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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC15663 LY2606368 LY2606368 (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. LY2606368 inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). LY2606368 causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. LY2606368 shows potent anti-tumor activity. LY2606368 Chemical Structure
  3. GC16822 LY2835219 LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively. LY2835219 Chemical Structure
  4. GC11823 LY2835219 free base A dual inhibitor of Cdk4 and Cdk6 LY2835219 free base Chemical Structure
  5. GC11971 LY2857785 CDK9 inhibitor LY2857785 Chemical Structure
  6. GC33057 LY3295668 (AK-01) LY3295668 (AK-01) (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668 (AK-01) Chemical Structure
  7. GC44100 LysoFP-NH2 LysoFP-NH2 is the fluorescent form of the lysosomal turn-on fluorescent probe for carbon monoxide (CO) lysoFP-NO2. LysoFP-NH2 Chemical Structure
  8. GC40021 LysoFP-NO2 LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome. LysoFP-NO2 Chemical Structure
  9. GC52358 Malachite Green (chloride) A triphenylmethane dye Malachite Green (chloride) Chemical Structure
  10. GC41186 Malformin C Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C Chemical Structure
  11. GC61400 MAP4343 MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 Chemical Structure
  12. GC62205 Maytansine Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. Maytansine Chemical Structure
  13. GC32895 Maytansinol (Ansamitocin P-0) Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and induces microtubule disassembly in vitro. Maytansinol (Ansamitocin P-0) Chemical Structure
  14. GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor MB 0223 Chemical Structure
  15. GC36560 Mc-MMAD Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. MMAD is a potent tubulin inhibitor. Mc-MMAD is a drug-linker conjugate for ADC. Mc-MMAD Chemical Structure
  16. GC36561 Mc-MMAE Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE Chemical Structure
  17. GC18363 Mca-DEVDAPK(Dnp)-OH Mca-DEVDAPK(Dnp)-OH is a fluorogenic substrate for caspase-3. Mca-DEVDAPK(Dnp)-OH Chemical Structure
  18. GC44132 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 Chemical Structure
  19. GC34068 McMMAF (Maleimidocaproyl monomethylauristatin F) McMMAF (Maleimidocaproyl monomethylauristatin F) is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor. McMMAF (Maleimidocaproyl monomethylauristatin F) Chemical Structure
  20. GC10200 Mdivi 1

    A mitochondrial division inhibitor

     Mdivi 1 Chemical Structure
  21. GC17649 Mebendazole broad-spectrum anthelmintic that inhibits intestinal microtubule synthesis Mebendazole Chemical Structure
  22. GC49486 Meglutol-d3 An internal standard for the quantification of meglutol Meglutol-d3 Chemical Structure
  23. GC47619 Menaquinone 4-d7 An internal standard for the quantification of menaquinone 4 Menaquinone 4-d7 Chemical Structure
  24. GC19244 Mertansine Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine Chemical Structure
  25. GC16607 Mesalamine 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Mesalamine Chemical Structure
  26. GC61043 Mesalamine impurity P Mesalamine impurity P is an impurity of Mesalamine. Mesalamine impurity P Chemical Structure
  27. GC49065 Metacetamol A derivative of acetaminophen Metacetamol Chemical Structure
  28. GC47645 Methidathion An organophosphate insecticide Methidathion Chemical Structure
  29. GC47646 Methiocarb A carbamate pesticide Methiocarb Chemical Structure
  30. GC47660 Methyl Parathion An organophosphate insecticide Methyl Parathion Chemical Structure
  31. GC40036 MHAPC-Chol MHAPC-Chol is a cationic cholesterol. MHAPC-Chol Chemical Structure
  32. GC36608 Microtubule inhibitor 1 Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC50 value of 9-16 nM in cancer cells. Microtubule inhibitor 1 Chemical Structure
  33. GC13491 Mirin Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Mirin Chemical Structure
  34. GC44200 Mitomycin A Mitomycin A is a bacterial metabolite originally isolated from S. Mitomycin A Chemical Structure
  35. GC16030 MK-1775 MK-1775 (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM. MK-1775 Chemical Structure
  36. GC61072 MK-28 MK-28 is a potent and selective PERK activator. MK-28 Chemical Structure
  37. GC10442 MK-8745 Aurora A inhibitor,potent and selective MK-8745 Chemical Structure
  38. GC16374 MK-8776(SCH-900776) MK-8776(SCH-900776) (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. MK-8776(SCH-900776) shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively. MK-8776(SCH-900776) Chemical Structure
  39. GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1 Chemical Structure
  40. GC14800 ML 141 Cdc42 GTPase inhibitor ML 141 Chemical Structure
  41. GC14162 ML167 Clk4 inhibitor,highly selective ML167 Chemical Structure
  42. GC32785 ML327 ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT). ML327 Chemical Structure
  43. GC10163 MLN0905 Potent PLK1 inhibitor MLN0905 Chemical Structure
  44. GC13096 MLS-573151 Cdc42 inhibitor MLS-573151 Chemical Structure
  45. GC64591 MM41 MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM. MM41 Chemical Structure
  46. GC15798 MMAD MMAD Chemical Structure
  47. GC63461 MMAE-d8

