GPCR/G protein
- Neuropeptide FF/AF Receptors(43)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(415)
- Acetylcholine(19)
- Adenosine Deaminase(12)
- Adenosine Receptor(133)
- Adenosine Kinase(5)
- Adiponectin Receptor(4)
- Adrenergic Receptor(404)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(110)
- Bombesin Receptors(22)
- Bradykinin Receptors(27)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(137)
- Calcimimetic Agent(3)
- CaSR(24)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(79)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(82)
- CysLT1 receptor(1)
- Endothelin Receptor(50)
- EP1 Receptor(3)
- EP4 Receptor(5)
- ERRγ(2)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(20)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(22)
- GIP Receptor(5)
- Glucagon Receptor(66)
- Glucocorticoid Receptor(87)
- GLUT1(2)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(13)
- GPR109A(4)
- GPR119(11)
- GPR120(12)
- GPR35(8)
- GPR44(1)
- GPR55(10)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(55)
- LPA Receptor(15)
- LPL Receptor(60)
- LTD4 Receptor(2)
- mGluR (115)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(49)
- Melatonin Receptors(23)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(21)
- NK2 Receptors(7)
- NK3 Receptor(8)
- NOP Receptor(22)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(42)
- Oxytocin Receptors(21)
- P2Y Receptor(55)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(15)
- PGD2 Receptor(2)
- Prostaglandin Receptor(168)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(4)
- S1P receptor(9)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(34)
- Sigma Receptor(54)
- Vasopressin Receptor(33)
- 17,20-lyase(7)
- Ras(118)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(5)
- TSH Receptor(10)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(22)
- GPR84(5)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(4)
- CRFR(21)
- RGS Protein(7)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(23)
- GPR139(3)
- mAChR(179)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(72)
- cGMP(18)
- GRK(1)
Products for GPCR/G protein
- Cat.No. Product Name Information
-
GC10600
1,3-Dipropyl-8-phenylxanthine
A1 adenosine antagonist
- GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors
-
GC16031
1-(3-Chlorophenyl)piperazine (hydrochloride)
5-HT2C/2B receptor agonist/partial agonist
- GC17913 1-Deazaadenosine adenosine deaminase inhibitor
- GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective
-
GC42011
1-Oleoyl Lysophosphatidic Acid
A potent LPA receptor agonist
-
GC15140
1-Oleoyl lysophosphatidic acid sodium salt
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, as a potent bioactive phospholipid, is a LPA receptor activator.
- GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist
- GC10821 11-keto-β-Boswellic Acid 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.
- GC41883 12(S)-HHTrE 12(S)-HHTrE (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism.
- GC16693 13Z,16Z-Docosadienoic Acid FFAR4(GPR120) agonist
- GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
-
GC11133
16,16-Dimethyl Prostaglandin E2
derivative of prostaglandin E2
- GC32770 1A-116 1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo.
- GC17757 1H-1-ethyl Candesartan Cilexetil selective angiotensin II type 1 receptor (AT1) antagonist
- GC11112 2'-MeCCPA A1 adenosine receptor agonist
- GC66678 2-(3-Trifluoromethylphenyl)glycine hydrochloride 2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research.
- GC30561 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.
-
GC16403
2-Arachidonoyl Glycerol
An endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2
- GC10116 2-chloro-3-Deazaadenosine adenosine receptors agonist
- GC11665 2-Chloro-N6-cyclopentyladenosine adenosine A1 receptor agonist, potent and selective
- GC15111 2-Chloroadenosine adenosine receptor agonist
- GC17503 2-Cl-IB-MECA 2-Cl-IB-MECA (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). 2-Cl-IB-MECA displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
- GC14445 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine nonpeptidic angiotensin II receptor antagonist
- GC17218 2-fluoro Palmitic Acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase
- GC14690 2-Iodomelatonin melatonin agonist
- GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist.
- GC11176 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist.
- GC64027 2-Methylthio-AMP 2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist.
- GC62783 2-Methylthio-AMP diTEA 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist.
- GC60016 2-Methylthioadenosine diphosphate trisodium An agonist of P2Y receptors
- GC16412 2-MPMDQ α1-adrenoceptor antagonist,potent and selective
-
GC40406
2-Oleoyl Glycerol
2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol.
- GC16196 2-Palmitoylglycerol Endogenous fatty acid glycerol ester
- GC11288 2-Phenylmelatonin 2-Phenylmelatonin is a high affinity melatonin (MT) membrane receptor agonist.
