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Home >> Signaling Pathways >> Neuroscience

Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC49646 Aurothioglucose (hydrate)

    Gold Thioglucose

     A TrxR inhibitor Aurothioglucose (hydrate) Chemical Structure
  3. GC46897 AUTEN-99

    Autophagy Enhancer-99

     AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 Chemical Structure
  4. GC33683 Autocamtide 2 (Autocamtide II)

    Autocamtide II

     Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 (Autocamtide II) Chemical Structure
  5. GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Autocamtide 2, amide Chemical Structure
  6. GC35432 Autocamtide-2-related inhibitory peptide (TFA) Autocamtide-2-related inhibitory peptide (TFA) Chemical Structure
  7. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide, myristoylated Chemical Structure
  8. GC42877 AUY954 AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). AUY954 Chemical Structure
  9. GC42881 Avermectin B1a aglycone Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a. Avermectin B1a aglycone Chemical Structure
  10. GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). AVN-492 Chemical Structure
  11. GC10974 AWD 131-138

    ELB138, Imepitoin

     AWD 131-138 (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models. AWD 131-138 Chemical Structure
  12. GC42885 AX 048 The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes. AX 048 Chemical Structure
  13. GC49321 AZ-GHS-22 An inverse agonist of GHS-R1a AZ-GHS-22 Chemical Structure
  14. GC16229 Azaperone

    Fluoperidol, NSC 170976

     Dopamine antagonist Azaperone Chemical Structure
  15. GC35443 Azaphen Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. Azaphen Chemical Structure
  16. GC35444 Azaphen dihydrochloride monohydrate Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. Azaphen dihydrochloride monohydrate Chemical Structure
  17. GC15687 Azasetron HCl

    Y-25130

     Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron HCl Chemical Structure
  18. GC14070 Azatadine Histamine and cholinergic inhibitor Azatadine Chemical Structure
  19. GC15776 Azatadine dimaleate Histamine and cholinergic inhibitor Azatadine dimaleate Chemical Structure
  20. GC31010 AZD-6280 AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder. AZD-6280 Chemical Structure
  21. GC31643 AZD1979 AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM. AZD1979 Chemical Structure
  22. GC14130 AZD3839 AZD3839 is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM). AZD3839 shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 can be used for the research of Alzheimer's disease. AZD3839 Chemical Structure
  23. GC15715 AZD3839 BACE1 inhibitor,potent and selective AZD3839 Chemical Structure
  24. GC33879 Azelastine Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine Chemical Structure
  25. GC17297 Azelastine HCl Azelastine HClm, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine HCl Chemical Structure
  26. GC19053 Azeliragon TTP488 is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). Azeliragon Chemical Structure
  27. GC42893 Azumolene (sodium salt)

    EU4093

     Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene (sodium salt) Chemical Structure
  28. GC39187 Azure B Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B Chemical Structure
  29. GC14491 B-HT 920 A potent agonist of D2 receptors B-HT 920 Chemical Structure
  30. GC18580 B355252 A neuroprotective agent B355252 Chemical Structure
  31. GC31260 BACE-IN-1 BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. BACE-IN-1 Chemical Structure
  32. GC31158 BACE1-IN-1 BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. BACE1-IN-1 Chemical Structure
  33. GC35455 BACE1-IN-4 BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. BACE1-IN-4 Chemical Structure
  34. GC52409 BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)

    BAM 8-22, Bovine Adrenal Medulla 8-22

     A neuropeptide and MRGPRX1 agonist BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Chemical Structure
  35. GC52407 BAM-22P (human, mouse, rat, bovine) (trifluoroacetate salt)

    Bovine Adrenal Medullary Docosapeptide, YGGFMRRVGRPEWWMDYQKRYG

     A neuropeptide BAM-22P (human, mouse, rat, bovine) (trifluoroacetate salt) Chemical Structure
  36. GC31990 Bamaluzole Bamaluzole is a GABA receptor agonist extracted from patent WO 2012064642 A1. Bamaluzole Chemical Structure
  37. GC31840 Bamirastine (TAK-427)

    TAK-427

     Bamirastine (TAK-427) inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R) with an IC50 value of 17.3 nM. Bamirastine (TAK-427) Chemical Structure
  38. GC49019 BAN ORL 24 (hydrochloride) A nociceptin receptor antagonist BAN ORL 24 (hydrochloride) Chemical Structure
  39. GC19057 Basmisanil

    RG-1662

     Basmisanil is a highly selective GABAAα5 negative allosteric modulator. Basmisanil Chemical Structure
  40. GC31690 Batefenterol (GSK961081)

