Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(23)
- Aurora Kinase(17)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(11)
- Haspin(6)
- HMTase(1)
- Kinesin(23)
- Ksp(4)
- Microtubule/Tubulin(219)
- Mps1(15)
- Mitotic(7)
- RAD51(16)
- ROCK(60)
- Rho(13)
- PERK(10)
- PLK(33)
- PTEN(6)
- Wee1(7)
- PAK(20)
- Arp2/3 Complex(8)
- Dynamin(10)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(26)
- G2/S(10)
- Genotoxic Stress(18)
- Inositol Phosphates(18)
- Proteolysis(99)
- Cytoskeleton & Motor Proteins(53)
- Cellular Chaperones(8)
Products for Cell Cycle/Checkpoint
- Cat.No. Product Name Information
-
GC15663
LY2606368
Prexasertib
LY2606368 (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. LY2606368 inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). LY2606368 causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. LY2606368 shows potent anti-tumor activity. -
GC16822
LY2835219
Abemaciclib
LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively. - GC11823 LY2835219 free base A dual inhibitor of Cdk4 and Cdk6
- GC11971 LY2857785 CDK9 inhibitor
-
GC33057
LY3295668 (AK-01)
AK-01
LY3295668 (AK-01) (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. - GC44100 LysoFP-NH2 LysoFP-NH2 is the fluorescent form of the lysosomal turn-on fluorescent probe for carbon monoxide (CO) lysoFP-NO2.
- GC40021 LysoFP-NO2 LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome.
-
GC52358
Malachite Green (chloride)
Basic Green 4, C.I. 4200, C.I. 42000
A triphenylmethane dye -
GC41186
Malformin C
Malformin B1b
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. - GC61400 MAP4343 MAP4343 is the 3-methylether derivative of Pregnenolone.
-
GC62205
Maytansine
Maitansine, NSC 153858
Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. -
GC32895
Maytansinol (Ansamitocin P-0)
Ansamitocin P-0, Antibiotic C-15003P0, NSC 239386
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and induces microtubule disassembly in vitro. - GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor
- GC36560 Mc-MMAD Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. MMAD is a potent tubulin inhibitor. Mc-MMAD is a drug-linker conjugate for ADC.
- GC36561 Mc-MMAE Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC.
-
GC18363
Mca-DEVDAPK(Dnp)-OH
Caspase-3 Fluorogenic Substrate III, CPP32 Fluorogenic Substrate III, 7-Methoxycoumarin-4-acetyl-DEVDAPK(Dnp)-OH, Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH
Mca-DEVDAPK(Dnp)-OH is a fluorogenic substrate for caspase-3. -
GC44132
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2
Matrix Metalloproteinase-14 Fluorogenic Substrate I, Mca-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH2, MMP-14 Fluorogenic Substrate I
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). -
GC34068
McMMAF (Maleimidocaproyl monomethylauristatin F)
Maleimidocaproyl monomethylauristatin F
McMMAF (Maleimidocaproyl monomethylauristatin F) is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor. -
GC10200
Mdivi 1
Mitochondrial Division Inhibitor 1
A mitochondrial division inhibitor
-
GC17649
Mebendazole
NSC 184849,R 17635
broad-spectrum anthelmintic that inhibits intestinal microtubule synthesis -
GC49486
Meglutol-d3
Dicrotalic Acid-d3, 3-hydroxy 3-methyl Glutaric Acid-d3, HMG-d3, 3-methyl-3-Hydroxyglutaric Acid-d3, Medroglutaric Acid-d3, 3-hydroxy-3-Methylglutaric Acid-d3
An internal standard for the quantification of meglutol -
GC47619
Menaquinone 4-d7
MK-4-d7, Vitamin K2(20)-d7
An internal standard for the quantification of menaquinone 4 -
GC19244
Mertansine
DM1 Compound
Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. -
GC16607
Mesalamine
5-ASA
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. - GC61043 Mesalamine impurity P Mesalamine impurity P is an impurity of Mesalamine.
-
GC49065
Metacetamol
3'-Hydroxyacetanilide, AMAP, N-acetyl-m-Aminophenol, N-acetyl-meta-Aminophenol, NSC 3990
A derivative of acetaminophen - GC47645 Methidathion An organophosphate insecticide
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GC47646
Methiocarb
Mercaptodimethur, 4-Methylthio-3,5-dimethylphenyl methylcarbamate, BAY 37344
A carbamate pesticide -
GC47660
Methyl Parathion
BAY 11405
An organophosphate insecticide - GC40036 MHAPC-Chol MHAPC-Chol is a cationic cholesterol.
- GC36608 Microtubule inhibitor 1 Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC50 value of 9-16 nM in cancer cells.
- GC13491 Mirin Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex.
-
GC44200
Mitomycin A
NSC 75986
Mitomycin A is a bacterial metabolite originally isolated from S. -
GC16030
MK-1775
MK1775,MK 1775
MK-1775 (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM. - GC61072 MK-28 MK-28 is a potent and selective PERK activator.
- GC10442 MK-8745 Aurora A inhibitor,potent and selective
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GC16374
MK-8776(SCH-900776)
MK-8776
MK-8776(SCH-900776) (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. MK-8776(SCH-900776) shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively. -
GC65143
MKC-1
Ro-31-7453
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. -
GC14800
ML 141
CID2950007
Cdc42 GTPase inhibitor -
GC14162
ML167
CID 44968231
Clk4 inhibitor,highly selective - GC32785 ML327 ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
- GC10163 MLN0905 Potent PLK1 inhibitor
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GC13096
MLS-573151
MLS000573151
Cdc42 inhibitor - GC64591 MM41 MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM.
- GC15798 MMAD
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GC63461
MMAE-d8
Monomethyl auristatin E-d8; Deuterated labeled MMAE
MMAE-d8 (Monomethyl auristatin E-d8) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
-
GC10034
MMAF
Monomethylauristatin F
Anti-mitotic/anti-tubulin/antineoplastic agent -
GC36633
MMAF Hydrochloride
Monomethylauristatin F hydrochloride
MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. -
GC38397
MMAF sodium
Monomethylauristatin F sodium
MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. - GC63774 MMAF-d8 hydrochloride D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
-
GC44235
MMP Inhibitor I (trifluoroacetate salt)
Abz-GP-DLeu-DAla-NH-OH, FN 439, Matrix Metalloproteinase Inhibitor I
MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). -
GC18218
MMP-3 Inhibitor
Matrix Metalloproteinase-3 Inhibitor
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
-
GC40624
MMP-3 Inhibitor VIII
Matrix Metalloproteinase-3 Inhibitor VIII, Stromelysin-1 Inhibitor VIII
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. -
GC18616
MMP-8 Inhibitor I
Matrix Metalloproteinase-8 Inhibitor I
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. -
GC14929
Monastrol
(±)-Monastrol
Eg5 inhibitor
- GC15592 Moniliformin (sodium salt) induces mitotic arrest at the metaphase stage
-
GC17276
Monomethyl auristatin E
Brentuximab vedotin, MMAE
A potent antimitotic compound
-
GC45744
monoMICAAc
3-N-methylamino-6-Isocyanoacridine
A solvatochromic fluorescent pH probe -
GC15285
MPC 6827 hydrochloride
Verubulin
MPC 6827 hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. MPC 6827 hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. MPC 6827 hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types. - GC10083 MPI-0479605 Mps1 inhibitor,selective and ATP competitive
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GC11292
Mps1-IN-1
Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1
Mps1 kinase inhibitor
- GC50110 Mps1-IN-1 dihydrochloride Selective Mps1 kinase inhibitor
- GC15745 Mps1-IN-2 Mps1 kinase inhibitor
- GC36651 Mps1-IN-3 Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM.
- GC65339 Mps1-IN-3 hydrochloride Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.
- GC40048 MPS1/TTK Inhibitor MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors.
- GC41564 MPT0B014 An inhibitor of tubulin polymerization
- GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.
- GC62657 MRIA9 MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.
