Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Proteases

Proteases

Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Targets for  Proteases

Products for  Proteases

  1. Cat.No. Product Name Information
  2. GC31602 Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) (cis-7,10,13,16-Docosatetraenoic acid) is a naturally polyunsaturated fatty acid in the adrenal gland, brain, kidney, and vasculature. Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) Chemical Structure
  3. GC42742 ADT-OH ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. ADT-OH Chemical Structure
  4. GC32016 AE-3763 AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM. AE-3763 Chemical Structure
  5. GC14502 AEBSF.HCl

    AEBSF.HCl is a broad-spectrum irreversible inhibitor of serine proteases, which can inhibit chymotrypsin, kallikrein, plasmin, thrombin, trypsin and related thrombolytic enzymes.

     AEBSF.HCl Chemical Structure
  6. GC35261 Aflatoxin B1 Aflatoxin B1, as a class of carcinogenic mycotoxins produced by Aspergillus fungi, always lead to the development of hepatocellular carcinoma (HCC) in humans and animals. Aflatoxin B1 Chemical Structure
  7. GC46812 Aflatoxin G1-13C17 An internal standard for the quantification of aflatoxin G1 Aflatoxin G1-13C17 Chemical Structure
  8. GC35262 Afzelin A polyphenolic glycoside flavone with diverse biological activities Afzelin Chemical Structure
  9. GC15601 AG-120 AG-120 (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. AG-120 Chemical Structure
  10. GC13147 AG-221 (Enasidenib) AG-221 (Enasidenib) is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively. AG-221 (Enasidenib) Chemical Structure
  11. GC63642 Agaric acid Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i. Agaric acid Chemical Structure
  12. GC10531 AGI-5198 A potent, selective inhibitor of IDH1 mutations AGI-5198 Chemical Structure
  13. GC14757 AGI-6780 A potent, selective inhibitor of mutant IDH2 AGI-6780 Chemical Structure
  14. GC16831 Agmatine sulfate α2-adrenergic receptor ligand Agmatine sulfate Chemical Structure
  15. GC16138 AHU-377 hemicalcium salt AHU-377 hemicalcium salt (AHU-377 hemicalcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 hemicalcium salt Chemical Structure
  16. GC10146 AHU-377(Sacubitril) AHU-377(Sacubitril) (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. AHU-377(Sacubitril) Chemical Structure
  17. GC46820 AHU377-d4 AHU377-d4 (AHU-377-d4) is the deuterium labeled Sacubitril. AHU377-d4 Chemical Structure
  18. GC49773 Albendazole sulfone-d3 An internal standard for the quantification of albendazole sulfone Albendazole sulfone-d3 Chemical Structure
  19. GC16597 Alda 1

    ALDH2 activator

     Alda 1 Chemical Structure
  20. GC64063 ALDH1A1-IN-2 ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295). ALDH1A1-IN-2 Chemical Structure
  21. GC67782 ALDH1A2-IN-1 ALDH1A2-IN-1 Chemical Structure
  22. GC68464 ALDH1A3-IN-1 ALDH1A3-IN-1 Chemical Structure
  23. GC68462 ALDH1A3-IN-2 ALDH1A3-IN-2 Chemical Structure
  24. GC64618 ALDH1A3-IN-3 ALDH1A3-IN-3 (compound 16) is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate. ALDH1A3-IN-3 can be used for the research of prostate cancer. ALDH1A3-IN-3 Chemical Structure
  25. GC41390 Aldosterone

    Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance

     Aldosterone Chemical Structure
  26. GC65281 Aleplasinin Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin Chemical Structure
  27. GC65044 Alirocumab (anti-PCSK9) Alirocumab (anti-PCSK9) is a human monoclonal antibody inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9). Alirocumab (anti-PCSK9) Chemical Structure
  28. GC19584 Alkaline Phosphatase

    10-50units/mg protein(37℃,pH 9.8)

