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Home >> Signaling Pathways >> Metabolism

Metabolism

Products for  Metabolism

  1. Cat.No. Product Name Information
  2. GC15995 BMS 687453 PPARα agonist BMS 687453 Chemical Structure
  3. GC50257 BMS 795311 Potent cholesteryl ester transfer protein (CETP) inhibitor BMS 795311 Chemical Structure
  4. GC68778 BMS-262084

    BMS-262084 is an effective, selective, and irreversible inhibitor of factor XIa with an IC50 value of 2.8 nM for human factor XIa. BMS-262084 also inhibits human pancreatic trypsin (IC50=5 nM). BMS-262084 has anti-thrombotic properties.

     BMS-262084 Chemical Structure
  5. GC32614 BMS-654457 BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively. BMS-654457 Chemical Structure
  6. GC31479 BMS-819881 BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 Chemical Structure
  7. GC35536 BMS-962212 BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 Chemical Structure
  8. GC19079 BMS-986205 BMS-986205 (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. BMS-986205 is well tolerated with potent pharmacodynamic activity in advanced cancers. BMS-986205 Chemical Structure
  9. GC62496 BMS-986242 BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer. BMS-986242 Chemical Structure
  10. GC33345 BN82002 BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 ?M, respectively. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase. BN82002 Chemical Structure
  11. GC64699 Bocidelpar Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta (PPAR-δ). Bocidelpar Chemical Structure
  12. GC42963 BODIPY-C12 Ceramide (d18:1/12:0) BODIPY-C12 Ceramide (B12Cer) is a fluorescently-tagged form of C12 ceramide that displays excitation/emission maxima of 505/540 nm, respectively. BODIPY-C12 Ceramide (d18:1/12:0) Chemical Structure
  13. GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. BOLD-100 Chemical Structure
  14. GC46943 Boscalid A broad-spectrum carboxamide fungicide Boscalid Chemical Structure
  15. GC46945 Bourgeonal An hOR17-4 agonist Bourgeonal Chemical Structure
  16. GC35543 BPN14770 BPN14770 (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. BPN14770 Chemical Structure
  17. GC18718 bpV(pic) (potassium hydrate) bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). bpV(pic) (potassium hydrate) Chemical Structure
  18. GC49885 BQ-3020 (trifluoroacetate salt) A peptide ETB receptor antagonist BQ-3020 (trifluoroacetate salt) Chemical Structure
  19. GC10737 Brinzolamide A potent carbonic anhydrase inhibitor Brinzolamide Chemical Structure
  20. GC46101 Brinzolamide-d5 An internal standard for the quantification of brinzolamide Brinzolamide-d5 Chemical Structure
  21. GC15472 BRL 50481 PDE7 inhibitor,potent and selective BRL 50481 Chemical Structure
  22. GC49085 Brombuterol (hydrochloride) A β2-AR agonist Brombuterol (hydrochloride) Chemical Structure
  23. GC11021 Bromoenol lactone Inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) Bromoenol lactone Chemical Structure
  24. GC34070 Brusatol (NSC 172924) Brusatol (NSC 172924) (NSC172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol (NSC 172924) enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol (NSC 172924) can be developed into an adjuvant chemotherapeutic agent. Brusatol (NSC 172924) increases cellular apoptosis. Brusatol (NSC 172924) Chemical Structure
  25. GC38467 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell. BTdCPU Chemical Structure
  26. GC35565 Bucladesine calcium salt Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt Chemical Structure
  27. GC42992 Butafosfan Butafosfan is an organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies. Butafosfan Chemical Structure
  28. GC42995 Butaprost (free acid) Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Butaprost (free acid) Chemical Structure
  29. GC10944 Butein Protein kinase inhibitor Butein Chemical Structure
  30. GC49136 Butenafine-13C-d3 (hydrochloride) An internal standard for the quantification of butenafine Butenafine-13C-d3 (hydrochloride) Chemical Structure
  31. GC30067 Butylhydroxyanisole (Butylated hydroxyanisole) Butylhydroxyanisole (Butylated hydroxyanisole) (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole (Butylated hydroxyanisole) Chemical Structure
  32. GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate Butyric Acid-d7 Chemical Structure
  33. GC46105 Butyrolactone II A fungal metabolite Butyrolactone II Chemical Structure
  34. GC43000 Butyryl-L-carnitine (chloride) Butyryl-L-carnitine is a butyrate ester of carnitine. Butyryl-L-carnitine (chloride) Chemical Structure
  35. GC46972 Butyryl-L-carnitine-d3 (chloride) An internal standard for the quantification of butyryl-L-carnitine Butyryl-L-carnitine-d3 (chloride) Chemical Structure
  36. GC15738 BVT 2733 BVT 2733 is a novel, small-molecule, nonsteroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 of 96 nM (mice). BVT 2733 Chemical Structure
  37. GC16256 BVT 948 An inhibitor of protein tyrosine phosphatases BVT 948 Chemical Structure
  38. GC14601 BW 755C dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways BW 755C Chemical Structure
  39. GC31915 BW-A 78U BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U Chemical Structure
  40. GC19432 BXL-628 BXL-628 (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. BXL-628 Chemical Structure
  41. GC43006 C12 Ceramide (d18:1/12:0) C12 Ceramide (d18:1/12:0) (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12 Ceramide (d18:1/12:0) Chemical Structure
  42. GC43022 C14 Ceramide (d18:1/14:0)

