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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC35761 CX-5461 dihydrochloride CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM). CX-5461 dihydrochloride Chemical Structure
  3. GC32700 CYC065 CYC065 (CYC065) is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50s of 5 and 26 nM, respectively. CYC065 Chemical Structure
  4. GC34309 Cycloguanil D6 (Chlorguanide triazine D6) Cycloguanil D6 (Chlorguanide triazine D6) Chemical Structure
  5. GC35781 Cycloguanil D6 Nitrate Cycloguanil D6 Nitrate is the deuterium labeled Cycloguanil, which is a dihydrofolate reductase inhibitor. Cycloguanil D6 Nitrate Chemical Structure
  6. GC11145 Cyclophosphamide Cyclophosphamide is a frequently used chemotherapy, often in combination with other chemotherapy types, for the treatment of breast cancer, malignant lymphomas, multiple myeloma, and neuroblastoma Cyclophosphamide Chemical Structure
  7. GC14077 Cyclophosphamide monohydrate An alkylating agent Cyclophosphamide monohydrate Chemical Structure
  8. GC47148 Cyclophosphamide-d4 An internal standard for the quantification of cyclophosphamide Cyclophosphamide-d4 Chemical Structure
  9. GC43351 Cylindrospermopsin

    Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease.

     Cylindrospermopsin Chemical Structure
  10. GC13070 Cytarabine Cytotoxic agent, blocks DNA synthesis Cytarabine Chemical Structure
  11. GC49863 Cytarabine 5′-monophosphate An active metabolite of cytarabine Cytarabine 5′-monophosphate Chemical Structure
  12. GC14961 Cytarabine hydrochloride DNA synthsis inhibitor Cytarabine hydrochloride Chemical Structure
  13. GC13729 Cytidine pyrimidine nucleoside Cytidine Chemical Structure
  14. GC49104 Cytidine 3’-monophosphate A ribonucleotide Cytidine 3’-monophosphate Chemical Structure
  15. GC47162 Cytidine 5'-triphosphate (sodium salt hydrate) A pyrimidine nucleoside triphosphate Cytidine 5'-triphosphate (sodium salt hydrate) Chemical Structure
  16. GC49526 Cytidine-d2 An internal standard for the quantification of cytidine Cytidine-d2 Chemical Structure
  17. GC49464 Cytosine-d2 An internal standard for the quantification of cytosine Cytosine-d2 Chemical Structure
  18. GC39149 D-I03 D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 ?M. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 ?M and 8 ?M, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin. D-I03 Chemical Structure
  19. GC47276 D-threo-PPMP (hydrochloride) A GlyCer synthetase inhibitor D-threo-PPMP (hydrochloride) Chemical Structure
  20. GC13202 D4476 Inhibitor of CK1 and ALK5 D4476 Chemical Structure
  21. GC14485 Dacarbazine Antineoplastic( malignant melanoma and sarcomas) Dacarbazine Chemical Structure
  22. GC47167 Dacarbazine-d6 An internal standard for the quantification of dacarbazine Dacarbazine-d6 Chemical Structure
  23. GC63419 Dalpiciclib Dalpiciclib (SHR-6390) is an orally active and highly selective inhibitor of CDK4 and 6 with IC50 values of 12.4?nM and 9.9?nM, respectively. Dalpiciclib shows antitumor activity against breast cancer and esophageal squamous cell carcinoma. Dalpiciclib Chemical Structure
  24. GC65369 Dalpiciclib hydrochloride Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC50 values of 12.4?nM and 9.9?nM, respectively. Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal squamous cell carcinoma. Dalpiciclib hydrochloride Chemical Structure
  25. GC10214 Daptomycin Calcium-dependent antibiotic Daptomycin Chemical Structure
  26. GC33124 Datelliptium chloride Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities. Datelliptium chloride Chemical Structure
  27. GC11175 Daun02 Daun02 Chemical Structure
  28. GC12828 Daunorubicin

