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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC65234 eIF4A3-IN-8 4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth. eIF4A3-IN-8 Chemical Structure
  3. GC64191 Elevenostat Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235??M). Anti-multiple myeloma (MM) activity. Elevenostat Chemical Structure
  4. GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. Elimusertib (BAY-1895344) hydrochloride Chemical Structure
  5. GC62108 Elimusertib hydrochloride Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and lymphomas. Elimusertib hydrochloride Chemical Structure
  6. GC15548 Ellagic acid Casein kinase 2 (CK2) inhibitor Ellagic acid Chemical Structure
  7. GC15305 Ellipticine DNA topoisomerase II inhibitor Ellipticine Chemical Structure
  8. GC35973 Ellipticine hydrochloride Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Ellipticine hydrochloride Chemical Structure
  9. GC16044 Emodin Natural CK2 inhibitor and ER agonist Emodin Chemical Structure
  10. GC11654 Enocitabine nucleoside analog used as chemotherapy Enocitabine Chemical Structure
  11. GC34083 EOAI3402143 EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. EOAI3402143 Chemical Structure
  12. GC43618 Epiblastin A

    Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively).

     Epiblastin A Chemical Structure
  13. GC35997 Epirubicin Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity. Epirubicin Chemical Structure
  14. GC35998 Episilvestrol Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol Chemical Structure
  15. GC61513 Epitalon TFA Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA Chemical Structure
  16. GC38102 Epithalon Epithalon is an anti-aging agent and a telomerase activator. Epithalon Chemical Structure
  17. GC38103 Epithalon TFA

    Epitalon TFA is an anti-aging agent and a telomerase activator.

     Epithalon TFA Chemical Structure
  18. GC52516 Erbstatin A tyrosine kinase inhibitor Erbstatin Chemical Structure
  19. GC48372 Erythromycin 2'-Propionate An antibiotic Erythromycin 2'-Propionate Chemical Structure
  20. GC52303 Ethyl Mycophenolate A potential impurity found in commercial preparations of mycophenolate mofetil Ethyl Mycophenolate Chemical Structure
  21. GC34112 Ethynylcytidine (ECyD) Ethynylcytidine (ECyD) (ECyD), a nucleoside analog and a potent inhibitor of RNA synthesis, inhibits RNA polymerases I, II and II. Ethynylcytidine (ECyD) has robust antitumor activity in a wide range of models of cancer. Ethynylcytidine (ECyD) Chemical Structure
  22. GC15617 Etoposide

    Topo II inhibitor

     Etoposide Chemical Structure
  23. GC60826 Etoposide phosphate Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor?to prevent re-ligation of DNA strands. Etoposide phosphate Chemical Structure
  24. GC10196 ETP-46464 ATR inhibitor,potent and selective ETP-46464 Chemical Structure
  25. GC38392 Euscaphic acid Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM. Euscaphic acid induces apoptosis. Euscaphic acid Chemical Structure
  26. GC33108 Exatecan (DX-8951) Exatecan (DX-8951) (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Exatecan (DX-8951) Chemical Structure
  27. GC62184 Exatecan D5 mesylate Exatecan D5 mesylate Chemical Structure
  28. GC19148 Exatecan Mesylate Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 uM (0.975 ug/mL), and can be used in cancer research. Exatecan Mesylate Chemical Structure
  29. GC62968 Fanotaprim Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim Chemical Structure
  30. GC46146 FD-211 A δ lactone with anticancer activity FD-211 Chemical Structure
  31. GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases Flavopiridol Chemical Structure
  32. GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective Flavopiridol hydrochloride Chemical Structure
  33. GC18014 Floxuridine Antineoplastic antimetabolite Floxuridine Chemical Structure
  34. GC14144 Fludarabine DNA synthsis inhibitor Fludarabine Chemical Structure
  35. GC15134 Fludarabine Phosphate (Fludara) Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. Fludarabine Phosphate (Fludara) Chemical Structure
  36. GC66430 Fludarabine triphosphate trisodium

    Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine, is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.