     Alkaline Phosphatase Chemical Structure
  29. GC14511 all-trans Retinal converted to retinoic acid in vivo all-trans Retinal Chemical Structure
  30. GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. all-trans Retinoyl β-D-Glucuronide Chemical Structure
  31. GC18539 all-trans-4-hydroxy Retinoic Acid all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. all-trans-4-hydroxy Retinoic Acid Chemical Structure
  32. GC31420 all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid), an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) Chemical Structure
  33. GC61487 all-trans-Anhydro Retinol all-trans-Anhydro Retinol (Anhydrovitamin A) is a metabolite of Vitamin A. all-trans-Anhydro Retinol Chemical Structure
  34. GC60574 Allantoic acid Allantoic acid is a degradative product of uric acid and associated with purine metabolism. Allantoic acid Chemical Structure
  35. GN10492 Allantoin Allantoin Chemical Structure
  36. GC33807 Alloepipregnanolone An Analytical Reference Standard Alloepipregnanolone Chemical Structure
  37. GC15322 Allopurinol Xanthine oxidase inhibitor Allopurinol Chemical Structure
  38. GC35295 Allopurinol riboside A ribonucleoside Allopurinol riboside Chemical Structure
  39. GC38734 Allotetrahydrocortisol Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Allotetrahydrocortisol Chemical Structure
  40. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) Chemical Structure
  41. GC13949 Alogliptin Benzoate A DPP-4 inhibitor Alogliptin Benzoate Chemical Structure
  42. GC35300 Aloin(mixture of A&B) Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin(mixture of A&B) Chemical Structure
  43. GC38885 alpha-D-glucose alpha-D-glucose is an endogenous metabolite. alpha-D-glucose Chemical Structure
  44. GC19750 alpha-L-Rhamnose alpha-L-Rhamnose Chemical Structure
  45. GC17347 Alprostadil Alprostadil (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Alprostadil Chemical Structure
  46. GC18437 Alternariol monomethyl ether Alternariol monomethyl ether, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species. Alternariol monomethyl ether Chemical Structure
  47. GC14785 Alvelestat NE inhibitor Alvelestat Chemical Structure
  48. GC33356 AM-8735 AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM. AM-8735 Chemical Structure
  49. GC42777 Amastatin (hydrochloride) Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). Amastatin (hydrochloride) Chemical Structure
  50. GC48611 Ambroxol-d5 An internal standard for the quantification of ambroxol Ambroxol-d5 Chemical Structure
  51. GC15828 AMG232 AMG232 (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. AMG232 binds to MDM2 with a Kd of 0.045 nM. AMG232 Chemical Structure
  52. GC32149 Aminoacyl tRNA synthetase-IN-1 Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-1 Chemical Structure
  53. GC35320 Aminoadipic acid Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine. Aminoadipic acid Chemical Structure
  54. GC61563 Aminohexylgeldanamycin Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities. Aminohexylgeldanamycin Chemical Structure
  55. GC35321 Aminomalonic acid Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis. Aminomalonic acid Chemical Structure
  56. GC42788 Aminopeptidase N Inhibitor Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). Aminopeptidase N Inhibitor Chemical Structure
  57. GC67997 Aminopeptidase-IN-1 Aminopeptidase-IN-1 Chemical Structure
  58. GC18274 Amiprofos-methyl Amiprofos-methyl (APM) is a phosphoric amide herbicide. Amiprofos-methyl Chemical Structure
  59. GC52059 AMOZ AMOZ Chemical Structure
  60. GC39477 AMP-PCP disodium

    AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90.

     AMP-PCP disodium Chemical Structure
  61. GC14152 Amprenavir (agenerase) A selective HIV protease inhibitor Amprenavir (agenerase) Chemical Structure
  62. GC33484 Ampyrone (4-Aminoantipyrine) Ampyrone (4-Aminoantipyrine) Chemical Structure
  63. GP10057 Amyloid β-Peptide (10-20) (human) Amyloid β-Peptide (10-20) (human) Chemical Structure
  64. GC41211 Anacardic Acid Diene Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic Acid Diene Chemical Structure
  65. GC41531 Anacardic Acid Triene Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic Acid Triene Chemical Structure
  66. GC31341 Anagliptin (SK-0403) Anagliptin (SK-0403) (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively. Anagliptin (SK-0403) Chemical Structure
  67. GC35339 Anandamide An immune modulator in the central nervous system Anandamide Chemical Structure
  68. GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole Anastrozole-d12 Chemical Structure
  69. GC42806 Andrastin A Andrastin A is a meroterpenoid farnesyltransferase inhibitor. Andrastin A Chemical Structure
  70. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  71. GP10077 Angiotensin (1-7)

    Ang-(1-7) (H - Asp - Arg - Val - Tyr - Ile - His - Pro - OH) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively[1].

     Angiotensin (1-7) Chemical Structure
  72. GC61496 Angiotensin (1-7) (acetate) Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin (1-7) (acetate) Chemical Structure
  73. GA20760 Angiotensin A (1-7) Angiotensin A (1-7), a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Angiotensin A (1-7) Chemical Structure
  74. GC35355 Angiotensin III Angiotensin III Chemical Structure
  75. GC35356 Angiotensin III TFA Angiotensin III TFA Chemical Structure
  76. GC32604 Angiotensinogen (1-14), human Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen (1-14), human Chemical Structure
  77. GC61511 Angstrom6 Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling. Angstrom6 Chemical Structure
  78. GC14937 Anguizole Anguizole Chemical Structure
  79. GC30722 Anserine Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine Chemical Structure
  80. GC42818 Antimycin A1

    Antimycin A, an antibiotic produced by Streptomyces species that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties, is a mixture of Antimycins A1, A2, A3, and A4.

     Antimycin A1 Chemical Structure
  81. GC18621 Antimycin A2 Antimycin A2 is an active component of the antimycin A antibiotic complex. Antimycin A2 Chemical Structure
  82. GC42820 Antimycin A4 Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1, antimycin A2, and antimycin A3. Antimycin A4 Chemical Structure
  83. GC35361 Antineoplaston A10 Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Antineoplaston A10 Chemical Structure
  84. GC40032 Antipain (hydrochloride) Antipain (hydrochloride) is a protease inhibitor isolated from Actinomycetes. Antipain (hydrochloride) Chemical Structure
  85. GC42821 AP219 AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. AP219 Chemical Structure
  86. GC42823 AP39 AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. AP39 Chemical Structure
  87. GC65035 Apatorsen Apatorsen?is?an?antisense?oligonucleotide?designed?to?bind?to?Hsp27?mRNA,?resulting?in?the?inhibition of?the?production?of?Hsp27?protein. Apatorsen Chemical Structure
  88. GC35367 APG-115 APG-115 (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. APG-115 blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner. APG-115 Chemical Structure
  89. GC35369 Apigenin-7-glucuronide Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. Apigenin-7-glucuronide Chemical Structure
  90. GC13130 Apixaban An inhibitor of Factor Xa Apixaban Chemical Structure
  91. GC62845 Apoatropine hydrochloride Apoatropine hydrochloride Chemical Structure
  92. GC14209 Apoptosis Activator 2 An activator of caspases Apoptosis Activator 2 Chemical Structure
  93. GC10160 Apoptosis Inhibitor A cell-permeable inhibitor of caspase-3 activation Apoptosis Inhibitor Chemical Structure
  94. GC14411 Apoptozole inhibitor of heat shock protein 70 (Hsp70) Apoptozole Chemical Structure
  95. GC49843 Aposcopolamine A tropane alkaloid and an active metabolite of scopolamine Aposcopolamine Chemical Structure
  96. GC60591 Apovincaminic acid hydrochloride salt Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt Chemical Structure
  97. GC35377 Apratastat An inhibitor of ADAM17 and MMPs Apratastat Chemical Structure
  98. GC12900 Aprotinin

    A serine protease inhibitor

     Aprotinin Chemical Structure
  99. GC45385 Ara-G   Ara-G Chemical Structure
  100. GC61691 Arabinose Arabinose is an endogenous metabolite. Arabinose Chemical Structure
  101. GC35379 Arachidic acid A longchain saturated fatty acid Arachidic acid Chemical Structure

Items 801 to 900 of 3514 total

per page
  2. 7
  3. 8
  4. 9
  5. 10
  6. 11

Set Descending Direction