Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Targets for Neuroscience
- 5-HT Receptor(549)
- AChR(62)
- AChE(114)
- Alzheimer(109)
- Amyloid β(157)
- BACE(5)
- CGRP (33)
- COX(306)
- DAPK(6)
- Dopamine Receptor(319)
- GABA Receptor(239)
- Gap Junction(23)
- GluR(121)
- Histamine(4)
- Histamine Receptor(241)
- mPEGS-1(5)
- Muscarinic Receptor(46)
- Neuroscience Peptides(94)
- Nicotinic Receptor(70)
- P2 Receptor(2)
- P2X7 receptor(5)
- SSRIs(8)
- Substance P/NK1 Receptor(22)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(139)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(60)
- iGluR(139)
- nAChR(66)
- Beta-secretase(26)
- CaMK(33)
- Dopamine Transporter(17)
- Monoamine Oxidase(84)
- Serotonin Transporter(57)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Products for Neuroscience
- Cat.No. Product Name Information
- GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.
- GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727.
- GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM.
- GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor.
- GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist.
- GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
- GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8.
- GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
- GC31144 5-HT7 agonist 1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders.
- GC49655 5-hydroxy Buspirone A metabolite of buspirone
- GC49119 5-hydroxy Flunixin A metabolite of flunixin
- GC52172 5-hydroxy Indole-3-acetic Acid-d6
- GC49315 5-hydroxy Indomethacin A metabolite of indomethacin
- GC52106 5-hydroxy Isatin An inhibitor of MAO-A
- GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.
-
GC42553
5-hydroxy-Nω-methyl Tryptamine (oxalate)
5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants.
- GC11626 5-Iodo-A-85380 dihydrochloride α4β2 and α6β2 nicotinic acetylcholine receptors agonist
- GC14225 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative Precursor to ligand for the α4β2 nicotinic receptor
- GC14940 5-Methoxytryptamine
- GC64182 5-Methoxytryptamine hydrochloride
- GC14604 5-Methylfurmethiodide muscarinic agonist
- GC46706 5-Methyltetrahydrofolic Acid (hydrate) A biologically active form of folic acid
- GC17477 5-Nonyloxytryptamine oxalate 5-HT1B agonist
- GC41156 5-Octyl D-glutamate 5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases.
- GC41094 5-trans Latanoprost Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.
- GC41228 5-trans Latanoprost (free acid) Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.
- GC49438 5-trans-17-phenyl trinor Prostaglandin F2α The 5-trans isomer of 17-phenyl trinor PGF2α
- GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM.
- GC18176 5α,6β-Dihydroxycholestanol 5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.
- GC30943 6,2'-Dihydroxyflavone 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
- GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors
- GC11284 6-(4-Methoxyphenyl)-3-pyridazinamine GABAA receptor antagonist
- GC42572 6-Amino-8-trifluoromethylphenanthridine 6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine.
- GC40479 6-Aminophenanthridine 6-Aminophenanthridine is an antiprion agent.
- GC14000 6-fluoro-DL-Tryptophan 6-fluoro-DL-Tryptophan is a potent, competitive inhibitor of tryptophan hydroxylase.
-
GC42580
6-hydroxy Chlorzoxazone
6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone.
- GC49183 6-hydroxy Etodolac A metabolite of etodolac
- GC16267 6-Hydroxydopamine hydrobromide Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine.
- GC16153 6-methoxy Naphthalene Acetic Acid competitive, non-selective COX inhibitor
- GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2.
- GC30898 6-Methylflavone 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
- GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.
- GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist
- GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site
-
GC46242
7-dehydro Cholesterol-d7
7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol
- GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine
- GC35192 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B.
- GC16574 7-Hydroxy-DPAT hydrobromide D3 dopamine receptor agonist
- GC40572 7-keto Cholesterol A bioactive sterol and a major oxysterol component of oxidized LDL
-
GC46241
7-keto Cholesterol-d7
7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL
- GC48880 7-Methoxyflavone A flavone with diverse biological activities
- GC15338 8,11,14-Eicosatriynoic Acid A Cox, 12-LO, and 5-LO inhibitor
- GC40587 8,12-iso-iPF2α-VI 8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids.