     Fludarabine triphosphate trisodium Chemical Structure
  37. GC16455 Flumequine DNA topoisomerase II inhibitor，synthetic chemotherapeutic antibiotic Flumequine Chemical Structure
  38. GC49134 Flumequine-13C3 An internal standard for the quantification of flumequine Flumequine-13C3 Chemical Structure
  39. GC49455 Fluorescein-12-dATP A fluorescently labeled form of dATP Fluorescein-12-dATP Chemical Structure
  40. GC49746 Fluorescein-12-dCTP A fluorescently labeled form of dCTP Fluorescein-12-dCTP Chemical Structure
  41. GC49456 Fluorescein-12-dGTP A fluorescently labeled form of dGTP Fluorescein-12-dGTP Chemical Structure
  42. GC14466 Fluorouracil (Adrucil)

    A prodrug form of FdUMP

     Fluorouracil (Adrucil) Chemical Structure
  43. GC36062 FMF-04-159-2 FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 Chemical Structure
  44. GC50719 FMF-04-159-R FMF-04-159-R Chemical Structure
  45. GC33049 FN-1501 FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. FN-1501 Chemical Structure
  46. GN10306 Folic acid Folic acid Chemical Structure
  47. GC63952 Folic Acid-d2 Folic Acid-d2 is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis. Folic Acid-d2 Chemical Structure
  48. GC14331 Folinic acid NULL Folinic acid Chemical Structure
  49. GC49126 Folitixorin A reduced form of folate and cofactor for thymidylate synthetase Folitixorin Chemical Structure
  50. GC33029 Forodesine (BCX-1777 freebase) Forodesine (BCX-1777 freebase) (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine (BCX-1777 freebase) is a potent human lymphocyte proliferation inhibitor. Forodesine (BCX-1777 freebase) could induce apoptosis in leukemic cells by increasing the dGTP levels. Forodesine (BCX-1777 freebase) Chemical Structure
  51. GC32708 Forodesine hydrochloride (BCX-1777) Forodesine hydrochloride (BCX-1777) (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride (BCX-1777) is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride (BCX-1777) could induce apoptosis in leukemic cells by increasing the dGTP levels. Forodesine hydrochloride (BCX-1777) Chemical Structure
  52. GC14885 Foscarnet Sodium Reverse transcriptase inhibitor Foscarnet Sodium Chemical Structure
  53. GC36071 Fosteabine Fosteabine is an oral and prodrug analogue of cytarabine which is resistant to deoxycytidine deaminase. Fosteabine Chemical Structure
  54. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 Chemical Structure
  55. GC13831 FT-207 (NSC 148958) FT-207 (NSC 148958) (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. FT-207 (NSC 148958) Chemical Structure
  56. GC62979 FT206 FT206 is an inhibitor of carboxamides as ubiquitin-specific protrase extracted from patent WO 2020033707 A1, example 11-1. FT206 Chemical Structure
  57. GC67915 FT3967385 FT3967385 Chemical Structure
  58. GC32786 FT671 FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM. FT671 Chemical Structure
  59. GC69134 FT709

    FT709 is an effective selective inhibitor of USP9X with an IC50 value of 82 nM. USP9X is involved in centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemical sensitization and circadian rhythms.

     FT709 Chemical Structure
  60. GC32917 FT827 FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor (Ki=4.2 ?M). FT827 binds to the USP7 catalytic domain (USP7CD; residues 208-560) with an apparent Kd value of 7.8 ?M. FT827 Chemical Structure
  61. GC65206 FT895 FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. FT895 Chemical Structure
  62. GC13541 G007-LK tankyrase 1/2 inhibitor G007-LK Chemical Structure
  63. GC43726 Gallotannin

    Gallotannin is a polyphenol of gallic acid that has been found in various plants and has antioxidant, anti-inflammatory, antiviral, and antiproliferative biological activities.

