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Home >> Signaling Pathways >> GPCR/G protein

GPCR/G protein

Products for  GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC66030 CB1 agonist 1 CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders. CB1 agonist 1 Chemical Structure
  3. GC31306 CB1 antagonist 1 CB1 antagonist 1 is an antagonist of CB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions. CB1 antagonist 1 Chemical Structure
  4. GC30935 CB1-IN-1 CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively. CB1-IN-1 Chemical Structure
  5. GC33756 CB2R-IN-1 CB2R-IN-1 is a potent cannabinoid CB2 receptor inverse agonist with a Ki of 0.9 nM. CB2R-IN-1 Chemical Structure
  6. GC30875 CCG 203769 CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM. CCG 203769 Chemical Structure
  7. GC14266 CCG 203971

    Antifibrotic agent

     CCG 203971 Chemical Structure
  8. GC16137 CCG 2046 CCG 2046 is a RGS4 inhibitor with an IC50 of 4.3 μM against RGS4-Gαo interaction signal. CCG 2046 Chemical Structure
  9. GC16846 CCG 50014 RGS4 Inhibitor,potent and selective CCG 50014 Chemical Structure
  10. GC12795 CCG-1423 RhoA inhibitor CCG-1423 Chemical Structure
  11. GC38898 CCG-222740 CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis. CCG-222740 Chemical Structure
  12. GC10658 CCG-63802 CCG-63802 Chemical Structure
  13. GC14412 CCG-63808 CCG-63808 Chemical Structure
  14. GC13327 CCK Octapeptide, non-sulfated CCK Octapeptide, non-sulfated is a synthetic desulfated octapeptides of cholecystokinin (CCK). CCK Octapeptide, non-sulfated Chemical Structure
  15. GC31558 CCK-A receptor inhibitor 1

    CCK-A receptor inhibitor 1 is a cholecystokinin A (CCK-A) receptor inhibitor with a binging IC50 of 340 nM.

     CCK-A receptor inhibitor 1 Chemical Structure
  16. GC30752 CCK-B Receptor Antagonist 1 CCK-B Receptor Antagonist 1 is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid. CCK-B Receptor Antagonist 1 Chemical Structure
  17. GC38746 CCK-B Receptor Antagonist 2 CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 Chemical Structure
  18. GC31996 CCR1 antagonist 1 CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity. CCR1 antagonist 1 Chemical Structure
  19. GC31893 CCR1 antagonist 8 CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay. CCR1 antagonist 8 Chemical Structure
  20. GC30560 CCR2 antagonist 1

    CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

     CCR2 antagonist 1 Chemical Structure
  21. GC31911 CCR2 antagonist 3

    CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist.

     CCR2 antagonist 3 Chemical Structure
  22. GC60679 CCR2 antagonist 4 CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 Chemical Structure
  23. GC31714 CCR2-RA-[R] CCR2-RA -[R] can inhibit CCR2 in a non-competitive binding manner, mainly by blocking activation-related conformational changes and the formation of G-protein binding interfaces. CCR2-RA-[R] Chemical Structure
  24. GC32017 CCR3 antagonist 1

    CCR3 antagonist 1 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases.

     CCR3 antagonist 1 Chemical Structure
  25. GC35626 CCR4 antagonist 2 CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 Chemical Structure
  26. GC64441 CCR4 antagonist 3 CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity. CCR4 antagonist 3 Chemical Structure
  27. GC63857 CCR4 antagonist 3 hydrochloride CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3 hydrochloride Chemical Structure
  28. GC32367 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2. CCR5 antagonist 1 Chemical Structure
  29. GC67788 CCR6 antagonist 1 CCR6 antagonist 1 Chemical Structure
  30. GC34521 CCR6 inhibitor 1 CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 Chemical Structure
  31. GC65141 CCR8 antagonist 1 CCR8 antagonist 1 (compound 15) is a potente human CCR8 antagonist with a Ki of 1.6 nM. CCR8 antagonist 1 Chemical Structure
  32. GC67897 CCR8 antagonist 2 CCR8 antagonist 2 Chemical Structure
  33. GC31330 CCX140 CCX140 Chemical Structure
  34. GC31255 CDD0102 (CDD0102A) CDD0102 (CDD0102A) is a potent M1 Muscarinic receptor agonist. CDD0102 (CDD0102A) Chemical Structure
  35. GC61805 Cefminox sodium Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity. Cefminox sodium Chemical Structure
  36. GC12023 Celiprolol (hydrochloride) β1 adrenergic receptor antagonist and β2 adrenergic receptor partial agonist Celiprolol (hydrochloride) Chemical Structure
  37. GC19100 Cenerimod Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. Cenerimod Chemical Structure
  38. GC19101 Cenicriviroc