    MMAE-d8 (Monomethyl auristatin E-d8) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.

     MMAE-d8 Chemical Structure
  48. GC10034 MMAF Anti-mitotic/anti-tubulin/antineoplastic agent MMAF Chemical Structure
  49. GC36633 MMAF Hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride Chemical Structure
  50. GC38397 MMAF sodium MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium Chemical Structure
  51. GC63774 MMAF-d8 hydrochloride D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent. MMAF-d8 hydrochloride Chemical Structure
  52. GC44235 MMP Inhibitor I (trifluoroacetate salt) MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). MMP Inhibitor I (trifluoroacetate salt) Chemical Structure
  53. GC18218 MMP-3 Inhibitor

    MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.

     MMP-3 Inhibitor Chemical Structure
  54. GC40624 MMP-3 Inhibitor VIII Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 Inhibitor VIII Chemical Structure
  55. GC18616 MMP-8 Inhibitor I MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. MMP-8 Inhibitor I Chemical Structure
  56. GC14929 Monastrol

    Eg5 inhibitor

     Monastrol Chemical Structure
  57. GC15592 Moniliformin (sodium salt) induces mitotic arrest at the metaphase stage Moniliformin (sodium salt) Chemical Structure
  58. GC17276 Monomethyl auristatin E

    A potent antimitotic compound

     Monomethyl auristatin E Chemical Structure
  59. GC45744 monoMICAAc A solvatochromic fluorescent pH probe monoMICAAc Chemical Structure
  60. GC15285 MPC 6827 hydrochloride MPC 6827 hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. MPC 6827 hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. MPC 6827 hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types. MPC 6827 hydrochloride Chemical Structure
  61. GC10083 MPI-0479605 Mps1 inhibitor,selective and ATP competitive MPI-0479605 Chemical Structure
  62. GC11292 Mps1-IN-1

    Mps1 kinase inhibitor

     Mps1-IN-1 Chemical Structure
  63. GC50110 Mps1-IN-1 dihydrochloride Selective Mps1 kinase inhibitor Mps1-IN-1 dihydrochloride Chemical Structure
  64. GC15745 Mps1-IN-2 Mps1 kinase inhibitor Mps1-IN-2 Chemical Structure
  65. GC36651 Mps1-IN-3 Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3 Chemical Structure
  66. GC65339 Mps1-IN-3 hydrochloride Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model. Mps1-IN-3 hydrochloride Chemical Structure
  67. GC40048 MPS1/TTK Inhibitor MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. MPS1/TTK Inhibitor Chemical Structure
  68. GC41564 MPT0B014 An inhibitor of tubulin polymerization MPT0B014 Chemical Structure
  69. GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. MPT0B392 Chemical Structure
  70. GC62657 MRIA9 MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively. MRIA9 Chemical Structure
  71. GC45515 MX1013   MX1013 Chemical Structure
  72. GC66457 MY-875 MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity. MY-875 Chemical Structure
  73. GC69516 MY-943

    MY-943 is an effective tubulin polymerization and LSD1 inhibitor with anti-cancer activity. MY-943 induces G2/M phase arrest and cell apoptosis, and inhibits cell migration, making it suitable for gastric cancer research.

