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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Targets for  Cell Cycle/Checkpoint

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC44730 proTAME

    proTAME is a cell-permeable prodrug form of N-4-tosyl-L-arginine methyl ester, an inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that is converted to TAME by intracellular esterases.

     proTAME Chemical Structure
  3. GC44732 Protopine (hydrochloride) Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities. Protopine (hydrochloride) Chemical Structure
  4. GC49914 Pt(II)-NHC Complex 2C An inducer of immunogenic cancer cell death Pt(II)-NHC Complex 2C Chemical Structure
  5. GC69776 PT-262

    PT-262 is an effective ROCK inhibitor with an IC50 value of approximately 5 μM. PT-262 induces loss of mitochondrial membrane potential and increases activation of caspase-3 and cell apoptosis. PT-262 inhibits phosphorylation of ERK and CDC2 through a p53-independent pathway. PT-262 blocks cellular cytoskeleton function and cell migration. PT-262 has anti-cancer activity.

     PT-262 Chemical Structure
  6. GC44740 PtdIns-(1,2-dioctanoyl) (sodium salt) The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. PtdIns-(1,2-dioctanoyl) (sodium salt) Chemical Structure
  7. GC44743 PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) Chemical Structure
  8. GC44748 PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) Chemical Structure
  9. GC44750 PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) Chemical Structure
  10. GC44753 PtdIns-(3,4,5)-P3-biotin (sodium salt) The PtdIn phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(3,4,5)-P3-biotin (sodium salt) Chemical Structure
  11. GC44759 PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) Chemical Structure
  12. GC52484 Purified Ganglioside Mixture (bovine) (ammonium salt) A mixture of purified bovine gangliosides Purified Ganglioside Mixture (bovine) (ammonium salt) Chemical Structure
  13. GC14707 Purvalanol A potent, and cell-permeable CDK inhibitor Purvalanol A Chemical Structure
  14. GC16268 Purvalanol B CDK1/CDK2/CDK4 inhibitor Purvalanol B Chemical Structure
  15. GC45552 Pyrenophorol   Pyrenophorol Chemical Structure
  16. GC15162 Pyridostatin

    Pyridostatin is a highly selective G-quadruplex-binding small molecule that was designed to target polymorphic G-quadruplex structures regardless of sequence variability.

     Pyridostatin Chemical Structure
  17. GC48016 Pyridostatin (trifluoroacetate salt) Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin (trifluoroacetate salt) promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin (trifluoroacetate salt) targets the proto-oncogene Src. Pyridostatin (trifluoroacetate salt) reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells. Pyridostatin (trifluoroacetate salt) Chemical Structure
  18. GC37043 Pyridostatin hydrochloride Pyridostatin (RR82) hydrochloride is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin hydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin hydrochloride targets the proto-oncogene Src. Pyridostatin hydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells. Pyridostatin hydrochloride Chemical Structure
  19. GC17801 PYZD-4409 E1 enzyme inhibitor PYZD-4409 Chemical Structure
  20. GC52057 QN523 An anticancer agent QN523 Chemical Structure
  21. GC45903 Quazinone A PDE3 inhibitor Quazinone Chemical Structure
  22. GC48019 Quercetin (hydrate) A flavonoid with diverse biological activities Quercetin (hydrate) Chemical Structure
  23. GC46210 Quinacrine mustard (hydrochloride) Quinacrine mustard (hydrochloride) is a fluorochrome. Quinacrine mustard (hydrochloride) Chemical Structure
  24. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist Quininib Chemical Structure
  25. GC17400 R547 CDK1/2/4 inhibitor,ATP-competitive R547 Chemical Structure
  26. GC49771 rac-Hesperetin-d3 An internal standard for the quantification of hesperetin rac-Hesperetin-d3 Chemical Structure
  27. GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril Racecadotril-d5 Chemical Structure
  28. GC19306 RAD51 Inhibitor B02 RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 uM. RAD51 Inhibitor B02 Chemical Structure
  29. GC63165 RAD51-IN-1 RAD51-IN-1, a derivative of ?B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research. RAD51-IN-1 Chemical Structure
  30. GC65383 RAD51-IN-2 RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1. RAD51-IN-2 Chemical Structure
  31. GC68416 RAD51-IN-3 RAD51-IN-3 Chemical Structure
  32. GC67888 RAD51-IN-5 RAD51-IN-5 Chemical Structure
  33. GC52054 Ranitidine S-oxide Ranitidine S-oxide is the metabolite of Ranitidine. Ranitidine S-oxide Chemical Structure
  34. GC52196 RGD Peptide RGD Peptide acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. RGD Peptide Chemical Structure
  35. GC45798 Rhein-13C4