    Cenicriviroc (CVC) is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against both receptors.

     Cenicriviroc Chemical Structure
  39. GC35650 Cenicriviroc Mesylate Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity. Cenicriviroc Mesylate Chemical Structure
  40. GC31283 Centanafadine (EB-1020) Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Centanafadine (EB-1020) Chemical Structure
  41. GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride)) Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Centanafadine hydrochloride (EB-1020 (hydrochloride)) Chemical Structure
  42. GC18348 Ceralifimod Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). Ceralifimod Chemical Structure
  43. GC63961 Cerlapirdine Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine Chemical Structure
  44. GC30008 Ceruletide (Caerulein) Ceruletide (Caerulein) is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide (Caerulein) Chemical Structure
  45. GC14215 Cevimeline A muscarinic receptor agonist Cevimeline Chemical Structure
  46. GC43232 Cevimeline (hydrochloride) Cevimeline is a muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 μM for M2 and M4). Cevimeline (hydrochloride) Chemical Structure
  47. GC17157 Cevimeline hydrochloride hemihydrate Cevimeline hydrochloride hemihydrate Chemical Structure
  48. GC33146 CFMTI CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively. CFMTI Chemical Structure
  49. GC14674 CGH 2466 dihydrochloride adenosine receptor antagonist CGH 2466 dihydrochloride Chemical Structure
  50. GC17717 CGP 12177 hydrochloride β1/β2-AR antagonist,β3 AR partial agonist CGP 12177 hydrochloride Chemical Structure
  51. GC38752 CGP 20712 A CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A Chemical Structure
  52. GC15354 CGP 20712 dihydrochloride β1 antagonist,highly potent and selective CGP 20712 dihydrochloride Chemical Structure
  53. GC15406 CGP 42112 angiotensin AT2 receptor ligand CGP 42112 Chemical Structure
  54. GC10167 CGP 71683 hydrochloride

    NPY Y5 receptor antagonist

     CGP 71683 hydrochloride Chemical Structure
  55. GC32561 CGP48369 CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research. CGP48369 Chemical Structure
  56. GC11928 CGRP (rat) CGRP (rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. CGRP (rat) Chemical Structure
  57. GC16147 CGRP 8-37 (human) CGRP 8-37 (human) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. CGRP 8-37 (human) Chemical Structure
  58. GC10927 CGRP 8-37 (rat) CGRP 8-37 (rat) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. CGRP 8-37 (rat) Chemical Structure
  59. GC31981 CGS 15435 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. CGS 15435 Chemical Structure
  60. GC10070 CGS 15943 adenosine receptor antagonist CGS 15943 Chemical Structure
  61. GC10172 CGS 21680 A selective agonist of the adenosine A2A receptor CGS 21680 Chemical Structure
  62. GC11978 CGS 21680 HCl CGS 21680 HCl is a selective adenosine A2A receptor agonist with a Ki of 27 nM. CGS 21680 HCl Chemical Structure
  63. GC13686 CH 275 Potent somatostatin receptor 1 (sst1) agonist CH 275 Chemical Structure
  64. GC30674 CHEMBL333994 (FK-480) CHEMBL333994 (FK-480) is a potent and orally effective Cholecystokinin A (CCK-A) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 (FK-480) Chemical Structure
  65. GC35673 Chemerin-9 149-157 Chemerin-9 149-157 is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 149-157 Chemical Structure
  66. GC50742 Chemerin-9, Mouse Chemerin-9, Mouse Chemical Structure
  67. GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine Chlorpromazine D6 hydrochloride Chemical Structure
  68. GC14216 Chlorpromazine HCl