    C14 Ceramide is an endogenous ceramide generated by ceramide synthase 6.

     C14 Ceramide (d18:1/14:0) Chemical Structure
  43. GC43032 C16 Globotriaosylceramide (d18:1/16:0) C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide. C16 Globotriaosylceramide (d18:1/16:0) Chemical Structure
  44. GC43033 C16 Lactosylceramide (d18:1/16:0) C16 Lactosylceramide is an endogenous bioactive sphingolipid. C16 Lactosylceramide (d18:1/16:0) Chemical Structure
  45. GC43035 C16 Sphingomyelin (d18:1/16:0) Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. C16 Sphingomyelin (d18:1/16:0) Chemical Structure
  46. GC43038 C17 Ceramide (d18:1/17:0) C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. C17 Ceramide (d18:1/17:0) Chemical Structure
  47. GC43041 C17 Globotriaosylceramide (d18:1/17:0) C17 Globotriaosylceramide is a sphingolipid that has been used as an internal standard for the quantification of globotriaosylceramides in plasma and urine from patients with Fabry disease by GC-MS. C17 Globotriaosylceramide (d18:1/17:0) Chemical Structure
  48. GC43049 C18 Globotriaosylceramide (d18:1/18:0) C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide. C18 Globotriaosylceramide (d18:1/18:0) Chemical Structure
  49. GC43059 C2 Adamantanyl Galactosylceramide (d18:1/2:0)

    C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid.

     C2 Adamantanyl Galactosylceramide (d18:1/2:0) Chemical Structure
  50. GC43068 C20 Sphingomyelin (d18:1/20:0) C20 Sphingomyelin is a naturally occurring sphingolipid. C20 Sphingomyelin (d18:1/20:0) Chemical Structure
  51. GC43071 C22 Sphingomyelin (d18:1/22:0) C22 Sphingomyelin is a naturally occurring form of sphingomyelin. C22 Sphingomyelin (d18:1/22:0) Chemical Structure
  52. GC11979 C3bot (154-182) transferase-deficient neurotrophic fragment of clostridial C3 protein C3bot (154-182) Chemical Structure
  53. GC49079 C82 An Mtb CdnP inhibitor C82 Chemical Structure
  54. GC68003 Cadisegliatin Cadisegliatin Chemical Structure
  55. GC43127 Calcitonin (salmon) (trifluoroacetate salt) Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. Calcitonin (salmon) (trifluoroacetate salt) Chemical Structure
  56. GC47020 Calcium D-Glucarate (hydrate) The calcium salt form of D-glucaric acid Calcium D-Glucarate (hydrate) Chemical Structure
  57. GC48932 Callosobruchusic Acid An insect pheromone Callosobruchusic Acid Chemical Structure
  58. GC65081 CALP1 TFA CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 ?M) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA Chemical Structure
  59. GC61508 CALP2 TFA CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 ?M) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 TFA Chemical Structure
  60. GC18106 Calyculin A Potent inhibitor of PP1 and PP2A Calyculin A Chemical Structure
  61. GC43136 Campestanol

    Campestanol is a phytosterol found in vegetables, fruits, nuts, and seeds.

