Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(26)
- Aurora Kinase(47)
- Cdc42(4)
- Cdc7(4)
- Chk(16)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(91)
- E1 enzyme(1)
- G-quadruplex(14)
- Haspin(7)
- HMTase(1)
- Kinesin(26)
- Ksp(6)
- Microtubule/Tubulin(243)
- Mps1(15)
- Mitotic(11)
- RAD51(18)
- ROCK(71)
- Rho(13)
- PERK(11)
- PLK(37)
- PTEN(8)
- Wee1(7)
- PAK(21)
- Arp2/3 Complex(8)
- Dynamin(12)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(26)
- G2/S(10)
- Genotoxic Stress(18)
- Inositol Phosphates(18)
- Proteolysis(99)
- Cytoskeleton & Motor Proteins(53)
- Cellular Chaperones(8)
Products for Cell Cycle/Checkpoint
- Cat.No. Product Name Information
- GC11905 Cevipabulin Anti-microtubule agent
- GC35659 Cevipabulin fumarate Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.
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GC13606
CFI-400945
orally available, selective inhibitor of polo-like kinase 4 (PLK4)
- GC35660 CFI-400945 free base
- GC14526 CGK733 ATM/ATR inhibitor,potent and selective
- GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
- GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases
- GC14650 CGP60474 A CDK inhibitor
- GC15739 CHIR-124 Chk1 inhibitor,novel and potent
- GC43239 Chk2 Inhibitor Chk2 Inhibitor (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2 Inhibitor can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect.
- GC47079 Chloramine-T (hydrate) A common reagent
- GC43250 Cho-Arg (trifluoroacetate salt) Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group.
- GC50145 CHR 6494 trifluoroacetate CHR 6494 trifluoroacetate is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR 6494 trifluoroacetate inhibits histone H3T3 phosphorylation. CHR 6494 trifluoroacetate induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR 6494 trifluoroacetate can be used in the research of cancer.
- GC17254 CHR-6494 A selective Haspin protein kinase inhibitor
- GC16097 Chroman 1 A ROCK2 inhibitor
- GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor
- GC43265 Chromomycin A2 Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities.
- GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) A colorimetric chymotrypsin substrate
- GC12352 cis-trismethoxy Resveratrol Cis-trismethoxy resveratrol is a potent anti-mitotic reagent.Cis-trismethoxy resveratrol inhibits tubulin polymerization with an IC50 value of 4 μM.
- GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide A biotinylated and citrullinated mutant vimentin peptide
- GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide A biotinylated and citrullinated vimentin peptide
- GC14060 CK 666 Arp2/3 complex inhibitor that inhibits actin polymerization
- GC15076 CK 869 actin-related protein 2/3 (Arp2/3) complex inhibitor
- GC15894 CK-636 Arp2/3 complex inhibitor
- GC43286 CMPD101 A GRK2 and GRK3 inhibitor
- GC49345 Coelenterazine hcp A synthetic bioluminescent luciferin
- GC40664 Colcemid Colcemid is a cytoskeletal inhibitor that induces mitotic arrest in the G2/M phase or meiotic arrest in the vesicle rupture (GVBD) phase in mammalian cells or oocytes, respectively.
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GC13261
Colchicine
An inhibitor of microtubule polymerization
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GC47117
Colchicine-d6
An internal standard for the quantification of colchicine
- GC43300 Combretastatin A1 Combretastatin A1 is a cis-stilbene originally isolated from C.
- GC17631 Combretastatin A4 tubulin polymerization inhibitor
- GC43307 Concanamycin B Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM).
- GC43315 Corynecin IV Corynecin IV is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium.
- GC40663 Corynecin V Corynecin V is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium.
- GC63333 Cotosudil
- GC16489 CP-466722 ATM inhibitor,potent and reversible
- GC19112 Crolibulin Crolibulin is a small molecule tubulin polymerization inhibitor.
- GC45414 CRT0066854
- GC40482 Curvulin Curvulin is a phytotoxin first isolated from several species of the mold Curvularia.
- GC18028 CVT-313 A Cdk2 inhibitor
- GC11252 CW069 allosteric inhibitor of HSET, selective
- GC13268 Cyclapolin 9 PLK1 inhibitor
- GC49709 cyclo(RGDyC) (trifluoroacetate salt) A cyclic pentapeptide
- GC49716 Cyclo(RGDyK) (trifluoroacetate salt) A cyclic peptide ligand of αVβ3 integrin
- GC43346 Cyclopamine-KAAD Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist.
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GC43351
Cylindrospermopsin
Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease.
- GC45877 CYM 5478 An S1P2 agonist
- GC35789 Cys-mcMMAD Cys-mcMMAD is a drug-linker conjugate for ADC. MMAD is a potent tubulin inhibitor.
- GC43354 Cysmethynil Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis.
- GC11383 CYT997 (Lexibulin) CYT997 (Lexibulin) (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. CYT997 (Lexibulin) induces cell apoptosis and induces mitochondrial ROS generation in GC cells.
- GC49863 Cytarabine 5′-monophosphate An active metabolite of cytarabine
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GC32890
Cytochalasin B (Phomin)
Cytochalasin B is a cyto-permeable mycotoxin, and it is isolated from an ascomycete fungus belonging to the Phoma genus[1-2].
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GC13440
Cytochalasin D
An inhibitor of actin polymerization, selective
- GC10870 Cytochalasin J alters mitotic spindle microtubule organization and kinetochore structure
- GC43360 Cytostatin Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice.
- GC43361 Cytostatin (sodium salt) Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice.
- GC12384 D-64131 An inhibitor of tubulin polymerization
- GC40296 D-erythro-MAPP D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM).
- GC43513 D-myo-Inositol-1,2-diphosphate (sodium salt) Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals.
- GC43516 D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase.
- GC43517 D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt) The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure.
- GC43520 D-myo-Inositol-1,3-diphosphate (sodium salt) D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.
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GC43521
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction.
- GC43522 D-myo-Inositol-1,4,5-triphosphate (potassium salt) D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate.
- GC43523 D-myo-Inositol-1,4,5-triphosphate (sodium salt) Primary intracellular IP3 receptor agonist
- GC43524 D-myo-Inositol-1,4,6-triphosphate (sodium salt) D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals.
- GC43526 D-myo-Inositol-1,5,6-triphosphate (sodium salt) The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility.
- GC43540 D-myo-Inositol-4-phosphate (ammonium salt) D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.
- GC35797 D8-MMAD
- GC35798 D8-MMAF D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride. MMAF Hydrochloride, a potent tubulin polymerization inhibitor, is used as a antitumor agent and a cytotoxic component of antibody-drug conjugates (ADCs).
- GC35799 D8-MMAF hydrochloride
- GC41305 DA-3003-2 Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers.
- GC18421 Dabcyl-YVADAPV-EDANS Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1.
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GC43371
Dabigatran Acyl-β-D-Glucuronide
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran.
- GC49684 Dabigatran-13C-d3 An internal standard for the quantification of dabigatran
- GC49682 Dabigatran-d3 An internal standard for the quantification of dabigatran
- GC43379 Darinaparsin A dimethylated arsenic linked to glutathione
- GC68147 dAURK-4 hydrochloride
- GC49913 Davunetide (acetate) A neuroprotective ADNP-derived peptide
- GC43385 DC-Chol (hydrochloride) DC-Chol(hydrochloric acid) can inhibit the formation of Aβ40 fibers,DC-Chol(hydrochloric acid) can inhibit the amyloid formation of oxidized hCT.
- GC39486 DCLK1-IN-1 DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1+ pancreatic ductal adenocarcinoma (PDAC).
- GN10426 Deacetyltaxol
- GC18666 Debromohymenialdisine Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2.
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GC11835
Deferasirox
Oral iron chelator
- GC41304 Deoxybrevianamide E Deoxybrevianamide E is an alkaloid fungal metabolite that has been found in Aspergillus.
- GC38564 Deoxypodophyllotoxin Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae).
- GC47211 Dichlorvos An organophosphate insecticide
- GC49293 Dichlorvos-d6 An internal standard for the quantification of dichlorvos
- GC43461 Dihydrocytochalasin B Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly.
- GC43467 Dimethyldioctadecylammonium (bromide) Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid.
- GC32969 Dimethylenastron An inhibitor of EG5
- GC43469 Diminutol Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis.
- GC17648 Dinaciclib(SCH727965) Dinaciclib(SCH727965) (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
- GC43472 Dios-Arg (trifluoroacetate salt) Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group.
- GC60143 DM3 DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs).
- GC38355 DM3-SMe DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM.
- GC32810 DM4 DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.
- GC38468 DM4-SMe DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM.
- GC38460 DM4-SPDP DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
- GC43545 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9.