    dopamine receptor antagonist

     Chlorpromazine HCl Chemical Structure
  69. GC38693 Choline bitartrate Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders. Choline bitartrate Chemical Structure
  70. GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist CHPG Chemical Structure
  71. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt Chemical Structure
  72. GC11797 CI 1020 endothelin-A receptor (ETA) antagonist CI 1020 Chemical Structure
  73. GC13177 CI 988 CCK2 (CCK-B) receptor antagonist CI 988 Chemical Structure
  74. GC31994 CI-949 CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively. CI-949 Chemical Structure
  75. GC17571 Ciclesonide glucocorticoid Ciclesonide Chemical Structure
  76. GC32542 Cicloprolol hydrochloride Cicloprolol is a partial β 1-adrenoceptor agonist . Cicloprolol hydrochloride Chemical Structure
  77. GC35694 CID 16020046 CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC50 of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca2+ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function. CID 16020046 Chemical Structure
  78. GC10483 CID 2745687 GPR35 antagonist CID 2745687 Chemical Structure
  79. GC12948 CID-1067700

    competitive inhibitor of nucleotide binding by Ras-related GTPases

     CID-1067700 Chemical Structure
  80. GC68469 CID1231538 CID1231538 Chemical Structure
  81. GC47088 Cilostazol-d4 An internal standard for the quantification of cilostazol Cilostazol-d4 Chemical Structure
  82. GC12626 Cimaterol β-Adrenergic agonist Cimaterol Chemical Structure
  83. GC45826 Cimaterol-d7 An internal standard for the quantification of cimaterol Cimaterol-d7 Chemical Structure
  84. GC62897 Cimbuterol-D9 Cimbuterol-D9 is the deuterium labeled Cimbuterol. Cimbuterol-D9 Chemical Structure
  85. GC30955 Cimetropium Bromide (DA-3177) Cimetropium Bromide (DA-3177) (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. Cimetropium Bromide (DA-3177) Chemical Structure
  86. GC13518 Cinacalcet Cinacalcet Chemical Structure
  87. GC16708 Cinacalcet HCl Cinacalcet HCl (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment. Cinacalcet HCl Chemical Structure
  88. GC63745 Cinacalcet-D3 Cinacalcet-D3 Chemical Structure
  89. GC12230 Cinalukast CysLT1 (LTD4) leukotriene receptor antagonist Cinalukast Chemical Structure
  90. GC16135 Cinanserin hydrochloride 5-HT2 antagonist Cinanserin hydrochloride Chemical Structure
  91. GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors Cinitapride Hydrogen Tartrate Chemical Structure
  92. GC15218 Cirazoline hydrochloride α1 agonist Cirazoline hydrochloride Chemical Structure
  93. GC38753 cis-Urocanic acid cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid Chemical Structure
  94. GC13533 Cisapride 5-HT4 receptor agonist Cisapride Chemical Structure
  95. GC25259 Cisapride hydrate Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic. Cisapride hydrate Chemical Structure
  96. GC12226 Cisatracurium Besylate Neuromuscular-blocking drug Cisatracurium Besylate Chemical Structure
  97. GC13583 CJ 033466 5-HT4 partial agonist CJ 033466 Chemical Structure
  98. GC10771 CJ-023423 CJ-023423 (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). CJ-023423 Chemical Structure
  99. GC13284 CJ-42794 EP4 antagonist CJ-42794 Chemical Structure
  100. GC43276 CL 316,243 (disodium salt)

    A murine-selective β3 adrenoceptor agonist

     CL 316,243 (disodium salt) Chemical Structure
  101. GC10509 Cladribine Apoptosis inducer in CLL cells Cladribine Chemical Structure

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