     MY-943 Chemical Structure
  74. GC38589 MYCi361 MYCi361 (NUCC-0196361) is a MYC inhibitor with the Kd of 3.2 μM for binding to MYC. MYCi361 (NUCC-0196361) suppresses tumor growth and enhances anti-PD1 immunotherapy. MYCi361 Chemical Structure
  75. GC38588 MYCi975 MYCi975 Chemical Structure
  76. GC60259 MYCMI-6 MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6?μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5?μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis. MYCMI-6 Chemical Structure
  77. GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc. Mycro 3 could be used for the research of pancreatic cancer. Mycro 3 Chemical Structure
  78. GC15773 Myoseverin microtubule-binding molecule Myoseverin Chemical Structure
  79. GC44260 Myristoyl Coenzyme A (hydrate)

    Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid.

     Myristoyl Coenzyme A (hydrate) Chemical Structure
  80. GC45958 Myrothecine A A trichothecene mycotoxin Myrothecine A Chemical Structure
  81. GC49491 N′-Nitrosonornicotine-d4 An internal standard for the quantification of N’-nitrosonornicotine N′-Nitrosonornicotine-d4 Chemical Structure
  82. GC49163 N’-Nitrosonornicotine An N-nitrosamine and a carcinogen N’-Nitrosonornicotine Chemical Structure
  83. GC45667 N-(p-Tosyl)-GPR-pNA (acetate) A colorimetric thrombin substrate N-(p-Tosyl)-GPR-pNA (acetate) Chemical Structure
  84. GC18445 N-Deacetylcolchicine An inhibitor of microtubule polymerization N-Deacetylcolchicine Chemical Structure
  85. GC44343 n-Decyl-β-D-maltoside n-Decyl-β-D-maltoside is a nonionic surfactant that is commonly used to solubilize and stabilize membrane proteins. n-Decyl-β-D-maltoside Chemical Structure
  86. GC52007 N-hydroxylamine Dapsone An active metabolite of dapsone N-hydroxylamine Dapsone Chemical Structure
  87. GC49351 N-Nitroso Atenolol A genotoxic derivative of (±)-atenolol N-Nitroso Atenolol Chemical Structure
  88. GC49394 N-Nitroso Fluoxetine A derivative of fluoxetine N-Nitroso Fluoxetine Chemical Structure
  89. GC49353 N-Nitroso Metoprolol A genotoxic derivative of metoprolol N-Nitroso Metoprolol Chemical Structure
  90. GC44430 n-Nonyl-β-D-glucopyranoside n-Nonyl-β-D-glucopyranoside is an anionic alkylglucoside chiral surfactant that is commonly used for the solubilization and crystallization of biological membrane proteins. n-Nonyl-β-D-glucopyranoside Chemical Structure
  91. GC45833 N-Oleoyl-L-phenylalanine An N-acyl amide N-Oleoyl-L-phenylalanine Chemical Structure
  92. GC47806 N-p-Tosyl-Gly-Pro-Lys-pNA (acetate) A colorimetric plasmin substrate N-p-Tosyl-Gly-Pro-Lys-pNA (acetate) Chemical Structure
  93. GC44313 Naphthofluorescein Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein Chemical Structure
  94. GC12491 Narciclasine A plant growth regulator with anticancer activity Narciclasine Chemical Structure
  95. GC49204 Nefazodone-d6 (hydrochloride) An internal standard for the quantification of nefazodone Nefazodone-d6 (hydrochloride) Chemical Structure
  96. GC45523 Nemorosone   Nemorosone Chemical Structure
  97. GC10716 Netarsudil (AR-13324) ROCK inhibitor Netarsudil (AR-13324) Chemical Structure
  98. GC12515 NMS-1286937 NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM. NMS-1286937 Chemical Structure
  99. GC36752 NMS-P715 An Mps1/TTK inhibitor NMS-P715 Chemical Structure
  100. GC14075 Nocodazole A tubulin production inhibitor,anti-neoplastic agent Nocodazole Chemical Structure
  101. GC47803 Noscapine-13C-d3 An internal standard for the quantification of noscapine Noscapine-13C-d3 Chemical Structure

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