-
GC45515
MX1013
Z-Val-Asp-Fluoromethyl Ketone, Z-VD-FMK
- GC66457 MY-875 MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity.
-
GC69516
MY-943
MY-943 is an effective tubulin polymerization and LSD1 inhibitor with anti-cancer activity. MY-943 induces G2/M phase arrest and cell apoptosis, and inhibits cell migration, making it suitable for gastric cancer research.
-
GC38589
MYCi361
NUCC-0196361
MYCi361 (NUCC-0196361) is a MYC inhibitor with the Kd of 3.2 μM for binding to MYC. MYCi361 (NUCC-0196361) suppresses tumor growth and enhances anti-PD1 immunotherapy. - GC38588 MYCi975
-
GC60259
MYCMI-6
NSC354961
MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6?μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5?μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis. - GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc. Mycro 3 could be used for the research of pancreatic cancer.
- GC15773 Myoseverin microtubule-binding molecule
-
GC44260
Myristoyl Coenzyme A (hydrate)
Myristoyl-CoA, Tetradecanoyl Coenzyme A, Tetradecanoyl-CoA
Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid.
- GC45958 Myrothecine A A trichothecene mycotoxin
-
GC49491
N′-Nitrosonornicotine-d4
NNN-d4
An internal standard for the quantification of N’-nitrosonornicotine -
GC49163
N’-Nitrosonornicotine
NNN
An N-nitrosamine and a carcinogen -
GC45667
N-(p-Tosyl)-GPR-pNA (acetate)
N-(p-Tosyl)-Gly-Pro-Arg-p-Nitroanilide, Tos-Gly-Pro-Arg-pNA
A colorimetric thrombin substrate -
GC18445
N-Deacetylcolchicine
NSC 201400
An inhibitor of microtubule polymerization -
GC44343
n-Decyl-β-D-maltoside
n-Decyl-β-D-maltopyranoside, Decyl-β-maltopyranoside, Decyl-β-maltoside, Decylmaltoside
n-Decyl-β-D-maltoside is a nonionic surfactant that is commonly used to solubilize and stabilize membrane proteins. -
GC52007
N-hydroxylamine Dapsone
Dapsone hydroxylamine, DDS-NHOH
An active metabolite of dapsone -
GC49351
N-Nitroso Atenolol
NO-Atenolol
A genotoxic derivative of (±)-atenolol - GC49394 N-Nitroso Fluoxetine A derivative of fluoxetine
- GC49353 N-Nitroso Metoprolol A genotoxic derivative of metoprolol
- GC44430 n-Nonyl-β-D-glucopyranoside n-Nonyl-β-D-glucopyranoside is an anionic alkylglucoside chiral surfactant that is commonly used for the solubilization and crystallization of biological membrane proteins.
-
GC45833
N-Oleoyl-L-phenylalanine
18-1-Phe, C18:1-Phe
An N-acyl amide -
GC47806
N-p-Tosyl-Gly-Pro-Lys-pNA (acetate)
N-p-Tosyl-Gly-Pro-Lys-p-nitroanilide
A colorimetric plasmin substrate -
GC44313
Naphthofluorescein
CCG 8295
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. -
GC12491
Narciclasine
(+)-Lycoricidinol, (+)-Narciclasine
A plant growth regulator with anticancer activity -
GC49204
Nefazodone-d6 (hydrochloride)
BMY-13754-d6; MJ-13754-1-d6
An internal standard for the quantification of nefazodone - GC45523 Nemorosone
- GC10716 Netarsudil (AR-13324) ROCK inhibitor
-
GC12515
NMS-1286937
NMS-P937, Onvansertib, PCM-075
NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM. - GC36752 NMS-P715 An Mps1/TTK inhibitor
-
GC14075
Nocodazole
NSC 238159, Oncodazole, R 17934
A tubulin production inhibitor,anti-neoplastic agent -
GC47803
Noscapine-13C-d3
Narcotine-13C-d3, Opianine-13C-d3
An internal standard for the quantification of noscapine