     Gallotannin Chemical Structure
  64. GC60865 Ganciclovir sodium Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium Chemical Structure
  65. GN10696 Garcinone C Garcinone C Chemical Structure
  66. GC14376 Gatifloxacin Fluoroquinolone antibiotic,inhibits bacterial TOPO II Gatifloxacin Chemical Structure
  67. GC33094 GC7 Sulfate GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. GC7 Sulfate Chemical Structure
  68. GC32739 GCN2iB GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. GCN2iB Chemical Structure
  69. GC62986 GDC-0425 GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies. GDC-0425 Chemical Structure
  70. GC32885 GDC-0575 (ARRY-575, RG7741) GDC-0575 (ARRY-575, RG7741) (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2nM. GDC-0575 (ARRY-575, RG7741) Chemical Structure
  71. GC34127 GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) Chemical Structure
  72. GC19542 GeA-69

    GeA-69 is a selective, highly cell permeable allosteric inhibitor

     GeA-69 Chemical Structure
  73. GC16805 Gemcitabine

    An inhibitor of DNA synthesis

     Gemcitabine Chemical Structure
  74. GC36130 Gemcitabine elaidate A prodrug form of gemcitabine Gemcitabine elaidate Chemical Structure
  75. GC63777 Gemcitabine elaidate hydrochloride Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity. Gemcitabine elaidate hydrochloride Chemical Structure
  76. GC14447 Gemcitabine HCl Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. Gemcitabine HCl Chemical Structure
  77. GC14102 Genistein Genistein is an isoflavone belonging to the flavonoid group of compounds and is found in a number of plants. Genistein Chemical Structure
  78. GC15853 Genz-644282 An inhibitor of topoisomerase I Genz-644282 Chemical Structure
  79. GC32088 Gepotidacin (GSK2140944) Gepotidacin (GSK2140944) (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. Gepotidacin (GSK2140944) Chemical Structure
  80. GC64926 GFB-12811 GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 Chemical Structure
  81. GC18840 Gilvocarcin V Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was orignally isolated from the culture broth of S. Gilvocarcin V Chemical Structure
  82. GC60873 Gimatecan Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. Gimatecan Chemical Structure
  83. GC33050 Givinostat (ITF-2357) Givinostat (ITF-2357) (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF-2357) Chemical Structure
  84. GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride) Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride (ITF-2357 hydrochloride) Chemical Structure
  85. GC36153 Glucose-conjugated MGMT inhibitor Glucose-conjugated MGMT inhibitor is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. Glucose-conjugated MGMT inhibitor Chemical Structure
  86. GC30529 GNE-371 GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). GNE-371 Chemical Structure
  87. GC32856 GNE-6640 An inhibitor of USP7 GNE-6640 Chemical Structure
  88. GC32727 GNE-6776 GNE-6776 is a selective and orally bioavailable USP7 inhibitor. GNE-6776 Chemical Structure
  89. GC39172 GRL0617 A SARS-CoV and SARS-CoV-2 PLpro inhibitor GRL0617 Chemical Structure
  90. GC38511 Groenlandicine Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine Chemical Structure
  91. GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. GSK-3 Inhibitor IX (BIO) Chemical Structure
  92. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1 Chemical Structure
  93. GC34354 GSK2643943A GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) . GSK2643943A Chemical Structure
  94. GC32857 GSK2850163 GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. GSK2850163 Chemical Structure
  95. GC34205 GSK2850163 hydrochloride GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. GSK2850163 hydrochloride Chemical Structure
  96. GC18402 GSK3117391 GSK3117391 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1. GSK3117391 Chemical Structure
  97. GC36196 Guadecitabine sodium Guadecitabine is a novel hypomethylating dinucleotide of decitabine and deoxyguanosine that is resistant to degradation by cytidine deaminase. Guadecitabine sodium Chemical Structure
  98. GC16949 Guanine A purine base Guanine Chemical Structure
  99. GC49033 Guanosine 5’-diphosphate (sodium salt hydrate) A purine nucleotide Guanosine 5’-diphosphate (sodium salt hydrate) Chemical Structure
  100. GC43798 Guanylyl Imidodiphosphate (lithium salt) Guanylyl imidodiphosphate (Gpp(NH)p) lithium, a non-hydrolyzable GTP analogue, increases adenylate cyclase activity. Guanylyl Imidodiphosphate (lithium salt) Chemical Structure
  101. GC31650 Halofuginone (RU-19110) Halofuginone (RU-19110) (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone (RU-19110) Chemical Structure

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