    GSK961081, TD-5959

     Batefenterol (GSK961081) (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively. Batefenterol (GSK961081) Chemical Structure
  41. GC35471 Bavisant

    JNJ-31001074

     Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant Chemical Structure
  42. GC35472 Bavisant dihydrochloride

    JNJ-31001074 dihydrochloride

     Bavisant (JNJ-31001074) dihydrochloride is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride Chemical Structure
  43. GC35473 Bavisant dihydrochloride hydrate

    JNJ31001074AAC; JNJ31001074 dihydrochloride hydrate

     Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate Chemical Structure
  44. GC52476 Bax Inhibitor Peptide V5 (trifluoroacetate salt)

    BIP V5, VPMLK

     A Bax inhibitor Bax Inhibitor Peptide V5 (trifluoroacetate salt) Chemical Structure
  45. GC10141 Bay 36-7620 Selective mGlu1 receptor non-competitive antagonist Bay 36-7620 Chemical Structure
  46. GC39344 BAY-1797 A P2X4receptor antagonist BAY-1797 Chemical Structure
  47. GC33723 Becampanel (AMP 397)

    AMP 397

     Becampanel (AMP 397) (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. Becampanel (AMP 397) Chemical Structure
  48. GC33724 Befetupitant (Ro67-5930)

    Ro67-5930

     Befetupitant (Ro67-5930) is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist. Befetupitant (Ro67-5930) Chemical Structure
  49. GC31113 Befiradol (NLX-112) Befiradol (NLX-112) (NLX-112) is a selective 5-HT1A receptor agonist. Befiradol (NLX-112) Chemical Structure
  50. GC60630 Befiradol hydrochloride

    NLX-112 hydrochloride; F 13640 hydrochloride

     Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-HT1A receptor agonist. Befiradol hydrochloride Chemical Structure
  51. GC34304 Befiradol hydrochloride (NLX-112 (hydrochloride)) Befiradol hydrochloride (NLX-112 (hydrochloride)) Chemical Structure
  52. GC12414 Bemegride GABA receptor antagonist Bemegride Chemical Structure
  53. GC31193 Benactyzine hydrochloride Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a Ki of 0.010 mM. Benactyzine hydrochloride Chemical Structure
  54. GC46915 Bendiocarb

    NC 6897, Niomil

     A broad-spectrum carbamate insecticide Bendiocarb Chemical Structure
  55. GC16782 Benocyclidine

    BCP, Benzothiophenylcyclohexylpiperidine, BTCP, GK 13

     dopamine reuptake inhibitor Benocyclidine Chemical Structure
  56. GC49836 Benoxaprofen

    LRCL 3794, NSC 299582

     Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen Chemical Structure
  57. GC35492 Benzamide Derivative 1 Benzamide Derivative 1 is a benzamide derivative from patent EP0213775A1, compound 18. Benzamide Derivative 1 Chemical Structure
  58. GC14339 Benzethonium Chloride Potent inhibitor of nAChRs Benzethonium Chloride Chemical Structure
  59. GC30925 Benzetimide hydrochloride (R4929)

    Dioxatrine, R 4929, Spasmentral

     Benzetimide hydrochloride (R4929) is a muscarinic acetylcholine receptor antagonist. Benzetimide hydrochloride (R4929) Chemical Structure
  60. GC40889 Benzomalvin A

    (-)-Benzomalvin A

     Benzomalvin A is a fungal metabolite produced by Penicillium. Benzomalvin A Chemical Structure
  61. GC42917 Benzomalvin B Benzomalvin B is a fungal metabolite originally isolated from Penicillium. Benzomalvin B Chemical Structure
  62. GC42918 Benzomalvin C Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. Benzomalvin C Chemical Structure
  63. GC42919 Benzonatate

    Benzonatate is a reversible voltage-gated sodium channel blocker.

     Benzonatate Chemical Structure
  64. GC10009 Benzoquinonium dibromide inhibitor of AChR and ganglion Benzoquinonium dibromide Chemical Structure
  65. GC35493 Benzoylgomisin O Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes and anti-inflammatory activity. Benzoylgomisin O Chemical Structure
  66. GC16791 Benztropine mesylate

    NSC 169913

     Dopamine transporter (DAT) inhibitor Benztropine mesylate Chemical Structure
  67. GC31942 Beperidium iodide (SX 810) Beperidium iodide (SX 810) shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93. Beperidium iodide (SX 810) Chemical Structure
  68. GC39479 Bepotastine Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine Chemical Structure
  69. GC14250 Bepotastine Besilate

