GPCR/G protein
- Neuropeptide FF/AF Receptors(43)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(415)
- Acetylcholine(19)
- Adenosine Deaminase(12)
- Adenosine Receptor(133)
- Adenosine Kinase(5)
- Adiponectin Receptor(4)
- Adrenergic Receptor(404)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(110)
- Bombesin Receptors(22)
- Bradykinin Receptors(27)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(137)
- Calcimimetic Agent(3)
- CaSR(24)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(79)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(82)
- CysLT1 receptor(1)
- Endothelin Receptor(50)
- EP1 Receptor(3)
- EP4 Receptor(5)
- ERRγ(2)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(20)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(22)
- GIP Receptor(5)
- Glucagon Receptor(66)
- Glucocorticoid Receptor(87)
- GLUT1(2)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(13)
- GPR109A(4)
- GPR119(11)
- GPR120(12)
- GPR35(8)
- GPR44(1)
- GPR55(10)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(55)
- LPA Receptor(15)
- LPL Receptor(60)
- LTD4 Receptor(2)
- mGluR (115)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(49)
- Melatonin Receptors(23)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(21)
- NK2 Receptors(7)
- NK3 Receptor(8)
- NOP Receptor(22)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(42)
- Oxytocin Receptors(21)
- P2Y Receptor(55)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(15)
- PGD2 Receptor(2)
- Prostaglandin Receptor(168)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(4)
- S1P receptor(9)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(34)
- Sigma Receptor(54)
- Vasopressin Receptor(33)
- 17,20-lyase(7)
- Ras(118)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(5)
- TSH Receptor(10)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(22)
- GPR84(5)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(4)
- CRFR(21)
- RGS Protein(7)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(23)
- GPR139(3)
- mAChR(179)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(72)
- cGMP(18)
- GRK(1)
Products for GPCR/G protein
- Cat.No. Product Name Information
- GC66030 CB1 agonist 1 CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders.
- GC31306 CB1 antagonist 1 CB1 antagonist 1 is an antagonist of CB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions.
- GC30935 CB1-IN-1 CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively.
- GC33756 CB2R-IN-1 CB2R-IN-1 is a potent cannabinoid CB2 receptor inverse agonist with a Ki of 0.9 nM.
- GC30875 CCG 203769 CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM.
-
GC14266
CCG 203971
Antifibrotic agent
- GC16137 CCG 2046 CCG 2046 is a RGS4 inhibitor with an IC50 of 4.3 μM against RGS4-Gαo interaction signal.
- GC16846 CCG 50014 RGS4 Inhibitor,potent and selective
- GC12795 CCG-1423 RhoA inhibitor
- GC38898 CCG-222740 CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.
- GC10658 CCG-63802
- GC14412 CCG-63808
- GC13327 CCK Octapeptide, non-sulfated CCK Octapeptide, non-sulfated is a synthetic desulfated octapeptides of cholecystokinin (CCK).
-
GC31558
CCK-A receptor inhibitor 1
CCK-A receptor inhibitor 1 is a cholecystokinin A (CCK-A) receptor inhibitor with a binging IC50 of 340 nM.
- GC30752 CCK-B Receptor Antagonist 1 CCK-B Receptor Antagonist 1 is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid.
- GC38746 CCK-B Receptor Antagonist 2 CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM.
- GC31996 CCR1 antagonist 1 CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity.
- GC31893 CCR1 antagonist 8 CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay.
-
GC30560
CCR2 antagonist 1
CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.
-
GC31911
CCR2 antagonist 3
CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist.
- GC60679 CCR2 antagonist 4 CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b.
- GC31714 CCR2-RA-[R] CCR2-RA -[R] can inhibit CCR2 in a non-competitive binding manner, mainly by blocking activation-related conformational changes and the formation of G-protein binding interfaces.
-
GC32017
CCR3 antagonist 1
CCR3 antagonist 1 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases.
- GC35626 CCR4 antagonist 2 CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.
- GC64441 CCR4 antagonist 3 CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.
- GC63857 CCR4 antagonist 3 hydrochloride CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist.
- GC32367 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2.
- GC67788 CCR6 antagonist 1
- GC34521 CCR6 inhibitor 1 CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM).
- GC65141 CCR8 antagonist 1 CCR8 antagonist 1 (compound 15) is a potente human CCR8 antagonist with a Ki of 1.6 nM.
- GC67897 CCR8 antagonist 2
- GC31330 CCX140
- GC31255 CDD0102 (CDD0102A) CDD0102 (CDD0102A) is a potent M1 Muscarinic receptor agonist.
- GC61805 Cefminox sodium Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity.
- GC12023 Celiprolol (hydrochloride) β1 adrenergic receptor antagonist and β2 adrenergic receptor partial agonist
- GC19100 Cenerimod Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.
-
GC19101
Cenicriviroc
Cenicriviroc (CVC) is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against both receptors.
- GC35650 Cenicriviroc Mesylate Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
- GC31283 Centanafadine (EB-1020) Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
- GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride)) Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
- GC18348 Ceralifimod Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively).
- GC63961 Cerlapirdine Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor.
- GC30008 Ceruletide (Caerulein) Ceruletide (Caerulein) is a decapeptide and a potent cholecystokinin receptor agonist.
- GC14215 Cevimeline A muscarinic receptor agonist
- GC43232 Cevimeline (hydrochloride) Cevimeline is a muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 μM for M2 and M4).
- GC17157 Cevimeline hydrochloride hemihydrate
- GC33146 CFMTI CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively.
- GC14674 CGH 2466 dihydrochloride adenosine receptor antagonist
- GC17717 CGP 12177 hydrochloride β1/β2-AR antagonist,β3 AR partial agonist
- GC38752 CGP 20712 A CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM.
- GC15354 CGP 20712 dihydrochloride β1 antagonist,highly potent and selective
- GC15406 CGP 42112 angiotensin AT2 receptor ligand
-
GC10167
CGP 71683 hydrochloride
NPY Y5 receptor antagonist
- GC32561 CGP48369 CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research.
- GC11928 CGRP (rat) CGRP (rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator.
- GC16147 CGRP 8-37 (human) CGRP 8-37 (human) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor.
- GC10927 CGRP 8-37 (rat) CGRP 8-37 (rat) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
- GC31981 CGS 15435 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
- GC10070 CGS 15943 adenosine receptor antagonist
- GC10172 CGS 21680 A selective agonist of the adenosine A2A receptor
- GC11978 CGS 21680 HCl CGS 21680 HCl is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
- GC13686 CH 275 Potent somatostatin receptor 1 (sst1) agonist
- GC30674 CHEMBL333994 (FK-480) CHEMBL333994 (FK-480) is a potent and orally effective Cholecystokinin A (CCK-A) antagonist, with an IC50 of 0.67 nM.
- GC35673 Chemerin-9 149-157 Chemerin-9 149-157 is a potent agonist of chemokine-like receptor 1 (CMKLR1) .
- GC50742 Chemerin-9, Mouse
- GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine
-
GC14216
Chlorpromazine HCl
dopamine receptor antagonist
- GC38693 Choline bitartrate Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders.
- GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist
- GC17963 CHPG Sodium salt mGlu5 agonist
- GC11797 CI 1020 endothelin-A receptor (ETA) antagonist
- GC13177 CI 988 CCK2 (CCK-B) receptor antagonist
- GC31994 CI-949 CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
- GC17571 Ciclesonide glucocorticoid
- GC32542 Cicloprolol hydrochloride Cicloprolol is a partial β 1-adrenoceptor agonist .
- GC35694 CID 16020046 CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC50 of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca2+ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function.
- GC10483 CID 2745687 GPR35 antagonist
-
GC12948
CID-1067700
competitive inhibitor of nucleotide binding by Ras-related GTPases
- GC68469 CID1231538
- GC47088 Cilostazol-d4 An internal standard for the quantification of cilostazol
- GC12626 Cimaterol β-Adrenergic agonist
- GC45826 Cimaterol-d7 An internal standard for the quantification of cimaterol
- GC62897 Cimbuterol-D9 Cimbuterol-D9 is the deuterium labeled Cimbuterol.
- GC30955 Cimetropium Bromide (DA-3177) Cimetropium Bromide (DA-3177) (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome.
- GC13518 Cinacalcet
- GC16708 Cinacalcet HCl Cinacalcet HCl (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
- GC63745 Cinacalcet-D3
- GC12230 Cinalukast CysLT1 (LTD4) leukotriene receptor antagonist
- GC16135 Cinanserin hydrochloride 5-HT2 antagonist
- GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors
- GC15218 Cirazoline hydrochloride α1 agonist
- GC38753 cis-Urocanic acid cis-Urocanic acid is a 5-HT2A receptor agonist.
- GC13533 Cisapride 5-HT4 receptor agonist
- GC25259 Cisapride hydrate Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
- GC12226 Cisatracurium Besylate Neuromuscular-blocking drug
- GC13583 CJ 033466 5-HT4 partial agonist
- GC10771 CJ-023423 CJ-023423 (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
- GC13284 CJ-42794 EP4 antagonist
-
GC43276
CL 316,243 (disodium salt)
A murine-selective β3 adrenoceptor agonist
- GC10509 Cladribine Apoptosis inducer in CLL cells