    DNA topoisomerase II inhibitor

     Daunorubicin Chemical Structure
  29. GC10354 Daunorubicin HCl Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin HCl Chemical Structure
  30. GC33148 DC-05 DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively. DC-05 Chemical Structure
  31. GC67886 DC-U4106 DC-U4106 Chemical Structure
  32. GC32872 DC_517 DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 Chemical Structure
  33. GC67970 DD-03-156 DD-03-156 Chemical Structure
  34. GC65440 ddCTP trisodium ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium Chemical Structure
  35. GC65295 ddGTP trisodium ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium Chemical Structure
  36. GC64020 ddTTP ddTTP is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddTTP Chemical Structure
  37. GC18666 Debromohymenialdisine Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine Chemical Structure
  38. GC17412 Deferasirox Fe3+ chelate Deferasirox Fe3+ chelate Chemical Structure
  39. GC35829 Dehydroaltenusin Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 ?M) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki=0.18 ?M). Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo. Dehydroaltenusin Chemical Structure
  40. GC34123 Deoxycytidine triphosphate (dCTP) Deoxycytidine triphosphate (dCTP) (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate (dCTP) Chemical Structure
  41. GC12634 Deoxyguanosine 5-triphosphate Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine 5-triphosphate Chemical Structure
  42. GC33494 Deoxypseudouridine Deoxypseudouridine is a nucleoside analog. Deoxypseudouridine Chemical Structure
  43. GC62925 Deoxythymidine-5’-triphosphate trisodium salt Deoxythymidine-5'-triphosphate (dTTP) trisodium is one of the four nucleoside triphosphates used in the synthesis of DNA. Deoxythymidine-5’-triphosphate trisodium salt Chemical Structure
  44. GC49225 Deoxyuridine 5′-monophosphate (sodium salt) Deoxyuridine 5′-monophosphate (sodium salt) is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). Deoxyuridine 5′-monophosphate (sodium salt) Chemical Structure
  45. GC38482 Desmethylglycitein Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities.Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. Desmethylglycitein Chemical Structure
  46. GC65617 DHFR-IN-3 DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively. DHFR-IN-3 Chemical Structure
  47. GC60763 DHODH-IN-11 DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. DHODH-IN-11 Chemical Structure
  48. GC39234 DHODH-IN-2 DHODH-IN-2 Chemical Structure
  49. GC39374 DHODH-IN-5 DHODH-IN-5 Chemical Structure
  50. GC32343 Diaveridine (EGIS-5645) Diaveridine (EGIS-5645) (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. Diaveridine (EGIS-5645) Chemical Structure
  51. GC49022 Didanosine-d2 An internal standard for the quantification of didanosine Didanosine-d2 Chemical Structure
  52. GC39808 Didesmethylrocaglamide Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity. Didesmethylrocaglamide Chemical Structure
  53. GC12266 Didox synthetic antioxidant Didox Chemical Structure
  54. GC41112 Dihydroxy Melphalan Dihydroxy melphalan is an inactive degradation product of melphalan. Dihydroxy Melphalan Chemical Structure
  55. GC17648 Dinaciclib(SCH727965) Dinaciclib(SCH727965) (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively. Dinaciclib(SCH727965) Chemical Structure
  56. GC31684 Dithranol (Anthralin) Dithranol (Anthralin) (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol (Anthralin) Chemical Structure
  57. GC19495 DL-Folinic Acid (calcium salt) DL-Folinic Acid (calcium salt) (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. DL-Folinic Acid (calcium salt) Chemical Structure
  58. GC17837 DMAT A cell-permeable inhibitor of CK2 DMAT Chemical Structure
  59. GC16582 DMNB DNA-dependent protein kinase (DNA-PK) inhibitor DMNB Chemical Structure
  60. GC66210 DMT-2'O-MOE-rG(ib) Phosphoramidite DMT-2'O-MOE-rG(ib) Phosphoramidite (1g), belonging to the amide family of trivalent phosphate H3PO3, is a derivative of nucleotides and guanosine and can be used in the stereochemical synthesis of phosphorothioate oligonucleotides. DMT-2'O-MOE-rG(ib) Phosphoramidite Chemical Structure
  61. GC61708 Dmt-2'fluoro-da(bz) amidite Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite Chemical Structure
  62. GC62150 DMT-dC(ac) Phosphoramidite DMT-dC(ac) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis. DMT-dC(ac) Phosphoramidite Chemical Structure
  63. GC61916 DMT-dC(bz) Phosphoramidite DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA. DMT-dC(bz) Phosphoramidite Chemical Structure
