Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Targets for Neuroscience
- 5-HT Receptor(510)
- AChR(57)
- AChE(103)
- Alzheimer(88)
- Amyloid β(130)
- BACE(5)
- CGRP (29)
- COX(286)
- DAPK(5)
- Dopamine Receptor(295)
- GABA Receptor(225)
- Gap Junction(15)
- GluR(121)
- Histamine(2)
- Histamine Receptor(229)
- mPEGS-1(4)
- Muscarinic Receptor(42)
- Neuroscience Peptides(47)
- Nicotinic Receptor(65)
- P2 Receptor(2)
- P2X7 receptor(3)
- SSRIs(7)
- Substance P/NK1 Receptor(20)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(132)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(58)
- iGluR(130)
- nAChR(60)
- Beta-secretase(24)
- CaMK(28)
- Dopamine Transporter(17)
- Monoamine Oxidase(78)
- Serotonin Transporter(54)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Products for Neuroscience
- Cat.No. Product Name Information
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GC34064
Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride)
Aminooxyacetate
Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. - GC16052 Aminopotentidine H2 antagonist
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GC12610
Amisulpride
DAN 2163
Dopamine D2/D3 receptor antagonist - GC35323 Amisulpride hydrochloride Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
- GC52004 Amisulpride N-oxide A degradation product of amisulpride
- GC46843 Amisulpride-d5 An internal standard for the quantification of amisulpride
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GC30981
Amitifadine hydrochloride (DOV-21947 hydrochloride)
DOV-21947 hydrochloride; EB-1010 hydrochloride
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. -
GC33983
Amitraz (BTS-27419)
NSC 324552
Amitraz (BTS-27419) is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis. -
GC25060
Amitriptyline
MK-230, N-750, Ro41575
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. -
GC13723
Amitriptyline HCl
NIH 10794, Ro 4-1575
Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. -
GC49336
AMK (hydrochloride)
N-γ-acetyl-5-Methoxykynurenamine, N1-acetyl-5-Methoxykynuramine
An active metabolite of melatonin - GC11287 AMN 082 dihydrochloride AMN 082 dihydrochloride, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain.
- GC68438 AMPA receptor modulator-3
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GC14104
Ampiroxicam
CP 65,703
COX inhibitor - GC33484 Ampyrone (4-Aminoantipyrine)
- GC12472 Amthamine dihydrobromide H2 agonist
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GC42796
Amylin (human) (trifluoroacetate salt)
IAPP (human), Islet Amyloid Polypeptide (human)
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. - GC35334 Amyloid β Peptide (42-1)(human) Amyloid β Peptide (42-1)(human) is the inactive form of Amyloid β Peptide (1-42).
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GA20733
Amyloid β-Protein (1-42)
Compared to the inner salt, the HCl salt of Aβ42 aggregates more readily at pH 7.4.
- GA20730 Amyloid β-Protein (1-42) (HFIP-treated) H-7442 was obtained by dissolving Amyloid β-Protein (1-42) (H-1368) in HFIP, aliquoting, and removing the solvent as described in the literature.
- GA20736 Amyloid β-Protein (1-43) Amyloid β-Protein (1-43) is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42.
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GP10099
amyloid A protein fragment [Homo sapiens]
H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH
Apolipoproteins related to HDL in plasma -
GP10118
Amyloid Beta-Peptide (1-40) (human)
Amyloid β-Peptide (1-40) (human), (C194H295N53O58S1), a peptide with the sequence H2N-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH, MW= 4329.8. Amyloid beta (Aβ or Abeta) is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein.
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GP10049
Amyloid Beta-Peptide (12-28) (human)
Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)).
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GP10082
Amyloid Beta-peptide (25-35) (human)
Amyloid beta-peptide (25-35) (human) is an fragment of Alzheimer's Amyloid beta peptide which has neurotoxic effects.
- GC33160 amyloid P-IN-1 amyloid P-IN-1 is used in the research of diseases or disorders wherein depletion of serum amyloid P component (SAP), including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.
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GP10046
Amyloid Precursor C-Terminal Peptide
H2N-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH
For beta amyloid generation
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GP10057
Amyloid β-Peptide (10-20) (human)
Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe
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GP10094
Amyloid β-peptide (10-35), amide
H2N-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2
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GP10097
Amyloid β-Protein (1-15)
H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH
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GC46851
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
Aβ (1-42), Aβ42
A 42-amino acid protein fragment of amyloid-β -
GC42801
Amyloid-β (1-8) Peptide
Aβ (1-8)
Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide . -
GC42802
Amyloid-β (1-8, A2V) Peptide
Aβ (1-8, A2V), Aβ (1-8) mutant, Amyloid-β (1-8) dominant negative
Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). -
GC42803
Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
Aβ (25-35)
Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. - GC30866 Anabasine ((S)-Anabasine) Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) is an alkaloid that found as a minor component in tobacco (Nicotiana).
- GC39254 Anatabine dicitrate Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.
- GN10685 Anemarsaponin B
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GC42809
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)
Angiotensin IV (human, rat, mouse)
Angiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.
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GC46856
Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)
Angiotensin (5-8)
An endogenous angiotensin II fragment
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GC49419
Aniline-d5
Aminobenzene-d5, Phenyl-d5 amine, Benzenamine-d5
An internal standard for the quantification of aniline -
GC17695
Aniracetam
Memodrin, Ro 13-5057, Sarpul
Nootropic drug for senile dementia - GC14008 Anpirtoline hydrochloride 5-HT1B receptor agonist
- GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.
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GC13899
Antazoline HCl
2-(N-Benzylanilinomethyl)-2-imidazoline Hydrochloride
Antazoline HCl is a 1st generation antihistamine with also anticholinergic properties used to relieve nasal congestion and in eye drops. -
GC46858
Anthirine
Antirhine
An alkaloid with analgesic activity - GC46859 Antide (acetate) A GnRHR antagonist
- GC31141 Antihistamine-1 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
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GC49209
Antisauvagine-30 (trifluoroacetate salt)
AS30, D-FHLLRKMIEIEKNEKEKNNAANNRLLLDTI-NH2, D-Phe11,His12Svg11-40, aSVG, aSvg-30
A peptide CRF2 antagonist - GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
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GC30911
Apimostinel (NRX-1074)
NRX-1074; AGN-241660
Apimostinel (NRX-1074) (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist. -
GC15200
Aprepitant
Emend, L754,030, MK-869, ONO7436
Substance P (SP) inhibitor - GC46868 Aprepitant-d4 An internal standard for the quantification of aprepitant
- GC13340 AQ-RA 741 M2 antagonist,selective and high affinity
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GC31291
AR-A 2 (AR-A 000002)
AR-A 000002
AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety. - GC11060 AR-R 17779 hydrochloride Selective agonist of α7 nAChRs
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GC49473
ARA 290 (acetate)
Cibinetide, PHBSP, Pyroglutamate HBSP, Pyroglutamate Helix B Surface Peptide
A derivative of EPO -
GC52514
Arachidonic Acid-d11 ethyl ester
C20:4 (cis-5,8,11,14)-d11 ethyl ester, Ethyl Arachidonate-d11, Ethyl (cis-5,8,11,14)-eicosatetraenoate-d11
An internal standard for the quantification of arachidonic acid ethyl ester -
GC46877
Arachidonoyl Glycine-d8
NAGlyd8, NArachidonyl Glycined8
An internal standard for the quantification of arachidonoyl glycine -
GC63654
Aramisulpride
R-(+)-Amisulpride
Aramisulpride is a dopamine D2 receptor and serotonin receptor antagonist used for the research of metabolic disorders. - GC35381 Arborine Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure.
- GC60596 Arecaidine Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor.
- GC11415 Arecaidine but-2-ynyl ester tosylate mAChR M2 agonist
- GC63879 Arecaidine hydrochloride Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor.
- GC16504 Arecaidine propargyl ester tosylate muscarinic receptor agonist
- GC13240 Arecoline Muscarinic acetylcholine receptors agonist
- GC10264 Arecoline hydrobromide muscarinic acetylcholine receptor agonist
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GC42852
Arginine Vasotocin (trifluoroacetate salt)
Arg8-Vasotocin, AVT
Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X. -
GC52332
Arimoclomol
BRX-220
A co-inducer of heat shock proteins -
GC10117
Aripiprazole
OPC 31, OPC 14597
5-HT receptor partial agonist -
GC35386
Aripiprazole D8
OPC-14597 D8
- GC52168 Aripiprazole N,N-dioxide
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GC52024
Aripiprazole N-oxide
Aripiprazole N1-Oxide
A metabolite of aripiprazole -
GC68687
Aripiprazole-d8
Aripiprazole-d8 is the deuterated form of Aripiprazole.
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GC11309
ARN2966
2-PMAP
APP expression modulator
- GC17525 AS 19 Potent 5-HT7 agonist
- GC17776 Asaraldehyde COX inhibitor
- GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor
- GC14518 Asenapine hydrochloride
- GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.
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GC15438
Asoxime (chloride)
HI-6
Asoxime (chloride) (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. -
GC40848
Aspalatone
Acetylsalicylic Acid Matol ester
Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. -
GC15706
Aspirin (Acetylsalicylic acid)
Acetylsalicylic Acid, NSC 27223, NSC 406186
A non-selective, irreversible COX inhibitor - GC63683 Aspirin-d3
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GC42859
Aspirin-d4
Acetylsalicylic Acid-d4
Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS. -
GC16945
Astemizole
NSC 329963
anti-histamine compound, potent - GC16807 AT 1015 Long-acting 5-HT2A antagonist
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GC31538
AT-1002
AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.
- GC34477 AT-1002 TFA AT-1002 TFA, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.
- GC42865 AT-121 AT-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively).
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GC39554
AT2 receptor agonist C21
Compound 21
An AT2 receptor agonist -
GC18133
ATB-346
ATB-346
ATB-346 (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). -
GC65596
Atogepant
MK-8031; AGN-241689
Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. - GC38497 ATPA
- GC46891 ATPA (hydrate) An agonist of GluR5
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GC15667
Atracurium Besylate
BW 33A, Tracrium, Wellcome 33A74
Neuromuscular blocking agent -
GC16526
Atropine
Tropine
MAChRs antagonist -
GC35427
Atropine methyl bromide
NSC 61810
A muscarinic acetylcholine receptor antagonist - GC35428 Atropine sulfate Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively.
- GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
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GC46895
Aurintricarboxylic Acid (ammonium salt)
ATA
A protein synthesis inhibitor with diverse biological activities