     Campestanol Chemical Structure
  62. GC13771 Canagliflozin SGLT2 inhibitor,potent and selective Canagliflozin Chemical Structure
  63. GC39178 Canagliflozin D4 Canagliflozin D4 is a deuterium labeled Canagliflozin. Canagliflozin D4 Chemical Structure
  64. GC35603 Canagliflozin hemihydrate Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively. Canagliflozin hemihydrate Chemical Structure
  65. GC43140 Captopril Disulfide Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril. Captopril Disulfide Chemical Structure
  66. GC49111 Carbamazepine 10,11-epoxide An active metabolite of carbamazepine Carbamazepine 10,11-epoxide Chemical Structure
  67. GC41449 Carbazeran Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. Carbazeran Chemical Structure
  68. GC48348 Carbetocin (acetate) A peptide oxytocin receptor agonist Carbetocin (acetate) Chemical Structure
  69. GC32257 Carbosulfan Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan Chemical Structure
  70. GC49147 Carboxyphosphamide An inactive metabolite of cyclophosphamide Carboxyphosphamide Chemical Structure
  71. GC47040 Carebastine-d5 An internal standard for the quantification of carebastine Carebastine-d5 Chemical Structure
  72. GC47044 Carotenoid Mixture A mixture of carotenoids Carotenoid Mixture Chemical Structure
  73. GC17341 Carprofen COX inhibitor Carprofen Chemical Structure
  74. GC18498 Cathepsin L Inhibitor Cathepsin L Inhibitor (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor. Cathepsin L Inhibitor Chemical Structure
  75. GC60675 Caulophyllogenin Caulophyllogenin is a triterpene saponin extracted from M. Caulophyllogenin Chemical Structure
  76. GC40384 CAY10410 CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. CAY10410 Chemical Structure
  77. GC41264 CAY10434 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10434 Chemical Structure
  78. GC43160 CAY10485 Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 Chemical Structure
  79. GC40869 CAY10486 Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 Chemical Structure
  80. GC43161 CAY10502 Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 Chemical Structure
  81. GC43162 CAY10506 Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 Chemical Structure
  82. GC40764 CAY10514 CAY10514 is an aromatic analog of 8(S)-HETE. CAY10514 Chemical Structure
  83. GC18558 CAY10566 Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. CAY10566 Chemical Structure
  84. GC43174 CAY10573 The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 Chemical Structure
  85. GC43179 CAY10590 Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. CAY10590 Chemical Structure
  86. GC43180 CAY10592 Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. CAY10592 Chemical Structure
  87. GC18691 CAY10594 CAY10594 is an effective inhibitor of phospholipase D2 (PLD2) (IC50 140 nm in vitro and 110 nm in cells). CAY10594 Chemical Structure
  88. GC18876 CAY10599 Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. CAY10599 Chemical Structure
  89. GC47049 CAY10641 An inactive alcohol derivative of a highly potent cPLA2 inhibitor CAY10641 Chemical Structure
  90. GC18305 CAY10650 Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 Chemical Structure
  91. GC43195 CAY10703 Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. CAY10703 Chemical Structure
  92. GC46114 CAY10761 An ENPP1 inhibitor CAY10761 Chemical Structure
  93. GC47063 CAY10767 A PPARα agonist CAY10767 Chemical Structure
  94. GC48426 CAY10771 A dual agonist of FXR and PPARδ CAY10771 Chemical Structure
  95. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  96. GC13336 CBR-5884 selective inhibitor of PHGDH CBR-5884 Chemical Structure
  97. GC14727 CCCP Carbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the rate of ATP synthesis. CCCP Chemical Structure
  98. GC10223 CCT018159 inhibitor of the ATPase activity of Hsp90 CCT018159 Chemical Structure
  99. GC64388 CCT129957 CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM. CCT129957 Chemical Structure
  100. GC19094 CCT251236 CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. CCT251236 Chemical Structure
  101. GC35627 CDC25B-IN-1 CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase. CDC25B-IN-1 Chemical Structure

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