- GC13695 2-PMDQ α1-adrenoceptor antagonist
- GC14753 2-ThioUTP tetrasodium salt P2Y2 agonist
- GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor
- GC60467 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone?
- GC63737 21-Desacetyldeflazacort-D5
- GC11427 26RFa natural ligand of the orphan receptor GPR103
- GC15232 3,5-DHBA hydroxycarboxylic acid receptor 1 (HCA1) agonist
- GC15569 3-AQC 5-HT3 antagonist
- GC16689 3-chloro-5-hydroxy BA 3-chloro-5-hydroxy BA is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81.
- GC68328 3-Hydroxy agomelatine-d3
- GN10169 3-Hydroxy-4-methoxycinnamic acid
- GC10073 3-MPPI ligand for adrenergic α1 receptor
- GC17149 4-CMTB FFA2 agonist
- GC39678 4-Deoxypyridoxine 5'-phosphate A vitamin B6 analog and an inhibitor of S1P lyase
- GC68327 4-Hydroxyatomoxetine-d3
- GC64116 4-Hydroxypropranolol-d7
- GC17723 4-IBP σ1 agonist
- GC42460 4-Nitrophenyl Phenylphosphonate 4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterases.
-
GC16186
4-P-PDOT
Melatonin receptor antagonist
- GC13357 4-PPBP maleate σ ligand and NR1a/2B NMDA receptors antagonist
- GC17100 4-Quinolone-3-Carboxamide CB2 Ligand ligand of the CB2 receptor
- GC15850 4-Quinolone-3-Carboxamide Furan CB2 Agonist 4-Quinolone-3-Carboxamide Furan CB2 Agonist is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM.
- GC16040 4F 4PP oxalate 5-HT2A antagonist
- GC11002 5'-(N-Cyclopropyl)carboxamidoadenosine adenosine A2 receptor agonist
- GC14814 5-Carboxamidotryptamine maleate 5-HT1 agonist
- GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.
- GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.
- GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727.
- GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM.
- GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor.
- GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist.
- GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
- GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8.
- GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
- GC14801 5-Iodotubercidin An adenosine kinase inhibitor
- GC64182 5-Methoxytryptamine hydrochloride
- GC35168 5-O-Demethylnobiletin 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2.
-
GC13588
5-OMe-UDP trisodium salt
Potent P2Y6 agonist
- GC17719 5-trans U-46619 Prostaglandin E synthase inhibitor
- GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM.
- GC42587 6α-Methylprednisolone 21-hemisuccinate 6α-Methylprednisolone 21-hemisuccinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.
-
GC12014
6-Chloromelatonin
melatonin agonist
- GC11350 6-OAU synthetic agonist for GPR84
- GC15478 6H05 K-Ras inhibitor
- GC60533 6H05 (TFA) An allosteric inhibitor of oncogenic K-Ras(G12C)
- GC34427 6H05 trifluoroacetate (K-Ras inhibitor)
- GC35185 7,4'-Dihydroxyflavone 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production.
- GC14433 7α,25-dihydroxy Cholesterol A GPR183 agonist
- GC11199 8-(3-Chlorostyryl)caffeine 8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist.
-
GC13274
8-Aminoadenine
Adenine receptor agonist
- GC50588 8-Azaadenosine ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
- GC50354 8-Cyclopentyl-1,3-dimethylxanthine High affinity adenosine A1 receptor antagonist
- GC16020 8-M-PDOT Melatonin receptor agonist
- GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
- GC50247 A 127722 Highly potent, selective ETA antagonist; orally bioavailable
- GC14527 A 61603 hydrobromide A 61603 hydrobromide is a selective α1A-adrenergic receptor agonist.
- GC11004 A 779 angiotensin-(1-7)/ Mas receptor antagonist
- GC13027 A 80426 mesylate α2-adrenoceptor antagonist and 5-HT uptake inhibitor
- GC60544 A-192621 A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM.
- GC16913 A-71623 CCK1 agonist
- GC18199 A-836339 A-836339 is a synthetic cannabinoid (CB) which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 receptor (Ki = 270 nM).
-
GC42664
A-971432
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 μM, respectively).
- GC30918 A2A receptor antagonist 1 A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively.
- GC30987 A2AR-agonist-1 An agonist of adenosine A2A receptor and inhibitor of ENT1
- GC38104 A2aR/A2bR antagonist-1 A2aR/A2bR antagonist-1 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist.