotin hydrochloride (ILX651) is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics. Tasidotin hydrochloride (ILX651) Chemical Structure
  35. GC63211 Tau tracer 2

    Pl-2620

     Tau tracer 2 (Pl-2620) is a Tau tracer used for imaging Tau protein aggregates. Tau tracer 2 Chemical Structure
  36. GC13727 TC Mps1 12 Mps1 inhibitor TC Mps1 12 Chemical Structure
  37. GC16771 TC-S 7005 polo-like kinase 2 (PLK2) inhibitor TC-S 7005 Chemical Structure
  38. GC10793 TCS 2312 checkpoint kinase 1 (chk1) inhibitor TCS 2312 Chemical Structure
  39. GC45013 Tenuazonic Acid (copper salt)

    AAC-toxin

     Tenuazonic acid is one of the major Alternaria mycotoxins commonly found as a natural contaminant in food (LD50 = 548 μg/egg in the chicken embryo toxicity assay). Tenuazonic Acid (copper salt) Chemical Structure
  40. GC45014 Termitomycamide B Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. Termitomycamide B Chemical Structure
  41. GC45015 Termitomycamide E

    2'Deoxotermitomycamide A

     Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. Termitomycamide E Chemical Structure
  42. GC45022 Tetranactin Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. Tetranactin Chemical Structure
  43. GC49735 Thallos AM

    Thallos Acetoxymethyl ester

     A cell-permeable fluorescent thallium indicator Thallos AM Chemical Structure
  44. GC11181 Thiazovivin

    Tzv

     ROCK inhibitor Thiazovivin Chemical Structure
  45. GC45039 Thiocolchicine

    NSC 186301

     Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 μM) and a derivative of colchicine. Thiocolchicine Chemical Structure
  46. GC68366 Thiocolchicine-d3 Thiocolchicine-d3 Chemical Structure
  47. GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan Thiorphan-d5 Chemical Structure
  48. GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate)

    Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2

     An actin-sequestering peptide Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) Chemical Structure
  49. GC32448 Thymosin beta 4 (Thymosin β4) Thymosin β4 is a major actin sequestering protein in cells and can interact with G-actin. Thymosin beta 4 (Thymosin β4) Chemical Structure
  50. GC10840 THZ1 Covalent CDK7 inhibitor,potent and selective THZ1 Chemical Structure
  51. GC12642 THZ1 Hydrochloride CDK7 inhibitor THZ1 Hydrochloride Chemical Structure
  52. GC13511 THZ2 CDK7 inhibitor THZ2 Chemical Structure
  53. GC16420 THZ531 CDK12 and CDK13 covalent inhibitor THZ531 Chemical Structure
  54. GC70030 Tinengotinib

    Tinengotinib is a regulator of one or more protein kinases, such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential to study diseases mediated by these kinase abnormalities, especially cancer-related diseases (excerpt from patent WO2018108079A1).

     Tinengotinib Chemical Structure
  55. GC34109 Tirbanibulin Mesylate (KX2-391 (Mesylate))

    KX2-391 Mesylate; KX01 Mesylate

     Tirbanibulin Mesylate (KX2-391 (Mesylate)) (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Tirbanibulin Mesylate (KX2-391 (Mesylate)) Chemical Structure
  56. GC16413 TMCB

    CK2 and ERK8 inhibitor

     TMCB Chemical Structure
  57. GC12092 TMPyP4 tosylate

    TMP-1363, TMPyP4 4-methylbenzenesulfonate

     A human telomerase inhibitor TMPyP4 tosylate Chemical Structure
  58. GC18763 TN-16

    NSC 239274

     TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). TN-16 Chemical Structure
  59. GC45066 Tosyl Phenylalanyl Chloromethyl Ketone

    Nα-Tosyl-L-Phenylalanine Chloromethyl Ketone, TPCK

     Tosyl Phenylalanyl Chloromethyl Ketone (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-Tosyl Phenylalanyl Chloromethyl Ketone) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. Tosyl Phenylalanyl Chloromethyl Ketone Chemical Structure
  60. GC49072 Tribenoside A vasoprotective agent Tribenoside Chemical Structure
  61. GC10537 Triclabendazole

    TCBZ

     Microtubule associated inhibitor Triclabendazole Chemical Structure
  62. GC49685 Trifluoroacetyl Tripeptide-2 (acetate)

    F3Ac-Val-Tyr-Val

     A peptide inhibitor of pancreatic and neutrophil elastases Trifluoroacetyl Tripeptide-2 (acetate) Chemical Structure
  63. GC45086 Trigalacturonic Acid

    Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 μg/plant).

     Trigalacturonic Acid Chemical Structure
  64. GC45089 Trinactin Trinactin is a macrotetrolide antibiotic produced by Streptomyces and an ionophore for monovalent cations, such as sodium, potassium, and ammonium. Trinactin Chemical Structure
  65. GC33291 Tubulin inhibitor 1 Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis. Tubulin inhibitor 1 Chemical Structure
  66. GC70076 Tubulin inhibitor 11

    Tubulin inhibitor 11 is an effective orally active inhibitor of microtubules, which targets the colchicine binding site on tubulin. It inhibits microtubule polymerization, promotes mitotic arrest and induces apoptosis in cells.

     Tubulin inhibitor 11 Chemical Structure
  67. GC39558 Tubulin inhibitor 6

    Improved Heterocyclic Activator of PP2A 1, Tubulin Inhibitor 6

     An inhibitor of tubulin polymerization and a PP2A activator Tubulin inhibitor 6 Chemical Structure
  68. GC37835 Tubulysin Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system. Tubulysin Chemical Structure
  69. GC33155 Tubulysin A (TubA) Tubulysin A (TubA)(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysin A (TubA) Chemical Structure
  70. GC37836 Tubulysin B Tubulysin B Chemical Structure
  71. GC37837 Tubulysin C Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin C Chemical Structure
  72. GC37838 Tubulysin D Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin D Chemical Structure
  73. GC37839 Tubulysin E Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin E Chemical Structure
  74. GC37840 Tubulysin F Tubulysin F is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin F is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin F Chemical Structure
  75. GC37841 Tubulysin G Tubulysin G is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin G is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin G Chemical Structure
  76. GC37842 Tubulysin H Tubulysin H is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin H is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin H Chemical Structure
  77. GC37843 Tubulysin I Tubulysin I is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin I Chemical Structure
  78. GC37844 Tubulysin M Tubulysin M is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin M is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin M Chemical Structure
  79. GC49835 Tumulosic Acid

    Polyporenic Acid B

     Tumulosic Acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic Acid Chemical Structure
  80. GC50056 UA 62784 Inhibits microtubule polymerization UA 62784 Chemical Structure
  81. GC48659 Umbelliprenin

    7-Farnesyloxycoumarin

     A prenylated coumarin with diverse biological activities Umbelliprenin Chemical Structure
  82. GC16741 UNC0379 N-lysine methyltransferase SETD8 inhibitor UNC0379 Chemical Structure
  83. GC33269 Valecobulin (CKD-516)

    CKD-516

     Valecobulin (CKD-516) (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin (CKD-516) is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. Valecobulin (CKD-516) Chemical Structure
  84. GC39177 Valecobulin hydrochloride

    CKD-516 hydrochloride

     Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. Valecobulin hydrochloride Chemical Structure
  85. GC45769 Vandetanib-d6

    ZD6474-d6

     An internal standard for the quantification of vandetanib Vandetanib-d6 Chemical Structure
  86. GC38480 Vat-Cit-PAB-Monomethyl Dolastatin 10 Vat-Cit-PAB-Monomethyl Dolastatin 10 is a drug-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB. Vat-Cit-PAB-Monomethyl Dolastatin 10 Chemical Structure
  87. GC37890 Vc-MMAD Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD). Vc-MMAD is a drug-linker conjugate for ADC. Vc-MMAD Chemical Structure
  88. GC37891 VcMMAE

    MC-VC-PAB-MMAE, Vedotin

     VcMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). VcMMAE Chemical Structure
  89. GC10293 VE-821

    ATR Inhibitor IV

    ATR kinase inhibitor

     VE-821 Chemical Structure
  90. GC15337 VE-822 ATR inhibitor VE-822 Chemical Structure
  91. GC15777 Verdinexor (KPT-335)

    KPT-335

     XPO1/CRM1 inhibitor Verdinexor (KPT-335) Chemical Structure
  92. GC63253 Verosudil

    AR-12286

     Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil Chemical Structure
  93. GC37899 VERU-111

    VERU-111; ABI-231

     VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer. VERU-111 Chemical Structure
  94. GC37900 Verubulin Verubulin (MPC-6827) is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities, and acts as a promising candidate for the treatment of multiple cancer types. Verubulin Chemical Structure
  95. GC52364 Vimentin (139-159)-biotin Peptide

    VIM (139-159)-biotin

     A biotinylated vimentin peptide Vimentin (139-159)-biotin Peptide Chemical Structure
  96. GC52371 Vimentin (G146R) (139-159)-biotin Peptide

    Biotin-GQGKSRLRDLYEEEMRELRRQ, Biotin-GQGKSRLRDLYEEEMRELRRQ (X=Citrulline), VIM (G146R) (139-159)-biotin

     A biotinylated mutant vimentin peptide Vimentin (G146R) (139-159)-biotin Peptide Chemical Structure
  97. GC12286 Vinblastine sulfate

    29060LE, AlkabanAQ, Exal, NSC 49842, Rozevinsulfate, Velban, Velsar, Vincaleukoblastinesulfate, VLB

     An inhibitor of microtubule assembly Vinblastine sulfate Chemical Structure
  98. GC38410 Vincristine Vincristine Chemical Structure
  99. GC11511 Vincristine sulfate

    Kyocristine, Lilly 37231, Leurocristine, Novopharm, NSC 67574, Oncovin, VCR

     Microtubule disrupter,antitumor agent Vincristine sulfate Chemical Structure
  100. GC64451 Vincristine-d3-ester sulfate Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM. Vincristine-d3-ester sulfate Chemical Structure
  101. GC64915 Vindesine sulfate Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 ?M. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo. Vindesine sulfate Chemical Structure

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