    Bepotastine besilate, TAU-284

     Non-sedating, selective antagonist of histamine 1 (H1) receptor Bepotastine Besilate Chemical Structure
  70. GC49387 Berberine-d6 (chloride)

    BBR-d6, Umbellatine-d6

     An internal standard for the quantification of berberine Berberine-d6 (chloride) Chemical Structure
  71. GP10083 Beta-Amyloid (1-11)

    H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH

    Beta-Amyloid (1-11) Chemical Structure
  72. GC34232 Beta-Amyloid(1-14),mouse,rat Beta-Amyloid(1-14),mouse,rat Chemical Structure
  73. GP10051 Beta-Lipotropin (1-10), porcine

    H2N-Glu-Leu-Ala-Gly-Ala-Pro-Pro-Glu-Pro-Ala-OH

    Morphine-like substance

     Beta-Lipotropin (1-10), porcine Chemical Structure
  74. GP10101 Beta-Sheet Breaker Peptide iAβ5

    H2N-Leu-Pro-Phe-Phe-Asp-OH

    Beta-Sheet Breaker Peptide iAβ5 Chemical Structure
  75. GC60072 Betahistine Betahistine is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine Chemical Structure
  76. GC10127 Betahistine 2HCl Betahistine 2HCl is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine 2HCl Chemical Structure
  77. GC60641 Betahistine mesylate Betahistine mesylate is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine mesylate Chemical Structure
  78. GC63923 Betahistine-d3 dihydrochloride Betahistine-d3 dihydrochloride Chemical Structure
  79. GC46922 Betamethasone 21-phosphate (sodium salt hydrate) A synthetic glucocorticoid Betamethasone 21-phosphate (sodium salt hydrate) Chemical Structure
  80. GC52329 Betamethasone-d5

    β-Methasone-d5, SCH 4831-d5

     An internal standard for the quantification of betamethasone Betamethasone-d5 Chemical Structure
  81. GC61539 Betazole Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole Chemical Structure
  82. GC25136 Betazole Dihydrochloride

    Ametazole Dihydrochloride, 2-(3-Pyrazolyl)ethanamine Dihydrochloride

     Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function. Betazole Dihydrochloride Chemical Structure
  83. GC14419 Bethanechol chloride

    (±)-Bethanechol, Carbamyl-β-methylcholine chloride, NSC 30783

     Muscarinic receptor agonist Bethanechol chloride Chemical Structure
  84. GC31124 BF 227

    BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

     BF 227 Chemical Structure
  85. GC33750 BF-168 BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42. BF-168 Chemical Structure
  86. GC15092 BGC 20-761 5-HT6 antagonist,selective and high affinity BGC 20-761 Chemical Structure
  87. GC34494 Bifenazate An acaricide Bifenazate Chemical Structure
  88. GC46014 Bifeprunox (mesylate)

    DU 127090

     An atypical antipsychotic Bifeprunox (mesylate) Chemical Structure
  89. GC46930 Bilaid C

    H-L-Tyr-D-Val-L-Val-D-Phe, H-YVVF

     A tetrapeptide -opioid receptor agonist Bilaid C Chemical Structure
  90. GC17643 Bilastine

    F-96221-BM1

     H1 histamine receptor antagonist Bilastine Chemical Structure
  91. GC63318 Bilastine-d6 Bilastine-d6 Chemical Structure
  92. GC12541 Bilobalide A neuroprotective natural product Bilobalide Chemical Structure
  93. GC49300 BIM-46187 (hydrochloride) An inhibitor of heterotrimeric G-protein signaling BIM-46187 (hydrochloride) Chemical Structure
  94. GC14925 BIMU 8 5-HT4 agonist BIMU 8 Chemical Structure
  95. GC12510 BINA

    BINA, MRLSD 230

     BINA (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders. BINA Chemical Structure
  96. GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    Biotin-Aβ (1-42), Biotin-Aβ42

     Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt) Chemical Structure
  97. GC35524 Biperiden Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden Chemical Structure
  98. GC10621 Biperiden HCl

    NSC 84989, NSC 170950

     Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden HCl Chemical Structure
  99. GC49069 Biperiden-d5 An internal standard for the quantification of biperiden Biperiden-d5 Chemical Structure
  100. GC15628 bis(7)-Tacrine

    1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine

     bis(7)-Tacrine is a dimeric AChE inhibitor derived from tacrine. bis(7)-Tacrine Chemical Structure
  101. GC39481 BL-918 An ULK1 activator BL-918 Chemical Structure

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