  64. GC62538 DMT-dG(dmf) Phosphoramidite DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides DMT-dG(dmf) Phosphoramidite Chemical Structure
  65. GC61912 DMT-dG(ib) Phosphoramidite DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA. DMT-dG(ib) Phosphoramidite Chemical Structure
  66. GC61913 DMT-dU-CE Phosphoramidite DMT-dU-CE Phosphoramidite is a nucleoside molecule that can be used in DNA synthesis and DNA sequencing. DMT-dU-CE Phosphoramidite Chemical Structure
  67. GC66711 DMTr-LNA-5MeU-3-CED-phosphoramidite DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative. DMTr-LNA-5MeU-3-CED-phosphoramidite Chemical Structure
  68. GC35888 DNA31 DNA31 is a potent RNA polymerase inhibitor. DNA31 Chemical Structure
  69. GC65546 DNMT3A-IN-1 DNMT3A-IN-1 is a potent and selective DNMT3A inhibitor. DNMT3A-IN-1 Chemical Structure
  70. GC35893 Domatinostat Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Domatinostat Chemical Structure
  71. GC11099 Doxifluridine oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) Doxifluridine Chemical Structure
  72. GC15250 DOXO-EMCH Prodrug of doxorubicin DOXO-EMCH Chemical Structure
  73. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  74. GC15399 Dp44mT iron chelator and anticancer agent Dp44mT Chemical Structure
  75. GC15294 DPQ DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. DPQ Chemical Structure
  76. GC38774 DRF-1042 DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. DRF-1042 Chemical Structure
  77. GC64715 DS96432529 DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition. DS96432529 Chemical Structure
  78. GC38202 DTP3 TFA DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway. DTP3 TFA Chemical Structure
  79. GC35906 DUBs-IN-1 DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8. DUBs-IN-1 Chemical Structure
  80. GC17125 DUBs-IN-2 DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. DUBs-IN-2 Chemical Structure
  81. GC10356 DUBs-IN-3 DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8. DUBs-IN-3 Chemical Structure
  82. GC35907 Duocarmycin Duocarmycin, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin Chemical Structure
  83. GC38080 Duocarmycin Analog Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog Chemical Structure
  84. GC35909 Duocarmycin GA Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines. Duocarmycin GA Chemical Structure
  85. GC35910 Duocarmycin MA Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines. Duocarmycin MA Chemical Structure
  86. GC35911 Duocarmycin MB Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB Chemical Structure
  87. GC32187 Duocarmycin TM Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. Duocarmycin TM Chemical Structure
  88. GC32926 Dxd (Exatecan derivative) Dxd (Exatecan derivative) (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd (Exatecan derivative) Chemical Structure
  89. GC62212 Dxd-D5 Dxd-d5 (Exatecan-d5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) . Dxd-D5 Chemical Structure
  90. GC10620 E3330 E3330 is a small-molecule inhibitor of apurinic-apyrimidinic endonuclease/redox effector factor (APE1/Ref-1) redox domain function (IC50, 50 µmol/L). E3330 Chemical Structure
  91. GC64209 E7016 E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent. E7016 Chemical Structure
  92. GC18172 E7449 E7449 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 and 1.2 nM, respectively) as well as tankyrase (TNKS) 1/2 (IC50s = 50-100 nM). E7449 Chemical Structure
  93. GC32401 EC0489 EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-drug conjugate (SMDC). EC0489 Chemical Structure
  94. GC64682 Eciruciclib Eciruciclib is an antineoplastic and potent cyclin dependent kinase (CDK) inhibitor. Eciruciclib Chemical Structure
  95. GC19129 EDO-S101 EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. EDO-S101 Chemical Structure
  96. GC33128 Edotecarin (J 107088) Edotecarin (J 107088) is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. Edotecarin (J 107088) Chemical Structure
  97. GC62607 EFdA-TP tetraammonium EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium Chemical Structure
  98. GC38330 EHT 5372 EHT 5372 Chemical Structure
  99. GC18620 EIDD-1931

    A ribonucleoside analog with antiviral activity

     EIDD-1931 Chemical Structure
  100. GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. eIF4A3-IN-1 Chemical Structure
  101. GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. eIF4A3-IN-2 Chemical Structure

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