- GC49017 8-hydroxy Amoxapine A metabolite of amoxapine
- GC42626 8-hydroxy Efavirenz 8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz.
- GC18654 8-hydroxy Loxapine 8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2.
- GC49544 8-hydroxy Mirtazapine A metabolite of mirtazapine
- GC14966 8-Hydroxy-DPAT hydrobromide 5-HT1A agonist
- GC12427 8-Hydroxy-PIPAT oxalate 5-HT1A receptor agonist
-
GC40759
8-methyl Nonanoic Acid
Capsaicin, the chemical that imparts the spicy-hot quality of chili peppers, is produced by the fruits of plants belonging to the Capsicum family.
- GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
- GC46753 9(S),12(S),13(S)-TriHOME An oxylipin
- GC42640 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid.
- GC14302 9,12-Octadecadiynoic Acid 9,12-Octadecadiynoic Acid (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor.
- GC13537 A 331440 dihydrochloride H3 receptor antagonist,non-imidazole,high affinity
- GC14610 A 412997 dihydrochloride Selective D4 agonist
- GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor
- GC17805 A 582941 A 582941 is a potent, selective and brain-penetrant partial agonist of α7 nAChR, with Kis of 10.8 and 16.7 nM in rat brain membranes and human frontal cortex, respectively.
- GC15498 A 68930 hydrochloride Agonist of D1-like dopamine receptor,potent and selective
- GC11183 A 77636 hydrochloride Agonist of D1-like dopamine receptor,potent and selective
- GC15434 A 839977 P2X7 antagonist,potent and selective
- GC16068 A 841720 mGluR1 antagonist, non-competitive
- GC15333 A 844606 α7 nAChR partial agonist
- GC11121 A 943931 dihydrochloride Antagonist of histamine H4 receptor,potent and selective
- GC17743 A 987306 H4 receptor antagonist,potent and selective
- GC63502 Aβ/tau aggregation-IN-1 Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor.
- GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.
-
GC19499
A-381393
A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist
- GC31214 A-437203 (Lu201640) A-437203 (Lu201640) is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively.
- GC11842 A-740003 A selective P2X7 antagonist
- GC15014 A-867744 A positive allosteric modulator of α7 nAChRs
- GC10641 AA 29504 GABAA receptor modulator
- GC31055 Abaperidone Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.
- GC42674 ABD459 ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM).
- GC11795 ABT 724 trihydrochloride Dopamine D4 receptor agonist,potent and selective
- GC35222 ABT-239 ABT-239 is a novel, highly efficacious, non-imidazole?class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.
- GC33552 ABT-670 ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human?D4, ferret?D4, and rat?D4, respectively.
- GP10121 Ac-Endothelin-1 (16-21), human
- GC42721 Ac-YVAD-CMK Ac-YVAD-CMK is a selective irreversible inhibitor of caspase-1 (Ki=0.8nM), which can prevent the proinflammatory cytokine IL-1β activation. Ac-YVAD-CMK can reduce the inflammatory response and induce a long-lasting neuroprotective effect.
- GC49263 Ac2-26 (human) (ammonium salt) An annexin A1-mimetic peptide
- GC30859 AC260584 AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6.
- GC14916 Acamprosate calcium An NMDA modulator
- GC46778 Acamprosate-d3 (calcium salt) An internal standard for the quantification of acamprosate
- GC17079 ACDPP hydrochloride mGlu5 receptor antagonist
- GC64332 Aceclidine Aceclidine is a modulator of M3 muscarinic acetylcholine receptor.
- GC12787 Aceclidine (hydrochloride) agonist of muscarinic receptors
- GC15902 Aceclofenac non-steroidal anti-inflammatory drug
- GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac
- GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac
- GC10454 Acemetacin COX inhibitor