    An internal standard for the quantification of rhein

     Rhein-13C4 Chemical Structure
  36. GC33310 Rho-Kinase-IN-1 Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. Rho-Kinase-IN-1 Chemical Structure
  37. GC66050 Rho-Kinase-IN-2 Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). Rho-Kinase-IN-2 can be used in Huntington's research. Rho-Kinase-IN-2 Chemical Structure
  38. GC44829 Rhod-5N (potassium salt) Rhod-5N is a low affinity fluorescent calcium probe (Kd = 320 μM). Rhod-5N (potassium salt) Chemical Structure
  39. GC18140 RI-1 A RAD51 inhibitor RI-1 Chemical Structure
  40. GC12752 RI-2 Optimized reversible RAD51 inhibitor RI-2 Chemical Structure
  41. GC12415 Rigosertib

    PI3K/PLK1 inhibitor

     Rigosertib Chemical Structure
  42. GC14358 Rigosertib (ON-01910,Estybon) Plk1 inhibitor Rigosertib (ON-01910,Estybon) Chemical Structure
  43. GC13580 Rigosertib sodium

    Non-ATP-competitive inhibitor of PLK1

     Rigosertib sodium Chemical Structure
  44. GC37534 Ripasudil free base Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. Ripasudil free base Chemical Structure
  45. GC48401 Risuteganib (trifluoroacetate salt) An anti-integrin peptide Risuteganib (trifluoroacetate salt) Chemical Structure
  46. GC44846 RK-682 (calcium salt) Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. RK-682 (calcium salt) Chemical Structure
  47. GC50092 RKI 1447 dihydrochloride Potent and selective ROCK inhibitor; antitumor RKI 1447 dihydrochloride Chemical Structure
  48. GC44847 RKI-1313 A ROCK1 and ROCK2 inhibitor RKI-1313 Chemical Structure
  49. GC15437 RKI-1447 A ROCK1 and ROCK2 inhibitor RKI-1447 Chemical Structure
  50. GC12348 Ro 3306 An ATP-competitive, potent CDK1 inhibitor Ro 3306 Chemical Structure
  51. GC13903 Ro3280 PLK1 inhibitor,potent and highly selective Ro3280 Chemical Structure
  52. GC37551 ROCK inhibitor-2 ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. ROCK inhibitor-2 Chemical Structure
  53. GC31952 ROCK-IN-1 ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2. ROCK-IN-1 Chemical Structure
  54. GC66338 ROCK1-IN-1 ROCK1-IN-1 is a ROCK1 inhibitor with a Ki value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction. ROCK1-IN-1 Chemical Structure
  55. GC31883 ROCK2-IN-2 ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. ROCK2-IN-2 Chemical Structure
  56. GC33169 Rosabulin (STA 5312) Rosabulin (STA 5312) (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin (STA 5312) has broad-spectrum anti-tumor activity. Rosabulin (STA 5312) Chemical Structure
  57. GC11401 Roscovitine (Seliciclib,CYC202) Roscovitine (Seliciclib,CYC202) (Roscovitine) is an orally bioavailable and selective CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively. Roscovitine (Seliciclib,CYC202) Chemical Structure
  58. GC64278 RP-3500 RP-3500 (ATR inhibitor 4) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. RP-3500 shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. RP-3500 has potent antitumor activity. RP-3500 Chemical Structure
  59. GC16265 RS-1 RAD51 activator RS-1 Chemical Structure
  60. GC18847 RSM-932A RSM-932A is a ChoKα inhibitor RSM-932A Chemical Structure
  61. GC17150 Ryuvidine SETD8 protein lysine methyltransferase (PKMT) inhibitor Ryuvidine Chemical Structure
  62. GC49532 S-(1,2-Dichlorovinyl)-Cysteine (hydrochloride) A nephrotoxin and metabolite of trichloroethylene S-(1,2-Dichlorovinyl)-Cysteine (hydrochloride) Chemical Structure
  63. GC46224 S-Phenylcysteine An adduct S-Phenylcysteine Chemical Structure
  64. GC18852 S14161 D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. S14161 Chemical Structure
  65. GC38945 S516 S516 (Compound 22) is an active metabolite of CKD-516 and a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. S516 has marked antitumor activity. S516 Chemical Structure
  66. GC49093 Safflower Red A red pigment with diverse biological activities Safflower Red Chemical Structure
  67. GC38845 sAJM589 sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM. sAJM589 Chemical Structure
  68. GC13759 SAR407899 ATP-competitive ROCK inhibitor SAR407899 Chemical Structure
  69. GC16289 SAR407899 hydrochloride ATP-competitive ROCK inhibitor SAR407899 hydrochloride Chemical Structure
  70. GC46218 Satratoxin G A macrocyclic trichothecene mycotoxin Satratoxin G Chemical Structure
  71. GC46219 Satratoxin H A trichothecene mycotoxin Satratoxin H Chemical Structure
  72. GC11022 SB 218078 checkpoint kinase 1 (Chk1) inhibitor SB 218078 Chemical Structure
  73. GC15170 SB 772077B dihydrochloride Rho-kinase (ROCK) inhibitor SB 772077B dihydrochloride Chemical Structure
  74. GC66437 SB-216 SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research. SB-216 Chemical Structure
  75. GC12064 SB1317 A multi-kinase inhibitor SB1317 Chemical Structure
  76. GC14600 SB743921 SB743921 is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB743921 Chemical Structure
  77. GC14644 SBE 13 HCl SBE 13 HCl is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE 13 HCl poorly inhibits Plk2 (IC50>66μM) or Plk3 (IC50=875nM). SBE 13 HCl Chemical Structure
  78. GC37601 SBE13 SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM). SBE13 Chemical Structure
  79. GC37606 SCH-1473759 hydrochloride SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively. SCH-1473759 hydrochloride Chemical Structure
  80. GC17792 SCH900776 S-isomer SCH900776 S-isomer Chemical Structure
  81. GN10091 Schaftoside Schaftoside Chemical Structure
  82. GC49674 Schizandrin Schizandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schizandrin Chemical Structure
  83. GC39798 Scoulerine Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (?-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. Scoulerine Chemical Structure
  84. GC49723 SenTraGor™ Cell Senescence Reagent A cellular senescence detection reagent SenTraGor™ Cell Senescence Reagent Chemical Structure
  85. GC48076 Sesquicillin A A fungal metabolite Sesquicillin A Chemical Structure
  86. GC10019 SF1670 PTEN inhibitor, potent and specific SF1670 Chemical Structure
  87. GC49713 SIKVAV (acetate) A laminin α1-derived peptide SIKVAV (acetate) Chemical Structure
  88. GC49002 Sinigrin (hydrate) A glucosinolate with diverse biological activities Sinigrin (hydrate) Chemical Structure
  89. GC64539 SKLB-197 SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. SKLB-197 Chemical Structure
  90. GC12827 SLx-2119 A ROCK2 inhibitor SLx-2119 Chemical Structure
  91. GC11396 SNS-032 (BMS-387032) SNS-032 (BMS-387032) (BMS-387032) is a potent and selective inhibitor ofCDK2, CDK7, and CDK9 withIC50sof 38 nM, 62 nM and 4 nM, respectively. SNS-032 (BMS-387032) has antitumor effect. SNS-032 (BMS-387032) Chemical Structure
  92. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. SNS-314 Chemical Structure
  93. GC32935 Soblidotin (Auristatin PE) Soblidotin (Auristatin PE) (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization. Soblidotin (Auristatin PE) Chemical Structure
  94. GC48084 Sodium 4-Phenylbutyrate-d11 Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Sodium 4-Phenylbutyrate-d11 Chemical Structure
  95. GC65887 SOP1812 SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer. SOP1812 Chemical Structure
  96. GC63351 Sovesudil Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil Chemical Structure
  97. GC63716 Sovesudil hydrochloride Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride Chemical Structure
  98. GC64019 Sovilnesib Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer. Sovilnesib Chemical Structure
  99. GC48092 Spinosad A naturally-occurring insecticide Spinosad Chemical Structure
  100. GC41258 Spiroxamine Spiroxamine is a tertiary amine fungicide and an inhibitor of δ14 reductase/δ8→δ7 isomerase. Spiroxamine Chemical Structure
  101. GC44946 Sporidesmolide III Sporidesmolide III is a cyclodepsipeptide originally isolated from P. Sporidesmolide III Chemical Structure

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